Cytochrome P450 destruction by benzene metabolites 1,4-benzoquinone and 1,4-hydroquinone and the formation of hydroxyl radicals in minipig liver microsomes

Toxicology in Vitro

Volumn 21, Issue 4, 2007, Pages 566-575

  Kondrová, Eliška ^a,b   Stopka, Pavel ^c   Souček, Pavel ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^c INSTITUTE OF INORGANIC CHEMISTRY   (Czech Republic)

Author keywords

Benzoquinone; Cytochrome P450; Destruction; ESR; Hydroquinone; Hydroxyl radicals; P450

Indexed keywords

1,4 BENZOQUINONE; 1,4 HYDROQUINONE; ANTHRACYCLINE; BENZENE DERIVATIVE; CYTOCHROME P450; DOXORUBICIN; HYDROXYL RADICAL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME DEGRADATION; LIVER MICROSOME; LIVER TOXICITY; MALE; MINIPIG; NONHUMAN; OXIDATIVE STRESS; SPIN TRAPPING;

ALGORITHMS; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BENZENE; BENZOQUINONES; CATECHOLS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DOXORUBICIN; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HYDROQUINONES; HYDROXYL RADICAL; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; NADP; ORCHIECTOMY; OXIDATIVE STRESS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; SWINE, MINIATURE;

EID: 34147116589     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2006.11.002     Document Type: Article

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