Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4- dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus

Epilepsia

Volumn 48, Issue 4, 2007, Pages 783-792

  Jiang, Feng Li ^a   Tang, Yong Cheng ^a   Chia, Shwn Chin ^a   Jay, Therese M ^c   Tang, Feng Ru ^a,b  

^a NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c INSERM   (France)

Author keywords

S 3,4 DCPG; Status epilepticus; Temporal lobe epilepsy

Indexed keywords

3,4 DICARBOXYPHENYLGLYCINE; METABOTROPIC RECEPTOR 8; METABOTROPIC RECEPTOR AGONIST; PILOCARPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DENTATE GYRUS; DISEASE DURATION; DOSE RESPONSE; DRUG DOSE COMPARISON; EPILEPTIC STATE; EVOKED SOMATOSENSORY RESPONSE; EXCITATORY POSTSYNAPTIC POTENTIAL; GRANULAR CELL; MALE; MOUSE; NERVE CELL; NEUROPHYSIOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TEMPORAL LOBE EPILEPSY;

ANIMALS; ANTICONVULSANTS; BENZOATES; DENTATE GYRUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EPILEPSY, TEMPORAL LOBE; EXCITATORY POSTSYNAPTIC POTENTIALS; GLYCINE; HIPPOCAMPUS; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; MICE; NEURAL INHIBITION; NEURONS; PERFORANT PATHWAY; PILOCARPINE; RECEPTORS, METABOTROPIC GLUTAMATE; STATUS EPILEPTICUS;

EID: 34247169976     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01000.x     Document Type: Article

References (48)

1. Andersen P, Bliss TVP, Skrede KK. (1971) Unit analysis of hippocampal population spikes. Experimental Brain Research 13:208-221.
2. Andre V, Marescaux C, Nehlig A, Fritschy JM. (2001) Alterations of hippocampal GABAergic system contribute to spontaneous recurrent seizures in the rat lithium pilocarpine model of temporal lobe epilepsy. Hippocampus 11:452-468.
3. Babb TL, Pretorius JK, Kupfer WR, Crandall PH. (1989) Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. Journal of Neuroscience 9:2562-2574.
4. Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Levesque MF. (1991) Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience 42:351-363.
5. Barton ME, Peters SC, Shannon HE. (2003) Comparison of the effect of glutamate receptor modulators in the 6Hz and maximal electroshock seizure models. Epilepsy Research 56:17-26.
6. Bough KJ, Mott DD, Dingledine RJ. (2004) Medial perforant path inhibition mediated by mGluR7 is reduced after status epilepticus. Journal of Neurophysiology 92:1549-1557.
7. Buckmaster PS, Dudek FE. (1997) Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainite-treated rats. Journal of Comparative Neurology 385:385-404.
8. Chapman AG, Nanan K, Yip P, Meldrum BS. (1999) Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, (R,S)-4- phosphonophenylglycine. European Journal of Pharmacology 383:23-27.
9. Davenport CJ, Brown WJ, Babb TL. (1990) Sprouting of GABAergic and mossy fiber axons in dentate gyrus following intrahippocampal kainate in the rat. Experimental Neurology 109:180-190.
10. Dietrich D, Beck H, Kral T, Clusmann H, Elger CE, Schramm J. (1997) Metabotropic glutamate receptors modulate synaptic transmission in the perforant path: pharmacology and localization of two distinct receptors. Brain Research 767:220-227.
11. Dietrich D, Kral T, Clusmann H, Friedl M, Schramm J. (1999) Reduced function of L-AP4-sensitive metabotropic glutamate receptors in human epileptic sclerotic hippocampus. European Journal of Neuroscience 11:109-113.
12. Ferraguti F, Klausberger T, Cobden P, Baude A, Roberts JD, Szucs P, Kinoshita A, Shigemoto R, Somogyi P, Dalezios Y. (2005) Metabotropic glutamate receptor 8-expressing nerve terminals target subsets of GABAergic neurons in the hippocampus. Journal of Neuroscience 25:10520-10536.
13. Friedl M, Clusmann H, Kral T, Dietrich D, Schramm J. (1999) Analysing metabotropic glutamate group III receptor mediated modulation of synaptic transmission in the amygdala-kindled dentate gyrus of the rat. Brain Research 821:117-123.
14. Gasparini F, Bruno V, Battaglia G, Lukic S, Leonhardt T, Inderbitzin W, Laurie D, Sommer B, Varney MA, Hess SD, Johnson EC, Kuhn R, Urwyler S, Sauer D, Portet C, Schmutz M, Nicoletti F, Flor PJ. (1999) (R,S)-4- phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. Journal of Pharmacology and Experimental Therapeutics 289:1678-1687.
15. Ghauri M, Chapman AG, Meldrum BS. (1996) Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs. Neuroreport 7:1469-1474.
16. Gibbs III JW, Shumate MD, Coulter DA. (1997) Differential epilepsy associated alterations in postsynaptic GABAA receptor function in dentate granule and CA1 neurons. Journal of Neurophysiology 77:1924-1938.
17. Haas KZ, Sperber EF, Moshe SL, Stanton PK. (1996) Kainic acidinduced seizures enhance dentate gyrus inhibition by downregulation of GABAB receptors. Journal of Neuroscience 16:4250-4260.
18. Harvey BD, Sloviter RS. (2005) Hippocampal granule cell activity and c-Fos expression during spontaneous seizures in awake, chronically epileptic pilocarpine-treated rats: implications for hippocampal epileptogenesis. Journal of Comparative Neurology 488:442-463.
19. Isokawa-Akesson M, Wilson CE, Babb TL. (1989) Inhibition in synchronously firing human hippocampal neurons. Epilepsy Research 3:236-247.
20. Klapstein GJ, Meldrum BS, Mody I. (1999) Decreased sensitivity to group III mGluR agonists in the lateral perforant path following kindling. Neuropharmacology 38:927-933.
21. Kobayashi M, Buckmaster PS. (2003) Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy. Journal of Neuroscience 23:2440-2452.
22. Kotti T, Riekkinen PJ Sr, Miettinen R. (1997) Characterization of target cells for aberrant mossy fiber collaterals in the dentate gyrus of epileptic rat. Experimental Neurology 146:323-330.
23. Kral T, Erdmann E, Sochivko D, Clusmann H, Schramm J, Dietrich D. (2003) Down-regulation of mGluR8 in pilocarpine epileptic rats. Synapse 47:278-284.
24. Lømo T. (1971) Patterns of activation in a monosynaptic cortical pathway: the perforant path input to the dentate area of he hippocampal formation. Experimental Brain Research 12:18-45.
25. Lee JJ, Jane DE, Croucher MJ. (2003) Anticonvulsant dicarboxyphenyl- glycines differentially modulate excitatory amino acid release in the rat cerebral cortex. Brain Research 977:119-123.
26. Mathern GW, Bertram EH III, Babb TL, Pretorius JK, Kuhlman PA, Spradlin S, Mendoza D. (1997) In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting and increased staining for N-methyl-D-aspartate, AMPA and GABAA receptors. Neuroscience 77:1003-1019.
27. Milgram NW, Yearwood T, Khurgel M, Ivy GO, Racine R. (1991) Changes in inhibitory processes in the hippocampus following recurrent seizures induced by systemic administration of kainic acid. Brain Research 551:230-240.
28. Moldrich RX, Beart PM, Jane DE, Chapman AG, Meldrum BS. (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40:732-735.
29. Paxinos G, Franklin KBJ. (1997) The mouse brain in stereotaxic coordinates. Academic Press, San Diego, Ca.
30. Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor PJ, Neki A, Abe T, Nakanishi S, Mizuno N. (1997) Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. Journal of Neuroscience 17:7503-7522.
31. Sloviter RS. (1987) Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy. Science 235:73-76.
32. Sloviter RS. (1992) Possible functional consequences of synaptic reorganization in the dentate gyrus of kainate-treated rats. Neuroscience Letters 137:91-96.
33. Sutula T, He XX, Cavazos J, Scott G. (1988) Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science 239:1147-1150.
34. Suzuki K, Mori N, Kittaka H, Iwata Y, Yamada Y, Osonoe K, Niwa S. (1996) Anticonvulsant action of metabotropic glutamate receptor agonists in kindled amygdala of rats. Neuroscience Letters 204:41-44.
35. Tang E, Yip PK, Chapman AG, Jane DE, Meldrum BS. (1997) Prolonged anticonvulsant action of glutamate metabotropic receptor agonists in inferior colliculus of genetically epilepsy-prone rats. European Journal of Pharmacology 327:109-15.
36. Tang FR, Lee WL. (2001a) Expression of the group II and III metabotropic glutamate receptors in the hippocampus of patients with mesial temporal lobe epilepsy. Journal of Neurocytology 30:135-141.
37. Tang FR, Lee WL, Yang J, Sim MK, Ling EA. (2001b) Metabotropic glutamate receptor 8 in the rat hippocampus after pilocarpine induced status epilepticus. Neuroscience Letters 300:137-140.
38. Tang FR, Chia SC, Chen PM, Gao H, Lee WL, Yeo TS, Burgunder JM, Probst A, Sim MK, Ling EA. (2004) Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus. Epilepsy Research 59:167-180.
39. Tang FR, Chia SC, Zhang S, Chen PM, Gao H, Liu CP, Khanna S, Li WL. (2005) Glutamate receptor 1-immunopositive neurons in the gliotic CA1 area of the mouse hippocampus after pilocarpine-induced status epilepticus. European Journal of Neuroscience 21:2361-2374.
40. Tauck DL, Nadler JV. (1985) Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid treated rats. Journal of Neuroscience 5:1016-1022.
41. Tuff LP, Racine RJ, Adamec R. (1983) The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat, I: paired-pulse depression. Brain Research 277:79-90.
42. Uruno K, O'Connor MJ, Masukawa LM. (1995) Effects of bicuculline and baclofen on paired-pulse depression in the dentate gyrus of epileptic patients. Brain Research 695:163-172.
43. Wenzel HJ, Woolley CS, Robbins CA, Schwartzkroin PA. (2000) Kainic acid-induced mossy fiber sprouting and synapse formation in the dentate gyrus of rats. Hippocampus 10:244-260.
44. Wilson CL, Khan SU, Engel Jr J, Isokawa M, Babb TL, Behnke EJ. (1998) Paired pulse suppression and facilitation in human epileptogenic hippocampal formation. Epilepsy Research 31:211-230.
45. Wittner L, Magloczky Z, Borhegyi Z, Halasz P, Toth S, Eross L, Szabo Z, Freund TF. (2001) Preservation of perisomatic inhibitory input of granule cells in the epileptic human dentate gyrus. Neuroscience 108:587-600.
46. Wu K, Leung LS. (2001) Enhanced but fragile inhibition in the dentate gyrus in vivo in the kainic acid model of temporal lobe epilepsy: a study using current source density analysis. Neuroscience 104:379-396.
47. Zhai J, Tian MT, Wang Y, Yu JL, Koster A, Baez M, Nisenbaum ES. (2002) Modulation of lateral perforant path excitatory responses by metabotropic glutamate 8 (mGlu8) receptors. Neuropharmacology 43:223-230.
48. Tizzano JP, Griffey KI, Schoepp DD. (1995) Induction or protection of limbic seizures in mice by mGluR subtype selective agonists. Neuropharmacology 34:1063-1067.