Short term protective effects of iron in a murine model of ischemia/reperfusion

BioMetals

Volumn 20, Issue 2, 2007, Pages 205-215

  Metzler, Bernhard ^a   Jehle, Johannes ^a   Theurl, Igor ^a   Ludwiczek, Susanne ^a   Obrist, Peter ^b   Pachinger, Otmar ^a   Weiss, Günter ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b Departement of Pathology   (Austria)

Author keywords

Iron; Myocardial infarction; Nitric oxide; Superoxide dismutase; Tumor necrosis factor

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; IRON DEXTRAN; NITRIC OXIDE; RADICAL; SUPEROXIDE DISMUTASE; TROPONIN T; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; EXPERIMENTAL MODEL; HEART INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REPERFUSION INJURY; TREATMENT OUTCOME;

ANIMALS; IRON; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL ISCHEMIA; NITRIC OXIDE SYNTHASE TYPE II; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

ANIMALIA; MURINAE; MUS;

EID: 34247169072     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-006-9034-y     Document Type: Article

References (44)

1. Adamcova M, Machackova J, Gersl V, et al. 2002 Cardiac troponin T following repeated administration of pyridoxal isonicotinoyl hydrazone in rabbits. Physiol Res 51, 443-448.
2. Baer DM, Tekawa IS, Hurley LB. 1994 Iron stores are not associated with acute myocardial infarction. Circulation 89, 2915-2918.
3. Bernard M, Menasche P, Pietri S, Piwnica A, Cozzone PJ. 1988 Cardioplegic arrest superimposed on evolving myocardial ischemia. Improved recovery after inhibition of hydroxyl radical generation by peroxidase or deferoxamine. A 31P nuclear resonance study. Circulation 78, 164-172.
4. Bolli R, Patel BS, Jeroudi MO, et al. 1990 Iron-mediated radical reactions upon reperfusion contribute to myocardial "stunning". Am J Physiol 259, H1901-H1911.
5. Bogdan C. 2001 Nitric oxide and the immune response. Nat Immunol 2, 907-916.
6. Chauhan SD, Seggara G, Vo PA, Macallister RJ, Hobbs AJ, Ahluwalia A. 2003 Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. FASEB J 17, 773-775.
7. Dlaska M, Weiss G. 1999 Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible nitric oxide synthase expression. J Immunol 162, 6171-6177.
8. Drapier JC, Hibbs JB Jr. 1988 Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells. J Immunol 140, 2829-2838.
9. Foster MW, McMahon TJ, Stamler JS. 2003 S-nitrosylation in health and disease. Trends Mol Med 9, 160-168.
10. Ferdinandy P, Schulz R. 2003 Nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury and preconditioning. Br J Pharmacol 138, 532-543.
11. Gaenzer H, Marschang P, Sturm W, Vogel W, Patsch J, Weiss G. 2002 Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol 40, 2189-2194.
12. Galinanes M, Fowler AG. 2004 Role of clinical pathologies in myocardial injury following ischaemia and reperfusion. Cardiovasc Res 61, 512-521.
13. Gastl G, Spizzo G, Obrist P, Dünser M, Mikuz G. 2000 Ep-CAM overexpression in breast cancer as a predictor of survival. Lancet 356, 1981-1982.
14. Griendling KK, Alexander RW. 1997 Oxidative stress and cardiovascular disease. Circulation 96, 3264-3265.
15. Jones PL, Boss JM. 1997 Tumor necrosis factor alpha and interleukin-1 beta regulate the murine manganese superoxide dismutase gene through a complex inotronic enhancer involving C/EBP-beta and NF-kB. Mol Cell Biol 17, 6970-6981.
16. Kiechl S, Willeit J, Egger G, Poewe W, Oberhollenzer F. 1997 Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study. Circulation 96, 3300-3307.
17. Kurrelmeyer KM, Michael L, Baumgarten G, et al. 2000 Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction. Proc Natl Acad Sci USA 100, 5456-5461.
18. Lancel S, Tissier S, Mordon S, et al. 2004 Peroxynitrite decompositon catalysts prevent myocardical dysfunction and inflamamtion in endotoxemic rats. J Am Coll Cardiol 43, 2348-2358.
19. Liao Y, Cooper RS, McGee DL. 1994 Iron status and coronary heart disease: negative findings from the NHANES I epidemilogic follow-up study. Am J Epidemiol 139, 704-712.
20. Ludwiczek S, Theurl I, Artner-Dworzak E, Chorney M, Weiss G. 2004 Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability. J Mol Med 82, 373-382.
21. Melillo G, Taylor LS, Brooks A, Musso T, Cox GW, Varesio L. 1997 Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine. J Biol Chem 272, 12236-12243.
22. Metzler B, Mair J, Lercher A, Hintringer F, Pachinger O, Xu Q. 2001 Mouse model of myocardial remodeling after ischemia: role of intercellular adhesion molecule-1. Cardivasc Res 49, 399-407.
23. Metzler B, Hammerer-Lercher A, Jehle J, et al. 2002 Plasma cardiac troponin T closely correlates with infarct size in a mouse model of acute myocardial infarction. Clin Chim Acta 325, 87-90.
24. Michael LH, Entman ML, Youker KA. 1995 Myocardial ischemia and reperfusion: a murine model. Am J Physiol 269, H2147-H2154.
25. Moncada S. 1997 Nitric oxide in the vasculature: physiology and pathophysiology. Ann NY Acad Sci 811, 60-67.
26. Morita K, Ihnken K, Buckberg GD, Sherman MP, Young HH, Ignarro LJ. 1994 Role of controlled cardiac reoxygenation in reducing nitric oxide production and cardiac oxidant damage in cyanotic infantile hearts. J Clin Invest 93, 2658-2666.
27. Mungrue IM, Gros R, You X, et al. 2002 Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest 109, 735-743.
28. Naranjan S, Dhalla S, Makino N. 2000 Status of myocardial antioxidants in ischemia reperfusion injury. Cardiovasc Res 47, 446-456.
29. Nathan C, Xie QW. 1994 Nitric oxide synthases: roles, tolls, and controls. Cell 78, 915-918.
30. Palacios-Callender M, Quintero M, Hollis VS, Springett RJ, Moncada S. 2004 Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proc Natl Acad Sci USA 101, 7630-7635.
31. Papanikolaou G, Pantopoulos K. 2005 Iron metabolism and toxicity. Toxicol Appl Pharmacol 202, 199-211.
32. Pietrangelo A. 2004 Hereditary hemochromatosis - a new look at an old disease. N Engl J Med 350, 2383-2397.
33. Sack MN, Smith RM, Opie LH. 2000 Tumor necrosis factor in myocardial hypertrophy and ischemia - an anti-apoptotic perspective. Cardiovasc Res 3, 688-695.
34. Saito T, Hu F, Tayara L, Fahas L, Shennib H, Giaid A. 2002 Inhibition of NOS II prevents cardiac dysfunction in myocardial infarction and congestive heart failure. Am J Physiol Heart Circ Physiol 283, H339-H345.
35. Schneider BD, Leibold EA. 2003 Effects of iron regulatory protein regulation on iron homeostasis during hypoxia. Blood 102, 3404-3411.
36. Strieter RM, Bone RC. 1993 Role of tumor necrosis factor in disease states and inflammation. Crit Care Med 21, S447-S463.
37. Theurl I, Ludwiczek S, Fritsche G, Garimorth K, Bellman-Weiler R, Weiss G. 2005 The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections. Biometals 18, 359-367.
38. Tuomainen TP, Kontula K, Nyssonen K, Lakka TA, Helio T, Salonen JT. 1999 Increased risk of acute myocardial infarction in carriers of the hemochromatosis gen Cys282Tyr mutation: a prospective cohort study in men in eastern Finland. Circulation 100, 1274-1279.
39. Turoczi T, Jun L, Cordis G, et al. 2003 HFE mutation and dietary iron content interact to increase ischemia/reperfusion injury of the heart in mice. Circ Res 92, 1240-1246.
40. Verma S, Fedak PW, Weisel RD, et al. 2002 Fundamentals of reperfusion injury for the clinical cardiologist. Circulation 100, 2332-2336.
41. Warner BB, Wispe JR. 1996 Redox regulation of manganese superoxide dismutase. Am J Physiol 271, L150-L158.
42. Weiss G, Goossen B, Doppler W, et al. 1993 Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway. EMBO J 12, 3651-3657.
43. Weiss G, Werner-Felmayer G, Werner ER, Grunewald K, Wachter H, Hentze MW. 1994 Iron regulates nitric oxide synthase activity by controlling nuclear transcription. J Exp Med 180, 969-976.
44. Zingarelli B, Salzman AL, Szabo C. 1998 Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res 83, 85-94.