Remodeling of carotid arteries is associated with increased expression of thrombomodulin in a mouse transverse aortic constriction model

Thrombosis and Haemostasis

Volumn 97, Issue 4, 2007, Pages 658-664

  Li, Yi Heng ^a,b   Hsieh, Chung Yu ^c   Wang, Danny Ling ^c   Chung, Hsing Chun ^a,b   Liu, Shu Lin ^a,b   Chao, Ting Hsing ^a,b   Shi, Guey Yueh ^a,b   Wu, Hua Lin ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

Author keywords

Arterial remodeling; Atherosclerosis; Thrombomodulin

Indexed keywords

MESSENGER RNA; THROMBOMODULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTERY MEDIA; ARTERY WALL; ARTICLE; CAROTID ARTERY OBSTRUCTION; CELL CULTURE; CONTROLLED STUDY; DOPPLER FLOWMETRY; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; MORPHOMETRICS; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEAR STRESS; STATISTICAL SIGNIFICANCE;

ANIMALS; AORTA, THORACIC; AORTIC DISEASES; BLOOD FLOW VELOCITY; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CELLS, CULTURED; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LASER-DOPPLER FLOWMETRY; LIGATION; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, MECHANICAL; THROMBOMODULIN; TIME FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 34247120667     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH06-12-0690     Document Type: Article

References (27)

1. Resnick N, Yahav H, Shay-Salit A, et al. Fluid shear stress and the vascular endothelium: for better and for worse. Prog Biophys Mol Biol 2003; 81: 177-199.
2. Pasterkamp, G, Galis ZS, de Kleijn DR Expansive arterial remodeling: location, location, location. Arterioscler Thromb Vasc Bio 2004; 24: 650-657.
3. Glagov S, Weisenberg E, Zarins CK, et al. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987; 316: 1371-1375.
4. Post MJ, de Smet BJ, van der Helm Y, et al. Arterial remodeling after balloon angioplasty or stenting in an atherosclerotic experimental model. Circulation 1997; 96: 996-1003.
5. Walpola PL, Gotlieb Al, Cybulsky MI, et al. Expression of ICAM-1 and VCAM-1 and monocyte adherence in arteries exposed to altered shear stress. Arterioscler Thromb Vasc Biol 1995; 15: 2-10.
6. Chien S, Li S, Shyy YJ. Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension 1998; 31: 162-169.
7. de Kleijn DP, Sluijter JR Smit J, et al. Furin and membrane type-1 metalloprotemase mRNA levels and activation of metalloproteinase-2 are associated with arterial remodeling. FEBS Lett 2001; 501: 37-41.
8. Abbruzzese TA, Guzman RJ, Martin RL, et al. Matrix metalloproteinase inhibition limits arterial enlargements in a rodent arteriovenous fistula model. Surgery 1998; 124: 328-335.
9. Tohda G, Oida K, Okada Y, et al. Expression of thrombomodulin in atherosclerotic lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1998; 18: 1861-1869.
10. Huang HC, Shi GY, Jiang SJ, et al. Thrombomodulin-mediated cell adhesion. J Biol Chem 2003; 278: 46750-46759.
11. Conway EM, Van de Wouwer M, Pollefeyt S, et al. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kB and mitogen-activated protein kinase pathways. J Exp Med 2002; 196: 565-577.
12. Li YH, Liu SL, Shi GY, et al. Thrombomodulin plays an important role in arterial remodeling and neointima formation in mouse carotid ligation model. Thromb Haemost 2006; 95: 128-133.
13. Rockman HA, Knowlton KU, Ross J Jr, et al. In vivo murine cardiac hypertrophy: a novel model to identify genetic signaling mechanisms that activate an adaptive physiological response. Circulation 1993; 87 (Suppl VII): 14-21.
14. Chen HH, Wang DL. Nitric oxide inhibits matrix metalloproteinase-2 expression via the induction of activating transcription factor 3 in endothelial cells. Mol Pharmacol 2004; 65: 1130-1140.
15. Ni CW, Hsieh HJ, Chao YJ, et al. Shear flow attenuates serum-induced STAT3 activation in endothelial cells. J Biol Chem 2003; 278: 19702-19708.
16. Reddy AK, Taffet GE, Li YH, et al. Pulsed Doppler signal processing for use in mice: applications. IEEE Trans Biomed Eng 2005; 52: 1771-1783.
17. Takada Y, Shinkai E Kondo S, et al. Fluid shear stress increases the expression of thrombomodulin by cultured human endothelial cells. Biochem Biophys Acta 1994; 205: 1345-1352.
18. Malek AM, Jackman RW, Rosenberg RD, et al. Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress. Circ Res 1994; 74: 852-860.
19. Greve JM, Les AS, Tang BT, et al. Allometric scaling of wall shear stress from mouse to man: quantification using cine phase-contrast MRI and computational fluid dynamics. Am J Physiol Heart Circ Physiol 2006; 291: H1700-1708.
20. Dardik A, Yamashita A, Aziz E et al. Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1 alpha. J Vasc Surg 2005; 41: 321-331.
21. Palumbo R, Gaetano C, Antonini A, et al. Different effect of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration. Arterioscler Thromb Vasc Biol 2002; 223: 405-411.
22. Ma SF Garcia JG, Reuning U, et al. Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin receptor in cultured bovine smooth muscle cells. J Lab Clin Med 1997; 129: 611-619.
23. Li YH, Chen CH, Yeh PS, et al. Functional mutation in the promoter region of thrombomodulin gene in relation to carotid atherosclerosis. Atherosclerosis 2001; 154:713-719.
24. Laszik ZG, Zhou XJ, Ferrell GL, et al. Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis. Am J Pathol 2001; 159: 797 802.
25. Parmentier EM, Morton WA, Petschek HE. Platelet aggregate formation in a region of separated blood flow. J Biochem Eng 1981; 20: 2012-2021.
26. Corson MA, James NL, Latta SE, et al. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res 1996; 79: 984-991.
27. Irace C, Cortese C, Fiaschi E, et al. Wall shear stress is associated with intima-media thickness and carotid atherosclerosis in subjects at low coronary heart disease risk. Stroke 2004; 35: 464-468.