Integrin αvβ3 controls activity and oncogenic potential of primed c-Src

Cancer Research

Volumn 67, Issue 6, 2007, Pages 2693-2700

  Huveneers, Stephan ^a,b   Van Den Bout, Iman ^a   Sonneveld, Petra ^a   Sancho, Ana ^a   Sonnenberg, Arnoud ^a   Danen, Erik H J ^a,b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; PROTEIN SH3; STAT3 PROTEIN; VITRONECTIN RECEPTOR;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER SURVIVAL; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; GENE ACTIVATION; GENE ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; TUMOR GROWTH;

ANIMALS; BREAST NEOPLASMS; CELL GROWTH PROCESSES; CELL TRANSFORMATION, NEOPLASTIC; CYTOPLASM; ENZYME ACTIVATION; HUMANS; INTEGRIN ALPHAVBETA3; MICE; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

EID: 34047245477     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-3654     Document Type: Article

References (47)

1. Bissell MJ, Radisky D. Putting tumours in context Nat Rev Cancer 2001;1:46-54.
2. Albelda SM, Mette SA, Elder DE, et al. Integrin distribution in malignant melanoma: association of the β 3 subunit with tumor progression. Cancer Res 1990;50:6757-64.
3. 3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma. Am J Pathol 1998;153:1435-42.
4. 3 in neuroblastic tumors. Am J Pathol 1996;148:1423-34.
5. Vonlaufen A, Wiedle G, Borisch B, Birrer S, Luder P, Imhof BA. Integrin α(v)β(3) expression in colon carcinoma correlates with survival. Mod Pathol 2001; 14:1126-32.
6. 3 integrin receptors in non-malignant and malignant human cervical tumor tissues. J Exp Clin Cancer Res 2001;20:269-75.
7. 3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas. Hum Pathol 1997;28:443-9.
8. 3 integrin receptors in breast tumor. J Exp Clin Cancer Res 2001;20: 585-90.
9. Pignatelli M, Cardillo MR, Hanby A, Stamp GW. Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors. Hum Pathol 1992;23:1159-66.
10. 3 Leu33Pro homozygosity and risk of cancer. J Natl Cancer Inst 2003;95:1150-7.
11. 5 integrins in growth and metastasis of murine mammary carcinomas. Cancer Res 2005;65:10324-9.
12. 5 integrins. Nat Med 2002;8:27-34.
13. Geiger B, Bershadsky A, Pankov R, Yamada KM. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat Rev Mol Cell Biol 2001;2:793-805.
14. Haimovich B, Aneskievich BJ, Boettiger D. Cellular partitioning of β-1 integrins and their phosphorylated forms is altered after transformation by Rous sarcoma virus or treatment with cytochalasin D. Cell Regul 1991; 2:271-83.
15. Sakai T, Jove R. Fassler R, Mosher DF. Role of the cytoplasmic tyrosines of β 1A integrins in transformation by v-src. Proc Natl Acad Sci U S A 2001;98: 3808-13.
16. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin β cytoplasmic domain. Proc Natl Acad Sci U S A 2003;100:13298-302.
17. Danen EH, Yamada KM. Fibronectin, integrins, and growth control. J Cell Physiol 2001;189:1-13.
18. Martin GS. The hunting of the Src. Nat Rev Mol Cell Biol 2001;2:467-75.
19. Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997;13: 513-609.
20. Jove R, Hanafusa H. Cell transformation by the viral src oncogene. Annu Rev Cell Biol 1987;3:31-56.
21. Guy CT, Muthuswamy SK, Cardiff RD, Soriano P, Muller WJ. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev 1994;8:23-32.
22. Matsumoto T, Jiang J, Kiguchi K, et al. Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis. Cancer Res 2003;63:4819-28.
23. Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene 2000;19:5636-42.
24. Niu G, Bowman T, Huang M, et al. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene 2002;21:7001-10.
25. Ishizawar R, Parsons SJ. c-Src and cooperating partners in human cancer. Cancer Cell 2004;6:209-14.
26. Irby RB, Mao W, Coppola D, et al. Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet 1999;21:187-90.
27. Sugimura M, Kobayashi K, Sagae S, et al. Mutation of the SRC gene in endometrial carcinoma. Jpn J Cancer Res 2000;91:395-8.
28. Daigo Y, Furukawa Y, Kawasoe T, et al. Absence of genetic alteration at codon 531 of the human c-src gene in 479 advanced colorectal cancers from Japanese and Caucasian patients. Cancer Res 1999;59:4222-4.
29. Nilbert M, Fernebro E. Lack of activating c-SRC mutations at codon 531 in rectal cancer. Cancer Genet Cytogenet 2000;121:94-5.
30. Felsenfeld DP, Schwartzberg PL, Venegas A, Tse R, Sheetz MP. Selective regulation of integrin-cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol 1999;1:200-6.
31. 3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest 2000;105:433-40.
32. Soriano P, Montgomery C, Geske R, Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 1991;64:693-702.
33. 1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function. J Cell Biol 1999;147: 1325-40.
34. 3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol 2002;159:1071-86.
35. Moissoglu K, Gelman IH. v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts. J Biol Chem 2003;278:47946-59.
36. Ylanne J, Huuskonen J, O'Toole TE, Ginsberg MH, Virtanen I, Gahmberg CG. Mutation of the cytoplasmic domain of the integrin β3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis. J Biol Chem 1995;270:9550-7.
37. Turkson J, Bowman T, Garcia R, Caldenhoven E, De Groot RP, Jove R. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 1998;18:2545-52.
38. Bromberg JF, Horvath CM, Besser D, Lathem WW, Darnell JE, Jr. Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol 1998;18:2553-8.
39. Frame MC. Newest findings on the oldest oncogene; how activated src does it. J Cell Sci 2004;117:989-98.
40. Summy JM, Gallick GE. Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 2003; 22:337-58.
41. Irby R, Mao W, Coppola D, et al. Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential. Cell Growth Differ 1997;8:1287-95.
42. Ellis LM, Staley CA, Liu W, et al. Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src. J Biol Chem 1998; 273:1052-7.
43. 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 1990;60:849-59.
44. 1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts. Oncogene 1999;18: 3852-61.
45. 3 by modulation of transmembrane helix associations. Science 2003;300:795-8.
46. Shattil SJ. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol 2005;15:399-403.
47. Cooper JA, MacAuley A. Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation. Proc Natl Acad Sci U S A 1988;85: 4232-6.