Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10

Liver Transplantation

Volumn 13, Issue 4, 2007, Pages 571-578

  Yang, Zhen Fan ^a   Ngai, Patricia ^a   Lau, Chi Keung ^a   Ho, David W ^a   Tam, Ka Ho ^a   Lam, Chi Tat ^a   Poon, Ronnie T ^a   Fan, Sheung Tat ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; TACROLIMUS; TRANSCRIPTION FACTOR FOXP3;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DARK AGOUTI RAT; DOWN REGULATION; DRUG MECHANISM; EX VIVO STUDY; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LEWIS RAT; LIVER TRANSPLANTATION; LOW DRUG DOSE; MACROPHAGE; MALE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SURVIVAL TIME; UPREGULATION;

ANIMALS; CELL CULTURE TECHNIQUES; DRUG ADMINISTRATION SCHEDULE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSION; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; RATS; RATS, INBRED LEW; RATS, INBRED STRAINS; RNA; TACROLIMUS; TIME FACTORS; TRANSPLANTATION, HOMOLOGOUS;

EID: 34247194227     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.21091     Document Type: Article

References (34)

1. Starzl TE, Lakkis FG. The unfinished legacy of liver transplantation: emphasis on immunology. Hepatology 2006; 43(2 Suppl 1):S151-S163.
2. Martinez OM, Rosen HR. Basic concepts in transplant immunology. Liver Transpl 2005;11:370-381.
3. Thomson AW, Mazariegos GV, Reyes J, Donnenberg VS, Donnenberg AD, Bentlejewski C, et al. Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients. Transplantation 2001;72:S13-S22.
4. Sanchez-Fueyo A, Strom TB. Immunological tolerance and liver transplantation. J Hepatol 2004;41:698-705.
5. Perry I, Neuberger J. Immunosuppression: towards a logical approach in liver transplantation. Clin Exp Immunol 2005;139:2-10.
6. Fung J, Kelly D, Kadry Z, Patel-Tom K, Eghtesad B. Immunosuppression in liver transplantation: beyond calcineurin inhibitors. Liver Transpl 2005;11:267-280.
7. Fairbanks KD, Eustace JA, Fine D, Thuluvath PJ. Renal function improves in liver transplant recipients when switched from a calcineurin inhibitor to sirolimus. Liver Transpl. 2003;9:1079-1085.
8. + regulatory T cells in mouse hepatic allograft tolerance. Liver Transpl 2006:12: 1112-1118.
9. Li W, Zheng XX, Kuhr CS, Perkins JD. CTLA4 engagement is required for induction of murine liver transplant spontaneous tolerance. Am J Transplant 2005;5:978-986.
10. Yang Z, Wu X, Tsui TY, Hou Y, Luk JM, Fan ST. Long-term liver allograft survival induced by combined treatment with rAAV-hCTLA4Ig gene transfer and low-dose FK506. Transplantation 2003;75:303-308.
11. Battaglia M, Gregori S, Bacchetta R, Roncarolo MG. Tr1 cells: from discovery to their clinical application. Semin Immunol 2006;18:120-127.
12. Zhou X, Schmidtke P, Zepp F, Meyer CU. Boosting interleukin-10 production: therapeutic effects and mechanisms. Curr Drug Targets Immune Endocr Metabol Disord 2005;5:465-475.
13. Le Moine O, Marchant A. Durand F, Ickx B, Pradier O, Belghiti J, et al. Systemic release of interleuldn-10 during orthotopic liver transplantation. Hepatology 1994;20:889-892.
14. Racanelli V, Rehermann B. The liver as an immunological organ. Hepatology 2006;43:S54-S62.
15. Yang ZF, Ho DW, Chu AC, Wang YQ, Fan ST. Linking inflammation to acute rejection in small-for-size liver allografts: the potential role of early macrophage activation. Am J Transplant 2004;4:196-209.
16. Everett ML, Collins BH, Parker W. Kupffer cells: another player in liver tolerance induction. Liver Transpl 2003;9:498-499.
17. Crispe IN. Hepatic T cells and liver tolerance. Nat Rev Immunol 2003;3:51-62.
18. Yamamoto S, Okuda T, Yamasaki K, Tanaka H, Kubo S, Takemura S, et al. FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation. Transplantation. 2004;78:1618-1625.
19. Guo L, Li XK, Enosawa S, Funeshima N, Suzuki S, Kimura H, et al. Significant enhancement by anti-ICOS antibody of suboptimal tacrolimus immunosuppression in rat liver transplantation. Liver Transpl 2004;10:743-747.
20. Kamada N, Calne RY. Orthotopic liver transplantation in the rat. Technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 1979;28:47-50.
21. Autieri MV, Carbone CM. Overexpression of allograft inflammatory factor-1 promotes proliferation of vascular smooth muscle cells by cell cycle deregulation. Arterioscler Thromb Vasc Biol 2001;21:1421-1426.
22. Yang ZF, Poon RT, Luo Y, Cheung CK, Ho DW, Lo CM, et al. Up-regulation of vascular endothelial growth factor (VEGF) in small-for-size liver grafts enhances macrophage activities through VEGF receptor 2-dependent pathway. J Immunol 2004;173:2507-2515.
23. Kita Y, Li XK, Ohba M, Funeshima N, Enosawa S, Tamura A, et al. Prolonged cardiac allograft survival in rats systemically injected adenoviral vectors containing CTLA4Iggene. Transplantation 1999;68:758-766.
24. Herrmann MM, Gaertner S, Stadelmann C, van den Brandt J, Boscke R, Budach W, et al. Tolerance induction by bone marrow transplantation in a multiple sclerosis model. Blood 2005;106:1875-1883.
25. Nagakawa Y, Nomoto S, Kato Y, Montgomery RA, Williams GM, Klein AS, et al. Over-expression of AIF-1 in liver alloqafts and peripheral blood correlates with acute rejection after transplantation in rats. Am J Transplant 2004;4:1949-1957.
26. Yang ZF, Ho DW, Ngai P, Lau CK, Zhao Y, Poon RT, et al. Anti-inflammatory properties of IL-10 rescue small-for-size liver grafts. Liver Transpl. 2007;13:558-565.
27. Pulitano C, Sitia G, Aldrighetti L, Finazzi R, Arru M, Catena M, et al. Reduced severity of liver ischemia/reperfusion injury following hepatic resection in humans is associated with enhanced intrahepatic expression of Th2 cytokines. Hepatol Res 2006;36:20-26.
28. Godet C, Goujon JM, Petit I, Lecron JC, Hauet T, Mauco G, et al. Endotoxin tolerance enhances interleukin-10 renal expression and decreases ischemia-reperfusion renal injury in rats. Shock 2006;25:384-388.
29. Donckier V, Loi P, Closset J, Nagy N, Quertinmont E, Le Moine O, et al. Preconditioning of donors with interleukin-10 reduces hepatic ischemia-reperfusion injury after liver transplantation in pigs. Transplantation 2003;75:902-904.
30. Yang ZF, Ho DW, Lau CK, Lam CT, Lum CT, Poon RT, et al. Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages. Int Immunol 2005;17:1391-1397.
31. + regulatory T cells in the maintenance of T cell homeostasis. J Exp Med 2004;200:1123-1134.
32. Xystrakis E, Dejean AS, Bernard I, Druet P, Liblau R, Gonzalez-Dunia D, et al. Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation. Blood 2004;104:3294-3301.
33. Slattery C, Campbell E, McMorrow T, Ryan MP. Cyclosporine A-induced renal fibrosis: a role for epithelial-mesenchymal transition. Am J Pathol 2005;167:395-407.
34. Toso C, Baertschiger R, Morel P, Bosco D, Armanet M, Wojtusciszyn A, et al. Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol. Am J Transplant 2006;6: 1049-1058.