Novel benzodiazepine photoaffinity probe stereoselectively labels a site deep within the membrane-spanning domain of the cholecystokinin receptor

Journal of Medicinal Chemistry

Volumn 49, Issue 3, 2006, Pages 850-863

  Hadac, Elizabeth M ^a   Dawson, Eric S ^b   Darrow, James W ^d   Sugg, Elizabeth E ^c   Lybrand, Terry P ^b   Miller, Laurence J ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GLAXOSMITHKLINE   (United States)

^d CGI Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 [3 (4 BENZOYLPHENYL)UREIDO] 2,4 DIOXO 5 PHENYL 2,3,4,5 TETRAHYDROBENZO[B][1,4]DIAZEPIN 1 YL] N (4 METHOXYLPHENYL) N METHYLACETAMIDE; 2 [3 [3 (4 BENZOYLPHENYL)UREIDO] 2,4 DIOXO 5 PHENYL 2,3,4,5 TETRAHYDROBENZO[B][1,4]DIAZEPIN 1 YL] N ISOPROPYL N (4 METHOXYPHENYL)ACETAMIDE; BENZODIAZEPINE DERIVATIVE; BENZOPHENONE DERIVATIVE; CHOLECYSTOKININ RECEPTOR; DEVAZEPIDE; LEUCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; COVALENT BOND; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENANTIOMER; LIGAND BINDING; MEMBRANE SPANNING DOMAIN; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PHOTOAFFINITY LABELING; PROTEIN DOMAIN; PROTEIN INTERACTION; RACEMIC MIXTURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

ANIMALS; BENZODIAZEPINES; BENZOPHENONES; BINDING SITES; CELL MEMBRANE; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; DEVAZEPIDE; LIGANDS; MODELS, MOLECULAR; PANCREAS; PHOTOAFFINITY LABELS; PROTEIN STRUCTURE, TERTIARY; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CHOLECYSTOKININ A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32344436490     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049072h     Document Type: Article

References (44)

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