Immunohistochemical demonstration of EMA/Glut1-positive perineurial cells and CD34-positive fibroblastic cells in peripheral nerve sheath tumors

Modern Pathology

Volumn 16, Issue 4, 2003, Pages 293-298

  Hirose, Takanori ^a   Tani, Takayuki ^a   Shimada, Tetsuya ^a   Ishizawa, Keisuke ^a   Shimada, Shio ^a   Sano, Toshiaki ^b  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

CD34; EMA; Endoneurial fibroblast; Glut1; Immunohistochemistry; Perineurial cell; Peripheral nerve sheath tumor

Indexed keywords

CD34 ANTIGEN; EPITHELIAL MEMBRANE ANTIGEN; GLUCOSE TRANSPORTER 1; PROTEIN S 100; TUMOR MARKER;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENDONEURIUM; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERMETHOD COMPARISON; NERVE SHEATH TUMOR; NERVE TUMOR; NEURILEMOMA; NEUROFIBROMA; NEUROMA; PERINEURIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHWANN CELL; SIGNAL PROCESSING;

ANTIGENS, CD34; E2F6 TRANSCRIPTION FACTOR; FIBROBLASTS; GLUCOSE TRANSPORTER TYPE 1; HUMANS; IMMUNOHISTOCHEMISTRY; MONOSACCHARIDE TRANSPORT PROTEINS; NERVE SHEATH NEOPLASMS; PERIPHERAL NERVES; REPRESSOR PROTEINS; S100 PROTEINS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0037395235     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.MP.0000062654.83617.B7     Document Type: Article

References (26)

1. Ortiz-Hidalgo C, Weller RO. Peripheral nervous system. In: Sternberg SS, editor. Histology for pathologists. 2nd ed. Philadelphia, PA: Lippincott-Raven; 1997. p. 285-311.
2. Erlandson RA. Diagnostic transmission electron microscopy of tumors with clinicopathological, immunohistochemical, and cytogenetic correlations. New York: Raven Press; 1994.
3. Perentes E, Nakagawa Y, Ross GW, Stanton C, Rubinstein LJ. Expression of epithelial membrane antigen in perineurial cells and their derivatives. An immunohistochemical study with multiple markers. Acta Neuropathol (Berl) 1987;75:160-5.
4. Fogt F, Capodieci P, Loda M. Assessment of perineurial invasion by GLUT-1 immunohistochemistry. Appl Immunohistochem 1995;3:194-7.
5. Erlandson RA, Woodruff JM. Peripheral nerve sheath tumors: an electron microscopic study of 43 cases. Cancer 1982;49:273-87.
6. Scheithauer BW, Woodruff JM, Erlandson RA. Tumors of the peripheral nervous system. Atlas of tumor pathology. 3rd series. Fascicle 24. Washington, D.C.: Armed Forces Institute of Pathology; 1999.
7. Giannini C, Scheithauer BW, Jenkins RB, Erlandson RA, Perry A, Borell TJ, et al. Soft-tissue perineurioma. Evidence for an abnormality of chromosome 22, criteria for diagnosis, and review of the literature. Am J Surg Pathol 1997;21:164-73.
8. Hirose T, Sano T, Hizawa K. Ultrastructural localization of S-100 protein in neurofibromas. Acta Neuropathol (Berl) 1986;69:103-10.
9. Erlandson RA. The enigmatic perineurial cells and its participation in tumors and in tumorlike entities. Ultrastruct Pathol 1991;15:335-51.
10. Weiss SW, Nickoloff BJ. CD-34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol 1993;17:1039-45.
11. Weiss SW, Goldblum JR. Enzinger and Weiss's soft tissue tumors. 4th ed. St. Louis: Mosby; 2001.
12. Hirose T, Scheithauer BW. "Sclerosing" perineurioma: a tumor variant? Int J Surg Pathol 1999;7:133-40.
13. Hirose T, Scheithauer BW, Sano T. Perineurial malignant peripheral nerve sheath tumor (MPNST). A clinicopathologic, immunohistochemical, and ultrastructural study of seven cases. Am J Surg Pathol 1998;22:1368-78.
14. Sanno N, Teramoto A, Sugiyama M, Itoh Y, Osamura RY. Application of catalyzed signal amplification in immunodetection of gonadotropin subunits in clinically nonfunctioning pituitary adenomas. Am J Clin Pathol 1996;106:16-21.
15. Nakajima T, Kameya T, Watanabe S, Hirota T, Sato Y, Shimosato Y. An immunoperoxidase study of S-100 protein distribution in normal and neoplastic tissues. Am J Surg Pathol 1982;6:715-27.
16. Theaker JM, Gatter KC, Puddle J. Epithelial membrane antigen expression by the perineurium of peripheral nerve and in peripheral nerve tumours. Histopathology 1988;13:171-9.
17. Ariza A, Bilbao JM, Rosai J. Immunohistochemical detection of epithelial membrane antigen in normal perineurial cells and perineurioma. Am J Surg Pathol 1988;12:678-83.
18. Fetsch J, Miettinen M. Sclerosing perineurioma. A clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults. Am J Surg Pathol 1997;21:1433-42.
19. Van Roggen JFG, McMenamin ME, Belchis DA, Nielsen GP, Rosenberg AE, Fletcher CDM. Reticular perineurioma. A distinctive variant of soft tissue perineurioma. Am J Surg Pathol 2001;25:485-93.
20. Emory TS, Scheithauer BW, Hirose T, Wood M, Onofrio BM, Jenkins RB. Intraneural perineurioma. A clonal neoplasm associated with abnormalities of chromosome 22. Am J Clin Pathol 1995;103:696-704.
21. Mueckler M. Facilitative glucose transporters. Eur J Biochem 1994;219:713-25.
22. Kalir T, Wang BY, Goldfischer M, Haber RS, Reder I, Demopoulos R, et al. Immunohistochemical staining of GLUT1 in benign, borderline, and malignant ovarian epithelia. Cancer 2002;94:1078-82.
23. Kakita Y, Oshiro K, O'Brian DS, Puri P. Selective demonstration of mural nerves in ganglionic and aganglionic colon by immunohistochemistry for glucose transporter-1. Prominent extrinsic nerve pattern staining in Hirshsprung disease. Arch Pathol Lab Med 2000;124:1314-9.
24. Herrera GA, de Moraes HP. Neurogenic sarcomas in patients with neurofibromatosis (von Recklinghausen's disease). Light, electron microscopy and immunohistochemical study. Virchows Arch (Pathol Anat) 1984;403:361-76.
25. Fisher C, Carter RL, Ramachandra S, Thomas DM. Peripheral nerve sheath differentiation in malignant soft tissue tumours: an ultrastructural and immunohistochemical study. Histopathology 1992;20:115-25.
26. Hirose T, Hasegawa T, Kudo E, Seki K, Sano T, Hizawa K. Malignant peripheral nerve sheath tumors: an immunohistochemical study in relation to ultrastructural features. Hum Pathol 1992;23:865-70.