Novel short peptides isolated from phage display library inhibit vascular endothelial growth factor activity

Molecular Biotechnology

Volumn 35, Issue 1, 2007, Pages 51-63

  Erdag, Berrin ^a   Balcioglu, Koray B ^a   Kumbasar, Asli ^a   Celikbicak, Omur ^b   Zeder Lutz, Gabrielle ^c   Altschuh, Danièle ^c   Salih, Bekir ^b   Baysal, Kemal ^a  

^a Research Institute for Genetic Engineering and Biotechnology   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Angiogenesis; HUVEC; Peptide; Phage display; Vascular endothelial growth factor

Indexed keywords

ANGIOGENESIS; ANTITUMOR THERAPY; PHAGE DISPLAY; VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF);

DESORPTION; ENZYME INHIBITION; GROWTH KINETICS; ONCOLOGY; STOICHIOMETRY; SYNTHESIS (CHEMICAL);

PEPTIDES;

ANGIOGENESIS INHIBITOR; PEPTIDE LIBRARY; SYNTHETIC PEPTIDE; TRYPTOPHYLHISTIDYLLEUCYLPROLYLPHENYLALANYLLYSYLCYSTEINE; TRYPTOPHYLHISTIDYLLYSYLPROLYLPHENYLALANYLARGINYLPHENYLALANINE; UNCLASSIFIED DRUG; VASCULOTROPIN 165; VASCULOTROPIN INHIBITOR;

ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; CONCENTRATION RESPONSE; DRUG PROTEIN BINDING; DRUG SCREENING; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PEPTIDE SYNTHESIS; PHAGE DISPLAY; PROTEIN BINDING; PROTEIN ISOLATION; RECEPTOR BINDING; STOICHIOMETRY; VASCULAR ENDOTHELIUM;

AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; BIOREACTORS; BIOTECHNOLOGY; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN BINDING; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34147125419     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:35:1:51     Document Type: Article

References (29)

1. Folkman, J. (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27-31.
2. Carmeliet, P. (2003) Angiogenesis in health and disease Nature. Med. 9, 653-660.
3. Carmeliet, P., Ferriera, V., Breier, G., et al. (1996) Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435-439.
4. Tammela, T., Enholm, B., Alitalo, K., and Paavonen, K. (2005) The biology of vascular endothelial growth factors. Cardiovasc. Res. 65, 550-563.
5. De-Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. (1992) The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255, 989-991.
6. Ferrara, N., Gerber, H. P., and LeCouter, J. (2003) The biology of VEGF and its receptors. Nat. Med. 9, 669-676.
7. Hicklin, D. J., Witte, L., Zhu, Z., et al. (2001) Monoclonal antibody strategies to block angiogenesis. DDT 6, 517-528.
8. Kim, K. J., Li, B., Winer, J., et al. (1993) Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumor growth in vivo. Nature 362, 841-844.
9. Lander, R. C., Sato, A. K., Gorzelany, J., and Souza, M. (2004) Phage display derived peptides as therapeutic alternatives to antibodies. DDT 9, 525-529.
10. Bikfalvi, A. and Bicknell, R. (2002) Recent advances in angiogenesis, anti-angiogenesis and vascular targeting. Trends Pharmacol. Sci. 23, 576-582.
11. Smith, G. P. and Scott, J. K. (1993) Libraries of peptides and proteins displayed on Filamentous phage. Methods Enzymol. 217, 228-257.
12. Fairbrother, W. F., Christinger, H. S., Cochran, A. G., et al. (1998) Novel peptides selected to bind Vascular Endothelial growth factor target the Receptor binding site. Biochemistry 37, 17,754-17,764.
13. Asai, T., Magatsuka, M., Kuromi, K., et al. (2002) Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels. FEBS Lett. 510, 206-210.
14. Binetruy-Tournaire, R., Demongel, C., Mulavaud, B., et al. (2000) Identification of a peptide blocking vascular endothelial growth factor (VEGF) mediated angiogenesis. EMBO J. 19, 1527-1533.
15. Hetian, L., Ping, A., Shumei, S., et al. (2002) A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor. J. Biol. Chem. 277, 43,137-43,14.
16. Piossek, C., Scheider-Mergener, J., Schirer, M., Vakalopoulou, E., Germeroth, L., and Thierauch, K. H. (1999) Vascular endothelial growth factor (VEGF) receptor II-derived peptides inhibit VEGF. J. Biol. Chem. 274, 5612-5619.
17. Nakamura, T., Takasugi, H., Aizawa, T., et al. (2005) Peptide mimics of epidermal growth factor with antagonistic activity. J. Biotechnol. 116, 211-219.
18. Scott, J. K and Smith, G. P.(1990) Searching for peptide ligands with an epitope library. Science 249, 389-395.
19. Jaffe, E. A., Nachmann, R. L., Becker, C. G., and Minick, C. R. (1973) Culture of human endothelial cells from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52, 2745- 2756.
20. Maciag, T., Cerundolo, J., Ilsley, S., Kelley, P. R., and Forand, R. (1979) An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization. Proc. Natl. Acad. Sci. USA 76, 5674-5678.
21. Rousch, M., Lutgerink, J. T., Coote, J., de Bruine, A., Arends, J. W., and Hoogenboom, H. R. (1998) Somatostatin displayed on filamentous phage as a receptor-specific. Br. J. Pharmacol. 125, 5-16.
22. Hoogenboom, H. R., Lutgerink, J. T., Pelsers, M. M., et al. (1999) Selection-dominant and nonaccessible epitopes on cell-surface receptors revealed by cellpanning with a large phage antibody library. Eur. J. Biochem. 260, 774-784.
23. Ueda, Y., Yamagishi, T., Samata, K., et al. (2003) A novel low molecular weight antagonist of vascular endothelial growth factor receptor binding: VGA 1155. Mol. Cancer Ther. 2, 1105-1111.
24. Karlsson, R., Michaelsson, A., and Mattsson, L. (1991) Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. J. Immunol. Methods 145, 229-240.
25. Monk, B. J., Choi, D. C., Pugmire, G., and Burger, R. A. (2005) Activity of bevacizumab (rhuMAB VEGF) in advanced refractory epithelial ovarian cancer. Gynecologic Oncology 96, 902-905.
26. Lien, S. and Lowman, H. B. (2003) Therapeutic peptides. Trends Biotechnol. 21, 556-562.
27. An, P., Lei, H., Zhang, J., et al. (2004) Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int. J. Cancer 111, 165-173.
28. Koivunen, E., Arap, W., Valtanen, et al. (1999) Tumor targeting with a selective gelatinase inhibitor Nature Biotechnology 17, 768-774.
29. Kim, M. Y., Byeon, C. W., Hong, K. H., Han, K. H., and Jeong, S. (2005) Inhibition of the angiogenesis by the MCP-1(monocyte chemoattractant protein-1) binding peptide FEBS Lett. 579, 1597-1601.