Parental smoking modifies the relation between genetic variation in tumor necrosis factor-α (TNF) and childhood asthma

Environmental Health Perspectives

Volumn 115, Issue 4, 2007, Pages 616-622

  Wu, Hao ^a   Romieu, Isabelle ^b   Sienra Monge, Juan Jose ^c   del Rio Navarro, Blanca Estela ^c   Anderson, Daniel M ^a   Dunn, Erin W ^a   Steiner, Lori L ^d   Lara Sanchez, Irma del Carmen ^b   London, Stephanie J ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b INSTITUTO NACIONAL DE SALUD PÚBLICA   (Mexico)

^c HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^d ROCHE MOLECULAR SYSTEMS   (United States)

Author keywords

Allergy; Asthma; Atopy; Environmental tobacco smoke; Genetic predisposition todisease; Lymphotoxin (LTA); Ozone; Secondhand smoke; Single nucleotide polymorphism(SNP); Tumor necrosis factor (TNF)

Indexed keywords

ANTIASTHMATIC AGENT; LYMPHOTOXIN; OZONE; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ALLELE; ARTICLE; ASTHMA; ATOPY; CHILD; CONFIDENCE INTERVAL; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MEXICO; NUCLEAR FAMILY; NUCLEOTIDE SEQUENCE; PARENTAL SMOKING; PRICK TEST; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; ASTHMA; CHILD; CHILD, PRESCHOOL; ENVIRONMENTAL EXPOSURE; FEMALE; GENOTYPE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; LYMPHOTOXIN-ALPHA; MALE; MEXICO; OZONE; PARENT-CHILD RELATIONS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; TOBACCO SMOKE POLLUTION; TUMOR NECROSIS FACTOR-ALPHA;

NICOTIANA TABACUM;

EID: 34247139812     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9740     Document Type: Article

References (77)

1. Aas K, Belin L. 1973. Standardization of diagnostic work in allergy. Int Arch Allergy Appl Immunol 45:57-60.
2. Albuquerque RV, Hayden CM, Palmer LJ, Laing IA, Rye PJ, Gibson NA, et al. 1998. Association of polymorphisms within the tumour necrosis factor (TNF) genes and childhood asthma. Clin Exp Allergy 28:578-584.
3. Arsalane K, Gosset P, Vanhee D, Voisin C, Hamid Q, Tonnel AB, et al. 1995. Ozone stimulates synthesis of inflammatory cytokines by alveolar macrophages in vitro. Am J Respir Cell Mol Biol 13:60-68.
4. ATS (American Thoracic Society). 1995. Standardization of spirometry, 1994 update, American Thoracic Society. Am J Respir Crit Care Med 152:1107-1136.
5. Babu KS, Davies DE, Holgate ST. 2004. Role of tumor necrosis factor alpha in asthma. Immunol Allergy Clin North Am 24:583-597, v-vi.
6. Barcellos LF, Begovich AB, Reynolds RL, Caillier SJ, Brassat D, Schmidt S, et al. 2004. Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. Ann Neurol 55:793-800.
7. Beghe B, Padoan M, Moss CT, Barton SJ, Holloway JW, Holgate ST, et al. 2004. Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma. Allergy 59:61-64.
8. Belousov YS, Welch RA, Sanders S, Mills A, Kulchenko A, Dempcy R, et al. 2004. Single nucleotide polymorphism genotyping by two colour melting curve analysis using the MGB Eclipse Probe System in challenging sequence environment. Hum Genomics 1:209-217.
9. Bilolikar H, Nam AR, Rosenthal M, Davies JC, Henderson DC, Balfour-Lynn IM. 2005. Tumour necrosis factor gene polymorphisms and childhood wheezing. Eur Respir J 26:637-646.
10. Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R, et al. 1994. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 10:471-480.
11. BTS/SIGN (British Thoracic Society/Scottish Intercollegiate Guidelines Network). 2003. British guideline on the management of asthma. Thorax 58(suppl 1):i1-i94.
12. Buckova D, Holla LI, Vasku A, Znojil V, Vacha J. 2002. Lack of association between atopic asthma and the tumor necrosis factor alpha-308 gene polymorphism in a Czech population. J Investig Allergol Clin Immunol 12:192-197.
13. Cardaba B, Moffatt MF, Fernandez E, Jurado A, Rojo M, Garcia M, et al. 2001. Allergy to dermatophagoides in a group of Spanish gypsies: genetic restrictions. Int Arch Allergy Immunol 125:297-306.
14. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. 2004. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 74:106-120.
15. Chagani T, Pare PD, Zhu S, Weir TD, Bai TR, Behbehani NA, et al. 1999. Prevalence of tumor necrosis factor-alpha and angiotensin converting enzyme polymorphisms in mild/moderate and fatal/near-fatal asthma. Am J Respir Crit Care Med 160:278-282.
16. Churg A, Wang RD, Tai H, Wang X, Xie C, Dai J, et al. 2003. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med 167:1083-1089.
17. Colilla S, Nicolae D, Pluzhnikov A, Blumenthal MN, Beaty TH, Bleecker ER, et al. 2003. Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol 111:840-846.
18. CSGA. 1997. A genome-wide search for asthma susceptibility loci in ethnically diverse populations. The Collaborative Study on the Genetics of Asthma (CSGA). Nat Genet 15:389-392.
19. Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, et al. 1996. A genome-wide search for quantitative trait loci underlying asthma. Nature 383:247-250.
20. David GL, Romieu I, Sienra-Monge JJ, Collins WJ, Ramirez-Aguilar M, del Rio-Navarro BE, et al. 2003. Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma. Am J Respir Crit Care Med 168:1199-1204.
21. DHHS. 2006. The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health.
22. Di Somma C, Charron D, Deichmann K, Buono C, Ruffilli A. 2003. Atopic asthma and TNF-308 alleles: linkage disequilibrium and association analyses. Hum Immunol 64:359-365.
23. El Bahlawan L, Christensen M, Binaei S, Murphy C, Zhang Q, Quasney M. 2003. Lack of association between the tumor necrosis factor-alpha regulatory region genetic polymorphisms associated with elevated tumor necrosis factor-alpha levels and children with asthma. Chest 123(suppl 3):374S-375S.
24. Fong CL, Mark DF. 1995. The NF-kappa B-like site in the TNF-alpha repressor element is essential for its repressor function. Biochem Biophys Res Commun 212:879-886.
25. Gao J, Shan G, Sun B, Thompson PJ, Gao X. 2006. Association between polymorphism of tumour necrosis factor alpha-308 gene promoter and asthma: a meta-analysis. Thorax 61:466-471.
26. Gjessing HK, Lie RT. 2005. Case-parent triads: estimating single- and double-dose effects of fetal and maternal disease gene haoplotypes. Ann Hum Genet 70:382-396.
27. Gonzalez-Neira A, Ke X, Lao O, Calafell F, Navarro A, Comas D, et al. 2006. The portability of tagSNPs across populations: a worldwide survey. Genome Res 16:323-330.
28. Gupta V, Sarin BC, Changotra H, Sehajpal PK. 2005. Association of G-308A TNF-alpha polymorphism with bronchial asthma in a north Indian population. J Asthma 42:839-841.
29. Horvath S, Xu X, Laird NM. 2001. The family based association test method: strategies for studying general genotype - phenotype associations. Eur J Hum Genet 9(4):301-306.
30. Immervoll T, Loesgen S, Dutsch G, Gohlke H, Herbon N, Klugbauer S, et al. 2001. Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes. Hum Mutat 18:327-336.
31. Izakovicova Holla L, Vasku A, Izakovic V, Znojil V. 2001. The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin alpha (LT-alpha) genes and atopic diseases in the Czech population. Clin Exp Allergy 31:1418-1423.
32. Kips JC, Tavernier J, Pauwels RA. 1992. Tumor necrosis factor causes bronchial hyperresponsiveness in rats. Am Rev Respir Dis 145(2 Pt 1):332-336.
33. Kistner EO, Weinberg CR. 2004. Method for using complete and incomplete trios to identify genes related to a quantitative trait. Genet Epidemiol 27:33-42.
34. Kleeberger SR, Levitt RC, Zhang LY, Longphre M, Harkema J, Jedlicka A, et al. 1997. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice. Nat Genet 17:475-478.
35. Knight JC, Keating BJ, Kwiatkowski DP. 2004. Allele-specific repression of lymphotoxin-alpha by activated B cell factor-1. Nat Genet 36:394-399.
36. Kroeger KM, Carville KS, Abraham LJ. 1997. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol 34:391-399.
37. Lake SL, Laird NM. 2004. Tests of gene-environment interaction for case-parent triads with general environmental exposures. Ann Hum Genet 68(Pt 1):55-64.
38. Li H, Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Estela Del Rio-Navarro B, Kistner EO, et al. 2006. Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol 117:119-126.
39. Li YF, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. 2006. Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. Am J Respir Crit Care Med 173:970-976.
40. Li Kam Wa TC, Mansur AH, Britton J, Williams G, Pavord I, Richards K, et al. 1999. Association between -308 tumour necrosis factor promoter polymorphism and bronchial hyperreactivity in asthma. Clin Exp Allergy 29:1204-1208.
41. Lin YC, Lu CC, Su HJ, Shen CY, Lei HY, Guo YL. 2002. The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents. Allergy 57:831-834.
42. Louis E, Franchimont D, Piron A, Gevaert Y, Schaaf-Lafontaine N, Roland S, et al. 1998. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 113:401-406.
43. Louis R, Leyder E, Malaise M, Bartsch P, Louis E. 2000. Lack of association between adult asthma and the tumour necrosis factor alpha-308 polymorphism gene. Eur Respir J 16:604-608.
44. Martinez FD. 2005. Gene-environment interactions in asthma and allergies: a new paradigm to understand disease causation. Immunol Allergy Clin North Am 25:709-721.
45. Messer G, Spengler U, Jung MC, Honold G, Blomer K, Pape GR, et al. 1991. Polymorphic structure of the tumor necrosis factor (TNF) locus: an Ncol polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production. J Exp Med 173:209-219.
46. Migita O, Noguchi E, Koga M, Jian Z, Shibasaki M, Migita T, et al. 2005. Haplotype analysis of a 100 kb region spanning TNF-LTA identifies a polymorphism in the LTA promoter region that is associated with atopic asthma susceptibility in Japan. Clin Exp Allergy 35:790-796.
47. Moffatt MF, Cookson WO. 1997. Tumour necrosis factor haplotypes and asthma. Hum Mol Genet 6:551-554.
48. Moffatt MF, James A, Ryan G, Musk AW, Cookson WO. 1999. Extended tumour necrosis factor/HLA-DR haplotypes and asthma in an Australian population sample. Thorax 54:757-761.
49. NHLBI (National Heart, Lung, and Blood Institute). 1998. Pocket Guide for Asthma Management and Prevention: Global Initiative for Asthma. Bethesda, MD:National Institutes of Health.
50. Noguchi E, Yokouchi Y, Shibasaki M, Inudou M, Nakahara S, Nogami T, et al. 2002. Association between TNFA polymorphism and the development of asthma in the Japanese population. Am J Respir Crit Care Med 166:43-46.
51. O'Connell JR, Weeks DE. 1998. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266.
52. Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, et al. 2002. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 32:650-654.
53. Packer BR, Yeager M, Staats B, Welch R, Crenshaw A, Kiley M, et al. 2004. SNP500Cancer: a public resource for sequence validation and assay development for genetic variation in candidate genes. Nucleic Acids Res 32(Database issue):D528-D532.
54. Park GY, Park JW, Jeong DH, Jeong SH. 2003. Prolonged airway and systemic inflammatory reactions after smoke inhalation. Chest 123:475-480.
55. Perez-Padilla R, Regalado-Pineda J, Rojas M, Catalan M, Mendoza L, Rojas R, et al. 2003. Spirometric function in children of Mexico City compared to Mexican-American children. Pediatr Pulmonol 35:177-183.
56. Randolph AG, Lange C, Silverman EK, Lazarus R, Weiss ST. 2005. Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am J Respir Crit Care Med 172:687-692.
57. Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Tellez-Rojo MM, Moreno-Macias H, Reyes-Ruiz NI, et al. 2002. Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants. Am J Respir Crit Care Med 166:703-709.
58. Sandford AJ, Chan HW, Wong GW, Lai CK, Chan-Yeung M. 2004. Candidate genetic polymorphisms for asthma in Chinese schoolchildren from Hong Kong. Int J Tuberc Lung Dis 8:519-527.
59. Sharma S, Sharma A, Kumar S, Sharma SK, Ghosh B. 2006. Association of TNF haplotypes with asthma, serum IgE levels and correlation with serum TNF-alpha levels. Am J Respir Cell Mol Biol 35:488-495.
60. Shin HD, Park BL, Kim LH, Jung JH, Wang HJ, Kim YJ, et al. 2004. Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. Hum Mol Genet 13:397-403.
61. Stephens M, Smith NJ, Donnelly P. 2001. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989.
62. Storey JD, Tibshirani R. 2003. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100: 9440-9445.
63. Tatum AJ, Shapiro GG. 2005. The effects of outdoor air pollution and tobacco smoke on asthma. Immunol Allergy Clin North Am 25:15-30.
64. Thomas PS. 2001. Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. Immunol Cell Biol 79:132-140.
65. Thomas PS, Yates DH, Barnes PJ. 1995. Tumor necrosis factor-alpha increases airway responsiveness and sputum neutrophilia in normal human subjects. Am J Respir Crit Care Med 152:76-80.
66. Trabetti E, Patuzzo C, Malerba G, Galavotti R, Martinati LC, Boner AL, et al. 1999. Association of a lymphotoxin alpha gene polymorphism and atopy in Italian families. J Med Genet 36:323-325.
67. Umbach DM, Weinberg CR. 2000. The use of case-parent triads to study joint effects of genotype and exposure. Am J Hum Genet 66:251-261.
68. Van Hage-Hamsten M, Johansson E, Kronqvist M, Loughry A, Cookson WO, Moffatt MF. 2002. Associations of Fc epsilon R1-beta polymorphisms with immunoglobin E antibody responses to common inhalant allergens in a rural population. Clin Exp Allergy 32:838-842.
69. Wang TN, Chen WY, Wang TH, Chen CJ, Huang LY, Ko YC. 2004. Gene-gene synergistic effect on atopic asthma: tumour necrosis factor-alpha-308 and lymphotoxin-alpha-Ncol in Taiwan's children. Clin Exp Allergy 34:184-188.
70. Weinberg CR, Wilcox AJ, Lie RT. 1998. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 62:969-978.
71. Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, et al. 2005. TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. Am J Respir Crit Care Med 172:1563-1568.
72. Wilcox AJ, Weinberg CR, Lie RT. 1998. Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads." Am J Epidemiol 148:893-901.
73. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. 1997. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 94:3195-3199.
74. Winchester EC, Millwood IY, Rand L, Penny MA, Kessling AM. 2000. Association of the TNF-alpha-308 (G→A) polymorphism with self-reported history of childhood asthma. Hum Genet 107:591-596.
75. Witte JS, Palmer LJ, O'Connor RD, Hopkins PJ, Hall JM. 2002. Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma. Eur J Hum Genet 10:82-85.
76. Yang IA, Holz O, Jorres RA, Magnussen H, Barton SJ, Rodriguez S, et al. 2005. Association of tumor necrosis factor-alpha polymorphisms and ozone-induced change in lung function. Am J Respir Crit Care Med 171:171-176.
77. Zhu S, Chan-Yeung M, Becker AB, Dimich-Ward H, Ferguson AC, Manfreda J, et al. 2000. Polymorphisms of the IL-4, TNF-alpha, and Fcepsilon RIbeta genes and the risk of allergic disorders in at-risk infants. Am J Respir Crit Care Med 161:1655-1659.