Genomic analysis of nucleoside transporters in Diptera and functional characterization of DmENT2, a Drosophila equilibrative nucleoside transporter

Physiological Genomics

Volumn 28, Issue 3, 2007, Pages 337-347

  Machado, Jerry ^a   Abdulla, Parween ^a   Hanna, W J Brad ^b   Hilliker, Arthur J ^a   Coe, Imogen R ^a  

^a YORK UNIVERSITY   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

Anopheles; Concentrative nucleoside transporters; Evolution

Indexed keywords

EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2; NUCLEOSIDE TRANSPORTER; CARRIER PROTEIN; DROSOPHILA PROTEIN; ENT2 PROTEIN, DROSOPHILA; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANOPHELES GAMBIAE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DROSOPHILA; DROSOPHILA MELANOGASTER; FLY; GENE EXPRESSION; GENE SEQUENCE; GENOMICS; IN SITU HYBRIDIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; ANIMAL; COMPARATIVE STUDY; GENETICS; METABOLISM; MOLECULAR GENETICS; OOCYTE; PRENATAL DEVELOPMENT; SEQUENCE ALIGNMENT; XENOPUS;

ANOPHELES GAMBIAE; DIPTERA; DROSOPHILA MELANOGASTER; EUKARYOTA; INVERTEBRATA; VERTEBRATA;

AMINO ACID SEQUENCE; ANIMALS; ANOPHELES GAMBIAE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EQUILIBRATIVE NUCLEOSIDE TRANSPORT PROTEINS; IN SITU HYBRIDIZATION; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; OOCYTES; PHYLOGENY; SEQUENCE ALIGNMENT; XENOPUS;

EID: 34247198906     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00087.2006     Document Type: Article

References (32)

1. Acimovic Y, Coe IR. Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes. Mol Biol Evol 19: 2199-2210, 2002.
2. Ackley MA, Governo RJM, Cass CE, Young JD, Baldwin SA, King AE. Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1. J Physiol 548: 507-17, 2003.
3. Ashurst JL, Collins JE. Gene annotation: prediction and testing. Annu Rev Genomics Hum Genet 4: 69-88, 2003.
4. Baldwin SA, Beal PR, Yao SYM, King AE, Cass CE, Young JD. The equilibrative nucleoside transporter family, SLC29. Pflügers Arch 447: 735-743, 2004.
5. Baldwin SA, Yao SY, Hyde RJ, Ng AM, Foppolo S, Barnes K, Ritzel MW, Cass CE, Young JD. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem 280: 15880-15887, 2005.
6. Baldwin SA, Mackey JR, Cass CE, Young JD. Nucleoside transporters: Molecular biology and implications for therapeutic development. Mol Med Today 5: 216-224, 1999.
7. Barnes K, Dobrzynski H, Foppolo S, Beal PR, Ismat F, Scullion ER, Sun L, Tellez J, Ritzel MWL, Claycomb WC, Cass CE, Young JD, Billeter-Clark R, Boyett MR, Baldwin SA. Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Circ Res 99: 453-454, 2006.
8. Boleti H, Coe IR, Baldwin SA, Young JD, Cass CE. Molecular identification of the equilibrative NBMPR-sensitive (es) nucleoside transporter and demonstration of an equilibrative NBMPR-insensitive (ei) transport activity in human erythroleukemia (K562) cells. Neuropharmacology 36: 1167-1179, 1997.
9. Bolshakov VN, Topalis P, Blass C, Kokoza E, Torre AD, Kafatos FC, Louis C. A comparative genomic analysis of two distant Diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae. Genome Res 12: 57-66, 2002.
10. Cabrita MA, Baldwin SA, Young JD, Cass CE. Molecular biology and regulation of nucleoside and nucleobase transporter proteins in eukaryotes and prokaryotes. Biochem Cell Biol 80: 623-638, 2002.
11. Cass CE, Young JD, Baldwin SA. Recent advances in the molecular biology of nucleoside transporters of mammalian cells. Biochem Cell Biol 76: 761-770, 1998.
12. Graham KA, Leithoff J, Coe IR, Mowles D, Mackey JR, Young JD, Cass CE. Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1. Nucleosides Nucleotides 19: 415-434, 2000.
13. Gray JH, Owen RP, Giacomini KM. The concentrative nucleoside transporter family, SLC28. Pflügers Arch 447: 728-734, 2004.
14. Griffiths M, Beaumont N, Yao SYM, Sundaram M, Boumah CE, Davies A, Kwong FYP, Coe I, Cass CE, Young JD, Baldwin SA. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat Med 3: 89-93, 1997.
15. Jimenez A, Pubill D, Pallas M, Camins A, Llado S, Camarasa J, Escubedo E. Further characterization of an adenosine transport system in the mitochondrial fraction of rat testis. Eur J Pharmacol 398: 31-39, 2000.
16. Khatri P, Done B, Rao A, Done A, Draghici S. A semantic analysis of the annotations of the human genome. Bioinformatics 21: 3416-3421, 2005.
17. Kiss A, Farah K, Kim J, Garriock RJ, Drysdale TA, Hammond JR. Molecular cloning and functional characterization of inhibitor-sensitive (mENT1) and inhibitor-resistant (mENT2) equilibrative nucleoside transporters from mouse brain. Biochem J 352: 363-372, 2000.
18. Kumar S, Tamura K, Nei M. MEGA3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform 5: 150-163, 2004.
19. Land KM. The Mosquito genome: perspectives and possibilities. Trends Parasitol 19: 103-105, 2003.
20. Landfear SM, Ullman B, Carter NS, Sanchez MA. Nucleoside and nucleobase transporters in parasitic protozoa. Eukaryot Cell 3: 245-254, 2004.
21. Li G, Liu K, Baldwin SA, Wang D. Equilibrative nucleoside transporters of Arabidopsis thaliana: cDNA cloning, expression pattern and analysis of transport activities. J Biol Chem 278: 35732-35742, 2003.
22. Martin RE, Henry RI, Abbey JL, Clements JD, Kirk K. The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum. Genome Biol 6: R26, 2005.
23. Mohlmann T, Mezher Z, Schwerdtfeger G, Neuhaus HE. Characterization of a concentrative type of adenosine transporter from Arabidopsis thaliana (ENT1, At). FEBS Lett 509: 370-374, 2001.
24. Parker MD, Hyde RJ, Yao SY, McRobert L, Cass CE, Young JD, McConkey GA, Baldwin SA. Identification of a nucleoside/nucleobase transporter from Plasmodium falciparum, a novel target for anti-malarial chemotherapy. Biochem J 349: 67-75, 2000.
25. Pisoni RL, Thoene JG. Detection and characterization of a nucleoside transport system in human fibroblast lysosomes. J Biol Chem 264: 4850-4856, 1989.
26. Reyes G, Coe IR. Genomics and proteomics of nucleoside transporters. Current Pharmacogenomics 3: 281-287, 2005.
27. Sankar N, Machado J, Abdulla P, Hilliker AJ, Coe IR. Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity. Nucleic Acids Res 30: 4339-4350, 2002.
28. Simin K, Scuderi A, Reamey J, Dunn D, Weiss R, Metherall JE, Letsou A. Profiling patterned transcripts in Drosophila embryos. Genome Res 12: 1040-1047, 2002.
29. Stein A, Vaseduvan G, Carter NS, Ullman B, Landfear SM, Kavanaugh M. Equilibrative nucleoside transporter family members from Leishmania donovani are electrogenic proton symporters. J Biol Chem 278: 35127-35134, 2003.
30. Visser F, Vickers MF, Ng AML, Baldwin SA, Young JD, Cass CE. Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole. J Biol Chem 277: 395-401, 2002.
31. Ward JL, Sherali A, Mo Z, Tse C. Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J Biol Chem 275: 8375-8381, 2000.
32. Zbdobnov EM, Mering CV, Letunic I, Torrents D, Suyama M, Copley RR, Christophides GK, Thomasova D, Holt RA, Subramanian GM, Mueller H, Dimopoulos G, Law JH, Wells MA, Birney E, Charlab R, Halpern AL, Kokoza E, Kraft CL, Lai Z, Lewis S, Louis C, Barillas-Mury C, Nusskern D, Rubin GM, Salzberg SL, Sutton GG, Pantelis T, Wides R, Wincker P, Yandell M, Collins FH, Ribeiro J, Gelbart WM, Kafatos FC, Bork P. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science 298: 149-159, 2002.