Decreased induction of IL-1β in fibroblast-like synoviocytes: A possible regulatory mechanism maintaining joint homeostasis

Molecular Immunology

Volumn 44, Issue 12, 2007, Pages 3147-3154

  Nadiv, Orna ^a   Beer, Yiftah ^a   Goldberg, Michael ^a   Agar, Gabriel ^a   Loos, Michael ^b   Katz, Yitzhak ^a,c  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Dermal fibroblasts; Gene expression; IL 1 ; IL 6; IL 8; OA; RA; Synoviocytes; TNF

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; METHIONINE; METHIONINE S 35; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTHROPATHY; ARTICLE; CELL GROWTH; CELL LABELING; CONTROLLED STUDY; FEMALE; FIBROBLAST; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MALE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SECRETION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RHEUMATOID ARTHRITIS; SKIN CULTURE; SYNOVIOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; CELLS, CULTURED; DOWN-REGULATION; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; JOINTS; MALE; MIDDLE AGED; SYNOVIAL MEMBRANE;

EID: 34247214963     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2007.02.001     Document Type: Article

References (38)

1. Ameye L.G., and Young M.F. Animal models of osteoarthritis: lessons learned while seeking the 'Holy Grail'. Curr. Opin. Rheumatol. 18 September (5) (2006) 537-547
2. Arend W.P., and Dayer J.-M. Inhibition of the production and effects of interleukin-1 and TNFa in rheumatoid arthritis. Arthritis Rheum. 38 (1995) 151-160
3. Auron P.E., Webb A.C., Rosenwasser L.J., et al. Nucleoide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. U.S.A. 81 (1984) 7907-7911
4. Badolato R., and Oppenheim J.J. Role of cytokines, acute-phase proteins, and chemokines in the pregression of rheumatoid arthritis. Semin. Arthritis Rheum. 26 (1996) 526-538
5. Benito M.J., Veale D.J., FitzGerald O., van den Berg W.B., and Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann. Rheum. Dis. 64 September (9) (2005) 1263-1267 (Epub February 24)
6. Bioque G., Crusius J.B., Koutroubakis I., et al. Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease. Clin. Exp. Immunol. 102 (1995) 379-383
7. Cagnard N., Letourneur F., Essabbani A., Devauchelle V., Mistou S., Rapinat A., Decraene C., Fournier C., and Chiocchia G. Interleukin-32, CCL2, PF4F1 and GFD10 are the only cytokine/chemokine genes differentially expressed by in vitro cultured rheumatoid and osteoarthritis fibroblast-like synoviocytes. Eur. Cytokine Netw. 16 December (4) (2005) 289-292
8. Clements K.M., Price J.S., Chambers M.G., Visco D.M., Poole A.R., and Mason R.M. Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum. 48 December (12) (2003) 3452-3463
9. de Hooge A.S., van de Loo F.A., Bennink M.B., Arntz O.J., de Hooge P., and van den Berg W.B. Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. Osteoarthritis Cartilage 13 January (1) (2005) 66-73
10. Firestein G.S., Alvaro-Gracia J.M., and Maki R. Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J. Immunol. 144 (1990) 3347-3353
11. Fischer D.-C., Siebertz B., van de Leur E., et al. Induction of a1-antitrypsin synthesis in human articular chondrocytes by interleukin-6-type cytokines. Evidence for a local acute-phase response in the joint. Arthritis Rheum. 42 (1999) 1936-1945
12. Glasson S.S., Askew R., Sheppard B., Carito B., Blanchet T., Ma H.L., Flannery C.R., Peluso D., Kanki K., Yang Z., Majumdar M.K., and Morris E.A. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434 March (7033) (2005) 644-648
13. Goldring M.B. The role of the chondrocyte in osteoarthritis. Arthritis Rheum. 43 (2000) 1916-1926
14. Harris E.D. Rheumatoid arthritis: pathophysiology and implications for therapy. N. Engl. J. Med. 322 (1990) 1277-1289
15. Hedbom E., and Hauselmann H.J. Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation. Cell. Mol. Life Sci. 59 (2002) 45-53
16. Ishii H., Tanaka H., Katoh K., Nakamura H., Magashima M., and Yoshino S. Characterization of infiltrating T cells and Th1/Th2-type cytokines in the synovium of patients with osteoarthritis. Osteoarthritis Cartilage 10 (2002) 277-281
17. Joosten L.A.B., Helsen M.M.A., Saxne T., van de Loo F.A.J., Heinegard D., and van den Berg W.B. IL-1ab blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF a blockade only ameliorated joint inflammation. J. Immunol. 163 (1999) 5049-5055
18. Joosten L.A., Netea M.G., Kim S.H., Yoon D.Y., Oppers-Walgreen B., Radstake T.R., Barrera P., van de Loo F.A., Dinarello C.A., and van den Berg W.B. IL-32, a proinflammatory cytokine in rheumatoid arthritis. Proc. Natl. Acad. Sci. U.S.A. 103 February (9) (2006) 3298-3303
19. Jouvenne P., Chaudhary A., Buchs N., Giovine F.S., Duff G.W., and Miossec P. Possible genetic association between interleukin-1 alpha gene polymorphism and the severity of chronic polyarthritis. Eur. Cytokine Netw. 10 (1999) 33-36
20. Katz Y., Nadiv O., and Beer Y. IL-17 enhances TNFα -induced synthesis of interleukins 1, 6 and 8 in skin and synovial fibroblasts. A possible role as a "fine-tuning cytokine" in inflammation processes. Arthritis Rheum. 44 (2001) 2176-2184
21. Katz Y., and Strunk R.C. Synovial fibroblast-like cells synthesize seven proteins of the complement system. Arthritis Rheum. 31 (1988) 1365-1370
22. Katz Y., and Strunk R.C. IL-1 and TNF: similarities and differences in stimulation of expression of alternative pathway of complement and IFN-b2/IL-6 genes in human fibroblasts. J. Immunol. 142 (1989) 3862-3867
23. Kim S.H., Han S.Y., Azam T., Yoon D.Y., and Dinarello CA. Interleukin-32: a cytokine and inducer of TNF alpha. Immunity 22 January (1) (2005) 131-142
24. Kuiper S., Joosten L.A., Bendele A.M., et al. Different roles of TNFα and IL-1 in murine streptococcal wall arthritis. Cytokine 10 (1998) 690-702
25. Moos V., Rudwaleit M., Herzog V., Hohlig K., Sieper J., and Muller B. Association of genotypes affecting the expression of IL-1β or IL-1 receptor antagonist with osteoarthritis. Arthritis Rheum. 43 (2000) 2417-2422
26. Moos V., Sieper J., Herzog V., and Muller B. Regulation of expression of cytokines and growth factors in osteoarthritic cartilage explants. Clin. Rheumatol. 20 (2001) 353-358
27. Morko J., Kiviranta R., Joronen K., Saamanen A.M., Vuorio E., and Salminen-Mankonen H. Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K. Arthritis Rheum. 52 December (12) (2005) 3713-3717
28. Paleolog E.M. Angiogenesis: a critical process in the pathogenesis of RA- a role for VEGF?. Br. J. Rheumatol. 35 (1996) 917-920
29. Saito I., Koshino T., Nakashima K., Uesugi M., and Saito T. Increased cellular infiltrate in inflammatory synovia of osteoarthritic knees. Osteoarthritis Cartilage 10 (2002) 156-162
30. Shingu M., Isayama T., Yasutake C., et al. Role of oxygen radicals and IL-6 in IL-1-dependent cartilage matrix degradation. Inflammation 18 (1994) 613-623
31. Shinmei M., Masuad K., Kikuchi T., and Shimomura Y. Interleukin 1, tumour necrosis factor, and interleukin 6 as mediators of cartilage destruction. Semin. Arthritis Rheum. 18 suppl. 1 (1989) 27-32
32. Silacci P., Dayer J.M., Desgeorges A., Peter R., Manueddu C., and Guerne P.A. IL-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity. J. Biol. Chem. 273 (1998) 13625-13629
33. Smith M.D., Triantafillou S., Parker A., Youssef P.P., and Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J. Rheumatol. 24 (1997) 365-371
34. Taga T., and Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15 (1997) 797-819
35. Ulfgren A.-K., Grondal L., Lindblad S., et al. Interindividual and intra-articular variation of proinflammatory cytokines in patients with rheumatoid arthritis: potential implications for treatment. Ann. Rheum. Dis. 59 (2000) 439-447
36. van de Loo F.A., Kuiper S., van Enckevort F.H., Arntz O.J., and van den Berg W.B. IL-6 reduces cartilage destruction during experimental arthritis: a study in IL-6-deficient mice. Am. J. Pathol. 151 (1997) 177-191
37. Zhang Y.W., Su Y., Lanning N., Swiatek P.J., Bronson R.T., Sigler R., Martin R.W., and Vande Woude G.F. Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Proc. Natl. Acad. Sci. U.S.A. 102 August (33) (2005) 11740-11745 (Epub 2005 August 8)
38. Zvaifler N.J., Boyle D., and Firestein G.S. Early synovitis-synoviocytes and mononuclear cells. Semin. Arthritis Rheum. 23 (1994) 11-16