HIV envelope protein gp120-triggered CD4+ T-cell adhesion to vascular endothelium is regulated via CD4 and CXCR4 receptors

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1772, Issue 5, 2007, Pages 549-555

  Takano, Yoshio ^a   Shimokado, Kentaro ^a   Hata, Yuiro ^a   Yoshida, Masayuki ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Adhesion Molecules; Endothelial cells; Inflammation; Statin; T cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CD4 ANTIGEN; CELL SURFACE RECEPTOR; CHEMOKINE RECEPTOR CXCR4; FLUINDOSTATIN; GLYCOPROTEIN GP 120; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SMALL INTERFERING RNA; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARDIOVASCULAR DISEASE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERCHOLESTEROLEMIA; INFLAMMATION; LEUKEMIA CELL LINE; LEUKOCYTE ADHERENCE; NONHUMAN; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VIRUS ENVELOPE; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIBODIES; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELLS, CULTURED; CHEMOKINES, CXC; ENDOTHELIUM, VASCULAR; FATTY ACIDS, MONOUNSATURATED; HIV ENVELOPE PROTEIN GP120; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; LYMPHOCYTE ACTIVATION; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; RECEPTORS, CXCR4;

EID: 34247117723     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2007.01.010     Document Type: Article

References (31)

1. Wang J., Harada A., Matsushita S., Matsumi S., Zhang Y., Shioda T., Nagai Y., and Matsushima K. IL-4 and a glucocorticoid up-regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV-1 replication. J. Leukocyte Biol. 64 (1998) 642-649
2. Jourdan P., Vendrell J.P., Huguet M.F., Segondy M., Bousquet J., Pene J., and Yssel H. Cytokines and cell surface molecules independently induce CXCR4 expression on CD4+ CCR7+ human memory T cells. J. Immunol. 165 (2000) 716-724
3. Lapham C.K., Ouyang J., Chandrasekhar B., Nguyen N.Y., Dimitrov D.S., and Golding H. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science 274 (1996) 602-605
4. Cohen J. Investigators detail HIV's fatal handshake. Science 274 (1996) 502
5. Fernandez E.J., and Lolis E. Structural studies of chemokines that inhibit HIV-1 entry. Antivir. Chem. Chemother. 1 (2001) 43-49
6. Wang J., Marschner S., and Finkel T.H. CXCR4 engagement is required for HIV-1-induced L-selectin shedding. Blood 103 (2004) 1218-1221
7. Nagasawa T., Hirota S., Tachibana K., Takakura N., Nishikawa S., Kitamura Y., Yoshida N., Kikutani H., and Kishimoto T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382 (1996) 635-638
8. Ma Q., Jones D., Borghesani P.R., Segal R.A., Nagasawa T., Kishimoto T., Bronson R.T., and Springer T.A. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 9448-9453
9. Zou Y.R., Kottmann A.H., Kuroda M., Taniuchi I., and Littman D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393 (1998) 595-599
10. Tashiro K., Tada H., Heilker R., Shirozu M., Nakano T., and Honjo T. Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science 261 (1993) 600-603
11. Popik W., Hesselgesser J.E., and Pitha P.M. Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. J. Virol. 72 (1998) 6406-6413
12. Stamler J., Vaccaro O., Neaton J.D., and Wentworth D. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 16 (1993) 434-444
13. van Wissen S., Trip M.D., Smilde T.J., de Graaf J., Stalenhoef A.F., and Kastelein J.J. Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy. Atherosclerosis 165 (2002) 361-366
14. Yoshida M., Westlin W.F., Wang N., Ingber D.E., Rosenzweig A., Resnick N., and Gimbrone Jr. M.A. Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton. J. Cell Biol. 133 (1996) 445-455
15. Yoshida M., Szente B.E., Kiely J.M., Rosenzweig A., and Gimbrone Jr. M.A. Phosphorylation of the cytoplasmic domain of E-selectin is regulated during leukocyte-endothelial adhesion. J. Immunol. 161 (1998) 933-941
16. Benzair A.B., Hirsch I., and Chermann J.C. Binding of human immunodeficiency virus type-1 (HIV-1) to partially purified membrane vesicles of lymphoblastoid cell line CEM. J. Virol. Methods 45 (1993) 319-330
17. Luscinskas F.W., Kansas G.S., Ding H., Pizcueta P., Schleiffenbaum B.E., Tedder T.F., and Gimbrone Jr. M.A. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J. Cell Biol. 125 (1994) 1417-1427
18. Yoshida M., Sawada T., Ishii H., Gerszten R.E., Rosenzweig A., Gimbrone Jr. M.A., Yasukochi Y., and Numano F. Hmg-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase-dependent mechanism. Arterioscler., Thromb., Vasc. Biol. 21 (2001) 1165-1171
19. Kawakami A., Tanaka A., Nakajima K., Shimokado K., and Yoshida M. Atorvastatin attenuates remnant lipoprotein-induced monocyte adhesion to vascular endothelium under flow conditions. Circ. Res. 91 (2002) 263-271
20. Novina C.D., Murray M.F., Dykxhoorn D.M., Beresford P.J., Riess J., Lee S.K., Collman R.G., Lieberman J., Shankar P., and Sharp P.A. siRNA-directed inhibition of HIV-1 infection. Nat. Med. 8 (2002) 681-686
21. Wojciak-Stothard B., Williams L., and Ridley A.J. Monocyte adhesion and spreading on human endothelial cells is dependent on Rho-regulated receptor clustering. J. Cell Biol. 145 (1999) 1293-1307
22. Ishibashi T., Sakamoto T., Ohkawara H., Nagata K., Sugimoto K., Sakurada S., Sugimoto N., Watanabe A., Yokoyama K., Sakamoto N., Kurabayashi M., Takuwa Y., and Maruyama Y. Integral role of RhoA activation in monocyte adhesion-triggered tissue factor expression in endothelial cells. Arterioscler., Thromb., Vasc. Biol. 23 (2003) 681-687
23. Worthylake R.A., Lemoine S., Watson J.M., and Burridge K. RhoA is required for monocyte tail retraction during transendothelial migration. J. Cell Biol. 154 (2001) 147-160
24. Borkow G., Vijayabaskar V., Lara H.H., Kalinkovich A., and Lapidot A. Structure-activity relationship of neomycin, paromomycin, and neamine-arginine conjugates, targeting HIV-1 gp120-CXCR4 binding step. Antiviral Res. 60 (2003) 181-192
25. Roland J., Murphy B.J., Ahr B., Robert-Hebmann V., Delauzun V., Nye K.E., Devaux C., and Biard-Piechaczyk M. Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling. Blood 101 (2003) 399-406
26. Suzuki Y., Rahman M., and Mitsuya H. Diverse transcriptional response of CD4(+) T cells to stromal cell-derived factor (SDF)-1: cell survival promotion and priming effects of SDF-1 on CD4(+) T cells. J. Immunol. 167 (2001) 3064-3073
27. Ashida N., Arai H., Yamasaki M., and Kita T. Distinct signaling pathways for MCP-1-dependent integrin activation and chemotaxis. J. Biol. Chem. 276 (2001) 16555-16560
28. Brainard D.M., Tharp W.G., Granado E., Miller N., Trocha A.K., Ren X.H., Conrad B., Terwilliger E.F., Wyatt R., Walker B.D., and Poznansky M.C. Migration of antigen-specific T cells away from CXCR4-binding human immunodeficiency virus type 1 gp120. J. Virol. 78 (2004) 5184-5193
29. Amara A., Gall S.L., Schwartz O., Salamero J., Montes M., Loetscher P., Baggiolini M., Virelizier J.L., and Arenzana-Seisdedos F. HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J. Exp. Med. 186 (1997) 139-146
30. Tilton B., Ho L., Oberlin E., Loetscher P., Baleux F., Clark-Lewis I., and Thelen M. Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. J. Exp. Med. 192 (2000) 313-324
31. Bardi G., Sengupta R., Khan M.Z., Patel J.P., and Meucci O. Human immunodeficiency virus gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization. J. Neurovirol. 12 (2006) 211-218