Metabolism of Synthetic Steroids by the Human Placenta

Placenta

Volumn 28, Issue 5-6, 2007, Pages 588-589

  Bahr V ^a   Oelkers, W ^b   Pfeiffer, A F H ^a,c   Diederich, S ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Endokrinologikum Berlin   (Germany)

^c GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; BETAMETHASONE; DESOXIMETASONE; DEXAMETHASONE; DIFLUCORTOLONE; FLUDROCORTISONE; FLUMETASONE; GLUCOCORTICOID; ISOFLUPREDONE; STEROID;

ASTHMA; BIRTH WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG USE; ENZYME LOCALIZATION; EXPRESSION VECTOR; GENETIC TRANSFECTION; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; KIDNEY PARENCHYMA; LETTER; MICROSOME; PATIENT MONITORING; PLACENTA; PLACENTA WEIGHT; PLACENTAL TRANSFER; PREGNANCY; PRIORITY JOURNAL; STEROID METABOLISM; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION;

FEMALE; HUMANS; HYDROCORTISONE; PLACENTA; PREGNANCY; STEROIDS;

EID: 34247216708     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2006.05.004     Document Type: Letter

References (6)

1. Murphy V.E., Fittock R.J., Zarzycki P.K., Delahunty M.M., Smith R., and Clifton V.L. Metabolism of synthetic steroids by the human placenta. Placenta (2006)
2. Diederich S., Hanke B., Burkhardt P., et al. Metabolism of synthetic corticosteroids by 11β-hydroxysteroid-dehydrogenases in man. Steroids 63 (1998) 271-277
3. Diederich S., Hanke B., Oelkers W., and Bähr V. Metabolism of dexamethasone in the human kidney: nicotinamide adenine dinucleotide-dependent 11β-reduction. J Clin Endocrinol Metab 82 (1997) 1598-1602
4. Diederich S., Eigendorff E., Burkhardt P., et al. 11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids. J Clin Endocrinol Metab 87 12 (2002) 5695-5701
5. Blanford A.T., and Murphy B.E. In vitro metabolism of prednisolone, dexamethasone, betamethasone, and cortisol by the human placenta. Am J Obstet Gynecol 127 3 (1977) 264-267
6. Anderson A.B., Gennser G., Jeremy J.Y., Ohrlander S., Sayers L., and Turnbull A.C. Placental transfer and metabolism of betamethasone in human pregnancy. Obstet Gynecol 49 4 (1977) 471-474