Different effects of bone morphogenetic proteins 2, 4, 12, and 13 on the expression of cartilage and bone markers in the MC615 chondrocyte cell line

Experimental Cell Research

Volumn 251, Issue 2, 1999, Pages 264-274

  Valcourt, U ^a   Ronziere M C ^a   Winkler, P ^a   Rosen, V ^b   Herbage, D ^a   Mallein Gerin, F ^a  

^a INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

^b PFIZER INC   (United States)

Author keywords

Bone morphogenetic protein; Cartilage; Chondrocyte differentiation

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 12; BONE MORPHOGENETIC PROTEIN 13; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CARBON 13; COLLAGEN TYPE 10; COLLAGEN TYPE 2; MESSENGER RNA; OSTEOCALCIN; PROLINE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CARTILAGE CELL; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; HUMAN; IN SITU HYBRIDIZATION; MOUSE; NORTHERN BLOTTING; OSTEOBLAST; PHASE CONTRAST MICROSCOPY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALIA; VERTEBRATA;

EID: 0345363018     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4584     Document Type: Article

References (40)

1. Kosher R. A. The chondroblast and the chondrocyte. Hall B. K. Cartilage. 1983;59-85 Academic Press, New York.
2. Hardingham T. E., Fosang A. J., Dudhia J. Aggrecan, the chondroitin sulfate/keratan sulfate proteoglycan from cartilage. Kuettner K. E. Articular Cartilage and Osteoarthritis. 1991;5-20 Raven Press, New York.
3. Bruckner P., van der Rest M. Structure and function of cartilage collagens. Microsc. Res. Tech. 28:1994;378-384.
4. Luo G., D'Souza R., Hogue D., Karsenty G. The matrix gla protein gene is a marker of the chondrogenesis cell lineage during mouse development. J. Bone Miner. Res. 10:1995;325-333.
5. Boivin G., Morel G., Lian J. B., Anthoine-Terrier C., Dubois P. M., Meunier P. J. Localization of endogeneous osteocalcin in neonatal rat bone and its absence in articular cartilage: Effect of warfarin treatment. Virchows Arch. A. Pathol. Anat. Histopathol. 417:1990;505-512.
6. Weinreb M., Shinar D., Rodan G. A. Different pattern of alkaline phosphatase, osteopontin and osteocalcin expression in developing rat bone visualized by in situ hybridization. J. Bone Miner. Res. 5:1990;831-842.
7. Cheah K. S. E., Lau E. T., Au P. K. C., Tam P. L. Expression of the mouse α1(II) collagen gene is not restricted to cartilage during development. Development. 111:1991;945-953.
8. Gentili C., Bianco P., Neri M., Malpeli M., Campanile G., Castagnola P., Cancedda R., Descalzi Cancedda F. Cell proliferation, extracellular matrix mineralisation, and ovotransferrin transient expression during in vitro differentiation of chick hypertrophic chondrocytes into osteoblast-like cells. J. Cell Biol. 122:1993;703-712.
9. Roach H. I., Erenpreisa J., Aigner T. Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis. J. Cell Biol. 131:1995;483-494.
10. Chen Q., Johnson D. M., Haudenschild D. R., Goetinck P. F. Progression and recapitulation of the chondrocyte differentiation program: Cartilage matrix protein is a marker for cartilage maturation. Dev. Biol. 172:1995;293-306.
11. Reddi A. H. Cell biology and biochemistry of endochondral bone development. Collagen Rel. Res. 1:1981;209-226.
12. Mallein-Gerin F., Olsen B. R. Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype. Proc. Nat. Acad. Sci. USA. 90:1993;3289-3293.
13. Mallein-Gerin F., Ruggiero F., Quinn T. M., Bard F., Grodzinsky A. J., Olsen B. R., van der Rest M. Analysis of collagen synthesis and assembly in culture by immortalized mouse chondrocytes in the presence or absence of α1(IX) collagen chains. Exp. Cell Res. 219:1995;257-265.
14. Kokenyesi R., Silbert J. E. Immortalized, cloned mouse chondrocytic cells (MC615) produce three different matrix proteoglycans with core-protein-specific chondroitin/dermatan sulphate structures. Biochem. J. 327:1997;831-839.
15. Ng L. J., Tam P. P. L., Cheah K. S. E. Preferential expression of alternatively spliced mRNAs encoding type II procollagen with a cysteine-rich amino-propeptide in differentiating cartilage and nonchondrogenic tissues during early mouse development. Dev. Biol. 159:1993;403-417.
16. Castagnola P., Moro G., Descalzi-Cancedda F., Cancedda R. Type X collagen synthesis during in vitro development of chick embryo tibial chondrocytes. J. Cell Biol. 102:1986;2310-2317.
17. Feinberg A. P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity: Addendum. Anal. Biochem. 137:1984;266-267.
18. Metsäranta M., Toman D., De Crombrugghe B., Vuorio E. Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. Biochim. Biophys. Acta. 1089:1991;241-243.
19. Wright E., Hargrave M. R., Christiansen J., Cooper L., Kun J., Evans T., Gangadharan U., Greenfield A., Koopman P. The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nature Genet. 9:1995;15-20.
20. Desbois C., Hogue D. A., Karsenty G. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. J. Biol. Chem. 269:1994;1183-1190.
21. Metsäranta M., Toman D., de Crombrugghe B., Vuorio E. Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing. J. Biol. Chem. 266:1991;16862-16869.
22. Apte S. S., Seldin M. F., Hayashi M., Olsen B. R. Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10. Eur. J. Biochem. 206:1992;217-224.
23. Sabath D. E., Broome H. E., Prystowsky M. B. Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte. Gene. 91:1990;185-191.
24. Mallein-Gerin F., Ruggiero F., Garrone R. Proteoglycan core protein and type II collagen gene expressions are not correlated with cell shape changes during low density chondrocyte culture. Differentiation. 43:1990;204-211.
25. Laemmli U. K. Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
26. Wagner T., Wirth J., Meyer J., Zabel B., Held M., Zimmer J., Pasantes J., Bricarelli F. D., Keutel J., Hustert E., Wolf U., Tommerup N., Schemp W., Scherer G. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9. Cell. 79:1994;1111-1120.
27. Ducy P., Desbois C., Boyce B., Pinero G., Story B., Dunstan C., Smith E., Bonadio J., Goldstein S., Gundberg C., Bradley A., Karsenty G. Increased bone formation in osteocalcin-deficient mice. Nature. 382:1996;448-452.
28. Ryan M. C., Sandell L. J. Differential expression of a cysteine-rich domain in the amino-terminal propeptide of type II (cartilage) procollagen by alternative splicing of mRNA. J. Biol. Chem. 265:1990;10334-10339.
29. Lui V. C. H., Ng L. J., Nicholls J., Tam P. P. L., Cheah K. S. E. Tissue-specific and differential expression of alternatively spliced α1(II) collagen mRNAs in early human embryos. Dev. Dyn. 203:1995;198-211.
30. Mayne R., Vail M. S., Mayne P. M., Miller E. J. Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity. Proc. Natl. Acad. Sci. USA. 73:1976;1674-1678.
31. Barone L. M., Owen T. A., Tassinari M. S., Bortell R., Stein G. S., Lian J. B. Developmental expression and hormonal regulation of rat matrix gla protein (MGP) gene in chondrogenesis and osteogenesis. J. Cell. Biochem. 46:1991;351-365.
32. Cancedda R., Descalzi Cancedda F., Castagnola P. Chondrocyte differentiation. Int. Rev. Cytol. 159:1995;265-357.
33. Pacifici M., Golden E. B., Adams S. L., Shapiro I. M. Cell hypertrophy and type X collagen synthesis in cultured articular chondrocytes. Exp. Cell Res. 192:1991;266-270.
34. Ekanayake S., Hall B. K. Hypertrophy is not a prerequisite for type X collagen expression or mineralization of chondrocytes derived from cultured chick mandibular ectomesenchyme. Int. J. Dev. Biol. 38:1994;683-694.
35. Rosen V., Nove J., Song J. J., Thies R. S., Cox K., Wozney J. M. Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone phenotypes. J. Bone Miner. Res. 9:1994;1759-1768.
36. Hale J. E., Fraser J. D., Price P. A. The identification of matrix gla protein in cartilage. J. Biol. Chem. 263:1988;5820-5824.
37. Bianco P., Descalzi Cancedda F., Riminucci M., Cancedda R. Bone formation via cartilage models: The "borderline" chondrocyte. Matrix Biol. 17:1998;185-192.
38. Zou H., Wieser R., Massagué J., Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev. 11:1997;2191-2203.
39. Wozney J. M. The bone morphogenetic protein family: Multifunctional regulators in the embryo and adult. Eur. J. Oral Sci. 106:1998;160-166.
40. Wolfman N. M., Hattersley G., Cox K., Celeste A. J., Nelson R., Yamaji N., Dube J. L., Diblasio-Smith E., Nove J., Song J. J., Wozney J. M., Rosen V. Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J. Clin. Invest. 100:1997;321-330.