Activation of PKC induces rapid morphological plasticity in dendrites of hippocampal neurons via Rac and Rho-dependent mechanisms

European Journal of Neuroscience

Volumn 19, Issue 12, 2004, Pages 3151-3164

  Pilpel, Yair ^a   Segal, Menahem ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Actin cytoskeleton; GTPase; Lamellae; PKC; Tissue culture

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; RAC PROTEIN; RHO FACTOR; TOXIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL CULTURE; CELL STRUCTURE; CONTROLLED STUDY; DENDRITE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HIPPOCAMPUS; LAMELLAR BODY; NONHUMAN; PLASTICITY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SYNAPSE;

ANIMALS; CELLS, CULTURED; DENDRITES; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NEURONAL PLASTICITY; PROTEIN KINASE C; RAC GTP-BINDING PROTEINS; RATS; RHO GTP-BINDING PROTEINS; SYNAPTIC TRANSMISSION; TETRADECANOYLPHORBOL ACETATE; TRANSFECTION;

EID: 3042707289     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0953-816X.2004.03380.x     Document Type: Article

References (29)

1. Altman, A. & Villabalba, M. (2003) Protein kinase C-theta (PKC theta): it's all about location, location, location. Immunol. Rev., 192, 53.
2. Barandier, C., Ming, X.F., Rusconi, S. & Yang, Z. (2003) PKC is required for activation of ROCK by RhoA in human endothelial cells. Biochem. Biophys. Res. Commun., 304, 714-719.
3. Bishop, A.L. & Hall, A. (2000) Rho GTPases and their effector proteins. Biochem. J., 348, 241-255.
4. Bonhoeffer, T. & Yuste, R. (2002) Spine motility: phenomenology, mechanisms, and function. Neuron, 35, 1019-1027.
5. Byrne, J.H. & Kandel, E.R. (1996) Presynaptic facilitation revisited: state and time dependence. J. Neurosci., 16, 425-435.
6. Du, G., Altshuller, Y.M., Kim, Y., Han, J.M., Ryu, S.H., Morris, A.J. & Frohman, M.A. (2000) Dual requirement for Rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling. Mol. Biol. Cell., 11, 4359-4368.
7. Fong, D.K., Rao, A., Crump, F.T. & Craig, A.M. (2002) Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/calmodulin-dependent kinase II. J. Neurosci., 22, 2153-2164.
8. Goldin, M. & Segal, M. (2003) Protein kinase C and ERK involvement in dendritic spine plasticity in cultured rodent hippocampal neurons. Eur. J. Neurosci., 17, 2529-2539.
9. Goldin, M., Segal, M. & Avignone, E. (2001) Functional plasticity triggers formation and pruning of dendritic spines in cultured hippocampal networks. J. Neurosci., 21, 186-193.
10. Heicklen-Klein, A., Aronov, S. & Ginzburg, I. (2000) Tau promoter activity in neuronally differentiated P19 cells. Brain Res., 874, 1-9.
11. Katoh, H., Aoki, J., Yamaguchi, Y., Kitano, Y., Ichikawa, A. & Negishi, M.J. (1998) Constitutively active Galpha12, Galpha13, and Galphaq induce Rho-dependent neurite retraction through different signaling pathways. Biol. Chem., 273, 28700-28707.
12. Liu, W.S. & Heckman, C.A. (1998) The sevenfold way of PKC regulation. Cell Signal., 10, 529-542.
13. Luo, L., Jan, L.Y. & Jan, Y.N. (1997) Rho family GTP-binding proteins in growth cone signaling. Curr. Opin. Neurobiol., 1, 81-86.
14. Matus, A. (2000) Actin-based plasticity in dendritic spines. Science, 290, 754-758.
15. Meyer, G. & Feldman, E.L. (2002) Signaling mechanisms that regulate actin-based motility processes in the nervous system. J. Neurochem., 83, 490-503.
16. Murthy, K.S., Zhou, H., Grider, J.R., Brautigan, D.L., Eto, M. & Makhlouf, G.M. (2003) Differential signaling by muscarinic receptors in smooth muscle: m2-mediated inactivation of MLCK via Gi3, Cdc42/Rac1, and PAK1, and m3-mediated MLC20 phosphorylation via Rho kinase/MYPT1 and PKC/CPI-17 pathways. Biochem. J., 374, 145-155.
17. Naisbitt, S., Kim, E., Tu, J.C., Xiao, B., Sala, C., Vattchanoff, J., Weinberg, R.J., Worley, P.I. & Sheng, M. (1999) Shank, a novel family of postsynaptic density proteins that bind to the NMDA receptor/PSD-95/GkaP/complex and cortactin. Neuron 23, 569-582.
18. Nakayama, A.Y., Harms, M.B. & Luo, L. (2000) Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons. J. Neurosci., 20, 5329-5338.
19. Nakayama, A.Y. & Luo, L. (2000) Intracellular signaling pathways that regulate dendritic spine morphogenesis. Hippocampus, 10, 582-586.
20. Nogues, X. (1997) Protein kinase C, learning and memory: a circular determinism between physiology and behaviour. Prog. Neuropsychopharmacol. Biol. Psychiatry, 21, 507-529.
21. Obermeier, A., Ahmed, S., Manser, E., Yen, S.C., Hall C. & Lim, L. (1998) PAK promotes morphological changes by acting upstream of Rac. EMBO J., 17, 4328-4339.
22. Okabe, T., Nakamura, T., Nishimura, Y.N., Kohu, K., Ohwada, S., Morishita, Y. & Akiyama, T. (2003) RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. J. Biol. Chem., 278, 9920-9927.
23. Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D. & Hall, A. (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell, 70, 401-410.
24. Schafer, D.A., Welch, M.D., Machesky, L.M., Bridgman, P.C., Meyer, S.M. & Cooper, J.A. (1998) Visualization and molecular analysis of actin assembly in living cells. J. Cell Biol., 143, 1919-1930.
25. Servitja, J.M., Masgrau, R., Pardo, R., Sarri, E., von Eichel-Streiber, C., Gutkind, J.S. & Picatoste, F. (2003) Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway. Neuropharmacology, 44, 171-180.
26. Tashiro, A., Minden, A. & Yuste, R. (2000) Regulation of dendritic spine morphology by the Rho family of small GTPases: antagonistic roles of Rac and Rho. Cerebral Cortex, 10, 927-938.
27. Woo, C.H., Jeong, D.T., Yoon, S.B., Kim, K.S., Chung, I.Y., Saeki, T. & Kim, J.H. (2002) Eotaxin induces migration of RBL-2H3 mast cells via a Rac-ERK-dependent pathway. Biochem. Biophys. Res. Commun., 298, 392-397.
28. Wu, G.Y., Deisseroth, K. & Tsien, R.W. (2001) Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Nat. Neurosci., 4, 151-158.
29. Zhang, W. & Benson, D.L. (2002) Developmentally regulated changes in cellular compartmentation and synaptic distribution of actin in hippocampal neurons. J. Neurosci. Res., 69, 427-436.