Directed catalytic asymmetric olefin metathesis. Selectivity control by enoate and ynoate groups in Ru-catalyzed asymmetric ring-opening/cross- metathesis

Journal of the American Chemical Society

Volumn 129, Issue 13, 2007, Pages 3824-3825

  Giudici, Russell E ^a   Hoveyda, Amir H ^a  

^a BOSTON COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE DERIVATIVE; RUTHENIUM;

ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; RING OPENING METATHESIS POLYMERIZATION;

EID: 34247151186     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja070187v     Document Type: Article

References (24)

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11. This suggests that phosphine-bearing Ru carbenes would likely not be effective in implementing this strategy (cf. ref 2b).
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15. NMR experiments indicate the rapid formation (>98% conversion) of a new carbene upon treatment of 1 with 6. When complex 6 is treated with styrene, significant amounts of unreacted carbene remain after 24 h.
16. 1H NMR. Isolation and determination of the corresponding E/Z and % ee, data that may shed light on the mechanism of catalyst initiation, are in progress.
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21. Preliminary studies indicate that cyclopropene substituents must be significantly different in size for high enantioselectivity to be achieved.
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