Perineurioma: A distinctive and underrecognized peripheral nerve sheath neoplasm

Archives of Pathology and Laboratory Medicine

Volumn 131, Issue 4, 2007, Pages 625-636

  Macarenco, Ricardo S ^a,c,d   Ellinger, Fred ^b   Oliveira, Andre M ^c  

^a CIPAX   (Brazil)

^b FACULDADE DE MEDICINA DE MARÍLIA   (Brazil)

^c MAYO CLINIC   (United States)

^d NONE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CLAUDIN 1; EPITHELIAL MEMBRANE ANTIGEN; GLUCOSE TRANSPORTER 1; PROTEIN S 100;

CELL ULTRASTRUCTURE; CLINICAL FEATURE; CYTOGENETICS; DIFFERENTIAL DIAGNOSIS; ELECTRON MICROSCOPY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOLECULAR GENETICS; NERVE SHEATH TUMOR; NERVE TUMOR; REVIEW;

DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; MICROSCOPY, ELECTRON; NERVE SHEATH NEOPLASMS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 34147163405     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: None     Document Type: Review

References (74)

1. Lazarus SS, Trombetta LD. Ultrastructural identification of a benign perineurial cell tumor. Cancer. 1978;41:1823-1829.
2. Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB. Intraneural perineurioma: a clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol. 1995;103:696-704.
3. Mentzel T, Dei Tos AP, Fletcher CD. Perineurioma (storiform perineurial fibroma): clinico-pathological analysis of four cases. Histopathology. 1994;25:261-267.
4. Shanthaveerappa TR, Bourne GH. Perineural epithelium: a new concept of its role in the integrity of the peripheral nervous system. Science. 1966;154:1464-1467.
5. Balarezo FS, Muller RC, Weiss RG, Brown T, Knibbs D, Joshi VV. Soft tissue perineuriomas in children: report of three cases and review of the literature. Pediatr Dev Pathol. 2003;6:137-141.
6. Fetsch JF, Miettinen M. Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults. Am J Surg Pathol. 1997;21:1433-1442.
7. Brock JE, Perez-Atayde AR, Kozakewich HP, Richkind KE, Fletcher JA, Vargas SO. Cytogenetic aberrations in perineurioma: variation with subtype. Am J Surg Pathol. 2005;29:1164-1169.
8. Hirose T, Scheithauer BW. "Sclerosing" perineurioma: a tumor variant? Int J Surg Pathol. 1999;7:133-140.
9. Scheithauer BW, Woodruff JM, Erlandson RA. Tumors of the Peripheral Nervous System. Washington, DC: Armed Forces Institute of Pathology; 1999. Atlas of Tumor Pathology, 3rd series, fascicle 24.
10. Giannini C, Scheithauer BW, Jenkins RB, et al. Soft-tissue perineurioma: evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol. 1997;21:164-173.
11. Graadt van Roggen JF, McMenamin ME, Belchis DA, Nielsen GP, Rosenberg AE, Fletcher CD. Reticular perineurioma: a distinctive variant of soft tissue perineurioma. Am J Surg Pathol. 2001;25:485-493.
12. Michal M. Extraneural retiform perineuriomas: a report of four cases. Pathol Res Pract. 1999;195:759-763.
13. Robson AM, Calonje E. Cutaneous perineurioma: a poorly recognized tumour often misdiagnosed as epithelioid histiocytoma. Histopathology. 2000;37:332-339.
14. Hornick JL, Fletcher CD. Soft tissue perineurioma: clinicopathologic analysis of 81 cases including those with atypical histologic features. Am J Surg Pathol. 2005;29:845-858.
15. Giannini C, Scheithauer BW, Steinberg J, Cosgrove TJ. Intraventricular perineurioma: case report. Neurosurgery. 1998;43:1478-1481.
16. Hornick JL, Fletcher CD. Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol. 2005;29:859-865.
17. Val-Bernal JF, Hernando M, Garijo MF, Villa P. Renal perineurioma in childhood. Gen Diagn Pathol. 1997;143:75-81.
18. Ortonne JP, Verrando P, Pautrat G, Darmon M. Lamellar cells of sensory receptors and perineural cells of nerve endings of pig skin contain cytokeratins. Virchows Arch A Pathol Anat Histopathol. 1987;410:547-552.
19. Meis JM, Ordonez NG, Bruner JM. Meningiomas: an immunohistochemical study of 50 cases. Arch Pathol Lab Med. 1986;110:934-937.
20. Zamecnik M, Michal M, Baumruk L, Mukensnabl P. Dermatofibrosarcoma protuberans with EMa+ cells: report of a case suggesting perineurial cell differentiation. Pathol Res Pract. 2002;198:767-774.
21. Sirvent N, Maire G, Pedeutour F. Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer. 2003;37:1-19.
22. Ohno T, Park P, Akai M, et al. Ultrastructural study of a perineurioma. Ultrastruct Pathol. 1988;12:495-504.
23. Gelli MC, Pasquinelli G, Martinelli G, Gardini G. Cutaneousmeningioma: histochemical, immunohistochemical and ultrastructural investigation. Histopathology. 1993;23:576-578.
24. Peltonen J, Jaakkola S, Virtanen I, Pelliniemi L. Perineurial cells in culture: an immunocytochemical and electron microscopic study. Lab Invest. 1987;57:480-488.
25. Mertens F, Fletcher CD, Antonescu CR, et al. Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. Lab Invest. 2005;85:408-415.
26. Gengler C, Guillou L. Solitary fibrous tumour and haemangiopericytoma: evolution of a concept. Histopathology. 2006;48:63-74.
27. Feany MB, Anthony DC, Fletcher CD. Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge. Histopathology. 1998;32:405-410.
28. Zamecnik M, Michal M. Perineurial cell differentiation in neurofibromas: report of eight cases including a case with composite perineurioma-neurofibroma features. Pathol Res Pract. 2001;197:537-544.
29. Michal M, Kazakov DV, Belousova I, Bisceglia M, Zamecnik M, Mukensnabl P. A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. Virchows Arch. 2004;445:347-353.
30. Kazakov DV, Pitha J, Sima R, et al. Hybrid peripheral nerve sheath tumors: schwannoma-perineurioma and neurofibroma-perineurioma: a report of three cases in extradigital locations. Ann Diagn Pathol. 2005;9:16-23.
31. Bundock EA, Fletcher CDM. Nerve sheath tumors with hybrid features of perineurioma and schwannoma [abstract]. Mod Pathol. 2004;17:12A.
32. Val-Bernal JF, Garijo MF, Val D. Response to "Intratumoral fat in neurofibroma." Am J Dermatopathol. 2003;25:174-175.
33. Miettinen M. Nerve sheath tumors. In: Miettinen M, ed. Diagnostic Soft Tissue Pathology. Philadelphia, Pa: Churchill Livingstone; 2003:343-378.
34. Pulitzer DR, Martin PC, Reed RJ. Fibroma of tendon sheath: a clinicopathologic study of 32 cases. Am J Surg Pathol. 1989;13:472-479.
35. Ushigome S, Takakuwa T, Hyuga M, Tadokoro M, Shinagawa T. Perineurial cell tumor and the significance of the perineurial cells in neurofibroma. Acts Pathol Jpn. 1986;36:973-987.
36. Mentzel T, Kutzner H. Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues. Virchows Arch. 2005;447:677-682.
37. Shelekhova K, Kazakov DV, Michal M. Infiltrating retiform perineurioma: a case report. Ann Diagn Pathol. 2005;9:293-294.
38. de La Jarte-Thirouard AS, Jacquier I, de Saint-Maur PP. Intraneural reticular perineurioma of the neck. Ann Diagn Pathol. 2003;7:120-123.
39. Kilpatrick SE, Hitchcock MG, Kraus MD, Calonje E, Fletcher CD. Mixed tumors and myoepitheliomas of soft tissue: a clinicopathologic study of 19 cases with a unifying concept. Am J Surg Pathol. 1997;21:13-22.
40. Hirose T, Scheithauer BW, Sano T. Perineurial malignant peripheral nerve sheath tumor (MPNST): a clinicopathologic, immunohistochemical, and ultrastructural study of seven cases. Am J Surg Pathol. 1998;22:1368-1378.
41. Graadt van Roggen JF, Hogendoorn PC, Fletcher CD. Myxoid tumours of soft tissue. Histopathology. 1999;35:291-312.
42. Lasota J, Jasinski M, biec-Rychter M, Szadowska A, Limon J, Miettinen M. Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma. Mod Pathol. 1998;11:626-633.
43. Huguet P, de la TJ, Pallares J, et al. Intraosseous intraneural perineurioma: report of a case with morphological, immunohistochemical and FISH study. Med Oral. 2004;9:64-68.
44. Damm DD, White DK, Merrell JD. Intraneural perineurioma not restricted to major nerves. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96:192-196.
45. Chang Y, Horoupian DS, Jordan J, Steinberg G. Localized hypertrophic mononeuropathy of the trigeminal nerve. Arch Pathol Lab Med. 1993;117:170-176.
46. Neary D, Ochoa J. Localized hypertrophic neuropathy, intraneural tumour, or chronic nerve entrapment? [letter]. Lancet. 1975;1:632-633.
47. Mitsumoto H, Wilbourn AJ, Goren H. Perineurioma as the cause of localized hypertrophic neuropathy. Muscle Nerve. 1980;3:403-412.
48. Bilbao JM, Khoury NJ, Hudson AR, Briggs SJ. Perineurioma (localized hypertrophic neuropathy). Arch Pathol Lab Med. 1984;108:557-560.
49. Lasota J, Fetsch JF, Wozniak A, Wasag B, Sciot R, Miettinen M. The neurofibromatosis type 2 gene is mutated in perineurial cell tumors: a molecular genetic study of eight cases. Am J Pathol. 2001;158:1223-1229.
50. Diaz-Flores L, Alvarez-Arguelles H, Madrid JF, Varela H, Gonzalez MP, Gutierrez R. Perineurial cell tumor (perineurioma) with granular cells. J Cutan Pathol. 1997;24:575-579.
51. Rank JP, Rostad SW. Perineurioma with ossification: a case report with immunohistochemical and ultrastructural studies. Arch Pathol Lab Med. 1998;122:366-370.
52. Zamecnik M. Perineurioma with adipocytes (lipomatous perineurioma). Am J Dermatopathol. 2003;25:171-173.
53. Burgues O, Monteagudo C, Noguera R, Revert A, Molina I, Llombart-Bosch A. Cutaneous sclerosing Pacinian-like perineurioma. Histopathology. 2001;39:498-502.
54. Pinkus GS, Kurtin PJ. Epithelial membrane antigen-a diagnostic discriminant in surgical pathology: immunohistochemical profile in epithelial, mesenchymal, and hematopoietic neoplasms using paraffin sections and monoclonal antibodies. Hum Pathol. 1985;16:929-940.
55. Scheithauer BW, Giannini C, Woodruff JM. Perineurioma. In: Kleihues P, Cavenee WK, eds. Pathology and Genetics of Tumours of the Nervous System. Lyon, France: IARC Press; 2000:169-171. World Health Organization Classification of Tumours.
56. Kahn DG, Duckett T, Bhuta SM. Perineurioma of the kidney: report of a case with histologic, immunohistochemical, and ultrastructural studies. Arch Pathol Lab Med 1993;117:654-657.
57. Smith ME, Awasthi R, O'Shaughnessy S, Fisher C. Evaluation of perineurial differentiation in epithelioid sarcoma. Histopathology. 2005;47:575-581.
58. Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S. Claudin-1 and-2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol. 1998;141:1539-1550.
59. Gonzalez-Mariscal L, Betanzos A, Nava P, Jaramillo BE. Tight junction proteins. Prog Biophys Mol Biol. 2003;81:1-44.
60. Rangel LB, Agarwal R, D'Souza T, et al. Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Clin Cancer Res. 2003;9:2567-2575.
61. Billings SD, Walsh SV, Fisher C, Nusrat A, Weiss SW, Folpe AL. Aberrant expression of tight junction-related proteins ZO-I, claudin-1 and occludin in synovial sarcoma: an immunohistochemical study with ultrastructural correlation. Mod Pathol. 2004;17:141-149.
62. Folpe AL, Billings SD, McKenney JK, Walsh SV, Nusrat A, Weiss SW. Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics. Am J Surg Pathol. 2002;26:1620-1626.
63. Erlandson RA. The enigmatic perineurial cell and its participation in tumors and in tumorlike entities. Ultrastruct Pathol. 1991;15:335-351.
64. Mueckler M. Facilitative glucose transporters, Eur J Biochem. 1994;219:713-725.
65. Younes M, Lechago LV, Somoano JR, Mosharaf M, Lechago J. Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers. Cancer Res. 1996;56:1164-1167.
66. Hirose T, Tani T, Shimada T, Ishizawa K, Shimada S, Sano T. Immunohistochemical demonstration of EMA/Glut1-positive perineurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors. Mod Pathol. 2003;16:293-298.
67. Mertens F, Dal CP, De Wever I, et al. Cytogenetic characterization of peripheral nerve sheath tumours: a report of the CHAMP study group. J Pathol. 2000;190:31-38.
68. Mott RT, Goodman BK, Burchette JL, Cummings TJ. Loss of chromosome 13 in a case of soft tissue perineurioma. Clin Neuropathol. 2005;24:69-76.
69. Hirose T, Sumitomo M, Kudo E, et al. Malignant peripheral nerve sheath tumor (MPNST) showing perineurial cell differentiation. Am J Surg Pathol. 1989;13:613-620.
70. Karaki S, Mochida J, Lee YH, Nishimura K, Tsutsumi Y. Low-grade malignant perineurioma of the paravertebral column, transforming into a high-grade malignancy. Pathol Int. 1999;49:820-825.
71. Rosenberg AS, Langee CL, Stevens GL, Morgan MB. Malignant peripheral nerve sheath tumor with perineurial differentiation: "malignant perineurioma." J Cutan Pathol. 2002;29:362-367.
72. Suster D, Plaza JA, Shen R. Low-grade malignant perineurioma (perineurial sarcoma) of soft tissue: a potential diagnostic pitfall on fine needle aspiration. Ann Diagn Pathol. 2005;9:197-201.
73. Zamecnik M, Koys F, Gomolcak P. Atypical cellular perineurioma. Histopathology. 2002;40:296-299.
74. Gruen JP, Mitchell W, Kline DG. Resection and graft repair for localized hypertrophic neuropathy. Neurosurgery. 1998;43:78-83.