FLIP inhibits endothelial cell apoptosis during hyperoxia by suppressing Bax

Free Radical Biology and Medicine

Volumn 42, Issue 10, 2007, Pages 1599-1609

  Wang, Xue ^a   Wang, Yong ^a   Kim, Hong Pyo ^a   Choi, Augustine M K ^a   Ryter, Stefan W ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Bax; FLIP; Hyperoxia; Protein kinase C

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; FLICE INHIBITORY PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BID; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C ETA; PROTEIN KINASE C ZETA; PROTEIN P47; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL PROTECTION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STABILITY; GOLGI COMPLEX; HYPEROXIA; INTRACELLULAR TRANSPORT; LUNG ENDOTHELIUM; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; HYPEROXIA; LUNG; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA;

EID: 34247207165     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2007.02.020     Document Type: Article

References (51)

1. Horowitz S., and Davis J.M. Lung injury when development is interrupted by premature birth. In: McDonald J.A. (Ed). Lung Growth and Development (1997), Decker, New York 577-610
2. Kazzaz J.A., Xu J., Palaia T.A., Mantell L., Fein A.M., and Horowitz S. Cellular oxygen toxicity. J. Biol. Chem. 271 (1996) 15182-15186
3. Petrache I., Choi M.E., Otterbein L.E., Chin B.Y., Mantell L.L., Horowitz S., and Choi A.M. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am. J. Physiol. 277 (1999) L589-L595
4. Wang X., Ryter S.W., Dai C., Tang Z.L., Watkins S.C., Yin X.M., Song R., and Choi A.M. Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway. J. Biol. Chem. 278 (2003) 29184-29191
5. Buccellato L.J., Tso M., Akinci O.I., Chandel N.S., and Budinger G.R. Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells. J. Biol. Chem. 279 (2004) 6753-6760
6. Zhang X., Shan P., Sasidhar M., Chupp G.L., Flavell R.A., Choi A.M., and Lee P.J. Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediate hyperoxia-induced cell death in lung epithelium. Am. J. Respir. Cell Mol. Biol. 28 (2003) 305-315
7. Tsan M.F. Superoxide dismutase and pulmonary oxygen toxicity. Proc. Soc. Exp. Biol. Med. 214 (1999) 107-113
8. Li J., Gao X., Qian M., and Eaton J.W. Mitochondrial metabolism underlies hyperoxic cell damage. Free Radic. Biol. Med. 36 (2004) 1460-1470
9. Parinandi N.L., Kleinberg M.A., Usatyuk P.V., Cummings R.J., Pennathur A., Cardounel A.J., Zweier J.L., Garcia J.G., and Natarajan V. Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 284 (2003) L26-L38
10. Lambeth J.D. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 4 (2004) 181-189
11. Li J.M., and Shah A.M. Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells. J. Biol. Chem. 277 (2002) 19952-19960
12. Chowdhury A.K., Watkins T., Parinandi N.L., Saatian B., Kleinberg M.E., Usatyuk P.V., and Natarajan V. Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells. J. Biol. Chem. 280 (2005) 20700-20711
13. Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81 (2001) 807-869
14. Nebreda A.R., and Porras A. p38 MAP kinases: beyond the stress response. Trends Biochem. Sci. 25 (2000) 257-260
15. Martinou J.C., and Green D.R. Breaking the mitochondrial barrier. Nat. Rev. Mol. Cell Biol. 2 (2001) 63-67
16. Antonsson B., Montessuit S., Lauper S., Eskes R., and Martinou J.C. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochem. J. 345 (2000) 271-278
17. Huang D.C., and Strasser A. BH3-Only proteins-essential initiators of apoptotic cell death. Cell 103 (2000) 839-842
18. Walsh C.M., Luhrs K.A., and Arechiga A.F. The "fuzzy logic" of the death-inducing signaling complex in lymphocytes. J. Clin. Immunol. 23 (2003) 333-353
19. Rasper D.M., Vaillancourt J.P., Hadano S., Houtzager V.M., Seiden I., Keen S.L., Tawa P., Xanthoudakis S., Nasir J., Martindale D., Koop B.F., Peterson E.P., Thornberry N.A., Huang J., MacPherson D.P., Black S.C., Hornung F., Lenardo M.J., Hayden M.R., Roy S., and Nicholson D.W. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. Cell Death Differ. 5 (1998) 271-288
20. Micheau O. Cellular FLICE-inhibitory protein: an attractive therapeutic target?. Expert Opin. Ther. Targets 7 (2003) 559-573
21. Barnhart B.C., Lee J.C., Alappat E.C., and Peter M.E. The death effector domain protein family. Oncogene 22 (2003) 8634-8644
22. Wang X., Zhou Y., Kim H.P., Song R., Zarnegar R., Ryter S.W., and Choi A.M. Hepatocyte growth factor protects against hypoxia/reoxygenation-induced apoptosis in endothelial cells. J. Biol. Chem. 279 (2004) 5237-5243
23. Wang X., Zhang J., Kim H.P., Wang Y., Choi A.M., and Ryter S.W. Bcl-XL disrupts death-inducing signal complex formation in plasma membrane induced by hypoxia/reoxygenation. FASEB J. 18 (2004) 1826-1833
24. Wang X., Wang Y., Zhang J., Kim H.P., Ryter S.W., and Choi A.M. FLIP protects against hypoxia/reoxygenation-induced endothelial cell apoptosis by inhibiting Bax activation. Mol. Cell. Biol. 25 (2005) 4742-4751
25. Gomez-Angelats M., and Cidlowski J.A. Protein kinase C regulates FADD recruitment and death-inducing signaling complex formation in Fas/CD95-induced apoptosis. J. Biol. Chem. 276 (2001) 44944-44952
26. Trauzold A., Schmiedel S., Sipos B., Wermann H., Westphal S., Roder C., Klapper W., Arlt A., Lehnert L., Ungefroren H., Johannes F.J., and Kalthoff H. PKCmu prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells. Oncogene 22 (2003) 8939-8947
27. Villalba M., Bushway P., and Altman A. Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD. J. Immunol. 166 (2001) 5955-5963
28. Yethon J.A., Epand R.F., Leber B., Epand R.M., and Andrews D.W. Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis. J. Biol. Chem. 278 (2003) 48935-48941
29. Crapo J.D. Morphologic changes in pulmonary oxygen toxicity. Annu. Rev. Physiol. 48 (1986) 721-731
30. Matalon S., and Egan E.A. Interstitial fluid volumes and albumin spaces in pulmonary oxygen toxicity. J. Appl. Physiol. 57 (1984) 1767-1772
31. Wang X., Wang Y., Kim H.P., Nakahira K., Ryter S.W., and Choi A.M.K. Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation. J. Biol. Chem. 282 (2007) 1718-1726
32. Mantell L.L., Horowitz S., Davis J.M., and Kazzaz J.A. Ann. N. Y. Acad. Sci. 887 (1999) 171-180
33. Barazzone-Argiroffo C., Donati Y.R., Boccard J., Rochat A.F., Vesin C., Kan C.D., and Piguet P.F. CD40-CD40 ligand disruption does not prevent hyperoxia-induced injury. Am. J. Pathol. 160 (2002) 67-71
34. Pryhuber G.S., O'Brien D.P., Baggs R., Phipps R., Huyck H., Sanz I., and Nahm M.H. Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 278 (2000) L1082-L1090
35. Guthmann F., Wissel H., Schachtrup C., Tolle A., Rudiger M., Spener F., and Rustow B. Inhibition of TNFalpha in vivo prevents hyperoxia-mediated activation of caspase 3 in type II cells. Respir. Res. 6 (2005) 10
36. Yoshimura S.I., Nakamura N., Barr F.A., Misumi Y., Ikehara Y., Ohno H., Sakaguchi M., and Mihara K. Direct targeting of cis-Golgi matrix proteins to the Golgi apparatus. J. Cell Sci. 114 (2001) 4105-4115
37. Shikama Y., Shen L., Yonetani M., Miyauchi J., Miyashita T., and Yamada M. Death effector domain-only polypeptides of caspase -8 and - 10 specifically inhibit death receptor-induced cell death. Biochem. Biophys. Res. Commun. 291 (2002) 484-493
38. Walker A., Ward C., Sheldrake T.A., Dransfield I., Rossi A.G., Pryde J.G., and Haslett C. Golgi fragmentation during Fas-mediated apoptosis is associated with the rapid loss of GM130. Biochem. Biophys. Res. Commun. 316 (2004) 6-11
39. Ivanov V.N., Lopez Bergami P., Maulit G., Sato T.A., Sassoon D., and Ronai Z. FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface. Mol. Cell. Biol. 23 (2003) 3623-3635
40. Krueger A., Schmitz I., Baumann S., Krammer P.H., and Kirchhoff S. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J. Biol. Chem. 276 (2001) 20633-20640
41. Barazzone C., and White C.W. Mechanisms of cell injury and death in hyperoxia: role of cytokines and Bcl-2 family proteins. Am. J. Respir. Cell Mol. Biol. 22 (2000) 517-519
42. Pagano A., Donati Y., Metrailler I., and Barazzone Argiroffo C. Mitochondrial cytochrome c release is a key event in hyperoxia-induced lung injury: protection by cyclosporin A. Am. J. Physiol. Lung Cell Mol. Physiol. 286 (2004) L275-L283
43. Goping I.S., Gross A., Lavoie J.N., Nguyen M., Jemmerson R., Roth K., Korsmeyer S.J., and Shore G.C. Regulated targeting of BAX to mitochondria. J. Cell Biol. 143 (1998) 207-215
44. Sundararajan R., and White E. E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis. J. Virol. 75 (2001) 7506-7516
45. Nechushtan A., Smith C.L., Lamensdorf I., Yoon S.H., and Youle R.J. Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. J. Cell Biol. 153 (2001) 1265-1276
46. Wolter K.G., Hsu Y.T., Smith C.L., Nechushtan A., Xi X.G., and Youle R.J. Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol. 139 (1997) 1281-1291
47. Truong S.V., Monick M.M., Yarovinsky T.O., Powers L.S., Nyunoya T., and Hunninghake G.W. Extracellular signal-regulated kinase activation delays hyperoxia-induced epithelial cell death in conditions of Akt downregulation. Am. J. Respir. Cell Mol. Biol. 31 (2004) 611-618
48. Gardai S.J., Hildeman D.A., Frankel S.K., Whitlock B.B., Frasch S.C., Borregaard N., Marrack P., Bratton D.L., and Henson P.M. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J. Biol. Chem. 279 (2004) 21085-21095
49. Neri L.M., Borgatti P., Capitani S., and Martelli A.M. Protein kinase C isoforms and lipid second messengers: a critical nuclear partnership?. Histol. Histopathol. 17 (2002) 1311-1316
50. McJilton M.A., Van Sikes C., Wescott G.G., Wu D., Foreman T.L., Gregory C.W., Weidner D.A., Harris Ford O., Morgan Lasater A., Mohler J.L., and Terrian D.M. Protein kinase Cepsilon interacts with Bax and promotes survival of human prostate cancer cells. Oncogene 22 (2003) 7958-7968
51. Das K.C., Pahl P.M., Guo X.L., and White C.W. Induction of peroxiredoxin gene expression by oxygen in lungs of newborn primates. Am. J. Respir. Cell Mol. Biol. 25 (2001) 226-232