The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons

European Journal of Pharmacology

Volumn 563, Issue 1-3, 2007, Pages 117-123

  Dai, Haibin ^a,b   Fu, Qiuli ^a   Shen, Yao ^a   Hu, Weiwei ^a   Zhang, Zhongmiao ^b   Timmerman, Henk ^c   Leurs, Rob ^c   Chen, Zhong ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Clobenpropit; Excitotoxicity; GABA; Histamine H3 receptor; Intracellular calcium level; NMDA

Indexed keywords

4 AMINOBUTYRIC ACID; 9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE INHIBITOR; ALPHA METHYLHISTAMINE; BICUCULLINE; CALCIUM; CIMETIDINE; CLOBENPROPIT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; HISTAMINE H3 RECEPTOR AGONIST; HISTAMINE H3 RECEPTOR ANTAGONIST; MEPYRAMINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N METHYL DEXTRO ASPARTIC ACID; PICROTOXIN; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; ANTIHISTAMINIC AGENT; DRUG DERIVATIVE; HISTAMINE AGONIST; HISTAMINE H3 RECEPTOR; IMIDAZOLE DERIVATIVE; N METHYLASPARTIC ACID; NEUROPROTECTIVE AGENT; PROTEIN KINASE INHIBITOR; THIOUREA;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; EXCITOTOXICITY; INHIBITION KINETICS; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN CORTEX; CELL PROTECTION; CELL SURVIVAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; NECROSIS; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; IMIDAZOLES; N-METHYLASPARTATE; NECROSIS; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3; THIOUREA;

EID: 34247148574     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.01.069     Document Type: Article

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