Anticipating clinical integration of genetically tailored tobacco dependence treatment: Perspectives of primary care physicians

Nicotine and Tobacco Research

Volumn 9, Issue 2, 2007, Pages 271-279

  Park, Elyse R ^a   Kleimann, Susan ^b   Shields, Alexandra E ^a   Pelan, Julie A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Kleimann Communication Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINE DERIVATIVE; DESIGNER DRUG; NICOTINE;

ADULT; ARTICLE; CAUCASIAN; CLINICAL EDUCATION; CLINICAL PRACTICE; CONTENT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC RISK; GENOTYPE; HUMAN; INFORMATION PROCESSING; MALE; NICOTINE REPLACEMENT THERAPY; PHARMACOGENETICS; PHYSICIAN ATTITUDE; PREVALENCE; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RACE DIFFERENCE; SMOKING CESSATION; SOCIAL DISCRIMINATION; THEMATIC ANALYSIS; TOBACCO DEPENDENCE; ALLELE; CONTINUING EDUCATION; COUNSELING; GENERAL PRACTITIONER; GENETICS; PRIMARY HEALTH CARE;

ADULT; ALLELES; COUNSELING; DESIGNER DRUGS; EDUCATION, CONTINUING; HUMANS; MALE; NICOTINE; PHYSICIANS, FAMILY; PRIMARY HEALTH CARE; TOBACCO USE DISORDER;

EID: 34047209107     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1080/14622200601078574     Document Type: Article

References (43)

1. Billett, E. A., Richter, M. A., Sam, F., Swinson, R. P., Dai, X. Y., King, N., Badri, F., Sasaki, T., Buchanan, J. A. and Kennedy, J. L. (1998) Investigation of dopamine system genes in obsessive-compulsive disorder. Psychiatric Genetics, 8, pp. 163-169.
2. Burke, W. and Emery, J. (2002) Genetics education for primary-care providers. Nature Reviews Genetics, 3, pp. 561-566.
3. Caulfield, T. (1999) Gene testing in the biotech century: Are physicians ready?. Canadian Medical Association Journal, 161, pp. 1122-1124.
4. Centers for Disease Control and Prevention (2000) Cigarette smoking among adults - United States, 2000. Morbidity and Mortality Weekly Report, 51, pp. 642-645.
5. Centers for Disease Control and Prevention (2003) Cigarette smoking-attributable morbidity - United States, 2000. Morbidity and Mortality Weekly Report, 52, pp. 842-844.
6. A clinical practice guideline for treating tobacco use and dependence: A US Public Health Service report (2000) The Journal of the American Medical Association, 283, pp. 3244-3254.
7. Collins, F. S. (1997) Preparing health professionals for the genetic revolution. The Journal of the American Medical Association, 278, pp. 1285-1286.
8. Comings, D. E., Comings, B. G., Muhleman, D., Dietz, G., Shahbahrami, B., Tast, D., Knell, E., Kocsis, P., Baumgarten, R. and Kovacs, B. W. (1991) The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. The Journal of the American Medical Association, 266, pp. 1793-1800.
9. Comings, D. E., Gade, R., Wu, S., Chiu, C., Dietz, G., Muhleman, D., Saucier, G., Ferry, L., Rosenthal, R. J., Lesieur, H. R., Rugle, L. J. and MacMurray, P. (1997) Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors. Molecular Psychiatry, 2, pp. 44-56.
10. Comings, D. E., Muhleman, D., Ahn, C., Gysin, R. and Flanagan, S. D. (1994) The dopamine D2 receptor gene: A genetic risk factor in substance abuse. Drug and Alcohol Dependence, 34, pp. 175-180.
11. Comings, D. E., Muhleman, D. and Gysin, R. (1996) Dopamine D2 receptor (DRD2) gene and susceptibility to posttraumatic stress disorder: A study and replication. Biological Psychiatry, 40, pp. 368-372.
12. Demmer, L. A., O'Neill, M. J., Roberts, A. E. and Clay, M. C. (2000) Knowledge of ethical standards in genetic testing among medical students, residents, and practicing physicians. The Journal of the American Medical Association, 284, pp. 2595-2596.
13. Emery, J. and Hayflick, S. (2001) The challenge of integrating genetic medicine into primary care. British Medical Journal, 322, pp. 1027-1030.
14. Evans, W. E. and Relling, M. V. (1999) Pharmacogenomics: Translating functional genomics into rational therapeutics. Science, 286, pp. 487-491.
15. Fetters, M. D., Doukas, D. J. and Phan, K. L. D. (1999) Family physicians' perspectives on genetics and the human genome project. Clinical Genetics, 56, pp. 28-34.
16. Freedman, A. N., Wideroff, L., Olson, L., Davis, W., Klabunde, C., Srinath, K. P., Reeve, B. B., Croyle, R. T. and Ballard-Barbash, R. (2003) US physicians' attitudes toward genetic testing for cancer susceptibility. American Journal of Medical Genetics, 120, pp. 63-71.
17. Harris, R. and Harris, H. J. (1995) Primary care for patients at genetic risk. British Medical Journal, 311, pp. 579-580.
18. Hofman, K. L., Tambor, E. S., Chase, G. A., Geller, G., Faden, R. R. and Holtzman, N. A. (1993) Physicians' knowledge of genetics and genetic tests. Academic Medicine, 68, pp. 625-632.
19. Hughes, J. R., Goldstein, M. G., Hurt, R. D. and Shiffman, S. (1999) Recent advances in the pharmacotherapy of smoking. The Journal of the American Medical Association, 281, pp. 72-76.
20. Johnstone, E., Munafo, M., Neville, M., Griffiths, S., Murphy, M. and Walton, R. (2002) Pharmacogenomics of tobacco addiction. Pharmacogenomics: The search for individualized therapies, Wiley-VCH, Los Angeles
21. Johnstone, E. C., Yudkin, P. L., Hey, K., Roberts, S. J., Welch, S. J., Murphy, M. F., Griffiths, S. E. and Walton, R. T. (2004) Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch. Pharmacogenetics, 14, pp. 83-90.
22. Lerman, C., Caporaso, N. E., Audrain, J., Main, D., Bowman, E. D., Lockshin, B., Boyd, N. R. and Shields, P. G. (1999) Evidence suggesting the role of specific genetic factors in cigarette smoking. Health Psychology, 18, pp. 14-20.
23. Lerman, C., Caporaso, N. E., Bush, A., Zheng, Y. L., Audrain, J., Main, D. and Shields, P. G. (2001) Tryptophan hydroxylase gene variant and smoking behavior. American Journal of Medical Genetics, 105, pp. 518-520.
24. Lerman, C. and Niaura, R. (2002) Applying genetic approaches to the treatment of nicotine dependence. Oncogene, 21, pp. 7412-7420.
25. Lerman, C., Shields, P. G., Wileyto, E. P., Audrain, J., Pinto, A., Hawk, L., Krishnan, S., Niaura, R. and Epstein, L. (2002) Pharmacogenetic investigation of smoking cessation treatment. Pharmacogenetics, 12, pp. 627-634.
26. Lerman, C., Wileyto, E. P., Patterson, F., Rukstalis, M., Audrain-McGovern, J., Restine, S., Shields, P. G., Kaufmann, V., Redden, D., Benowitz, N. and Berrettini, W. H. (2004) The functional mu opioid receptor (OPRM1) Asn40Asp variant predicts short-term response to nicotine replacement therapy in a clinical trial. Pharmacogenetics, 4, pp. 184-192.
27. Menasha, J. D., Schechter, C. and Willner, J. (2000) Genetic testing: A physician's perspective. Mount Sinai Journal of Medicine, 67, pp. 144-151.
28. Muglia, P., Jain, U., Macciardi, F. and Kennedy, J. L. (2000) Adult attention deficit hyperactivity disorder and the dopamine D4 receptor gene. American Journal of Medical Genetics, 96, pp. 273-277.
29. Noble, E. P., Jeor, S. T. St, Ritchie, T., Syndulko, K., Jeor, S. C. St, Fitch, R. J., Brunner, R. L. and Sparkes, R. S. (1994) D2 dopamine receptor gene and cigarette smoking: A reward gene?. Medical Hypotheses, 42, pp. 257-260.
30. Park, E. R., Eaton, C. A., Goldstein, M. G., DePue, J., Niaura, R., Guadagnoli, E., MacDonald, N. and Dube, C. (2001) The development of a decisional balance measure of physician smoking cessation interventions. Preventive Medicine, 33, pp. 261-267.
31. Poolsup, N., Po, A. Li Wan and Knight, T. L. (2000) Pharmacogenetics and psychopharmacotherapy. Journal of Clinical Pharmacy and Therapeutics, 25, pp. 197-220.
32. Rose, P. W., Watson, E., Yudkin, P., Emery, J., Murphy, M., Fuller, A. and Lucassen, A. (2001) Referral of patients with a family history of breast/ovarian cancer-GPs' knowledge and expectations. Family Practice, 18, pp. 487-490.
33. Roses, A. D. (2000) Pharmacogenetics and the practice of medicine. Nature, 405, pp. 857-865.
34. Rowe, D. C., Stever, C., Gard, J. M., Cleveland, H. H., Sanders, M. L., Abramowitz, A., Kozol, S. T., Mohr, J. H., Sherman, S. L. and Waldman, I. D. (1998) The relation of the dopamine transporter gene (DAT1) to symptoms of internalizing disorders in children. Behavior Genetics, 28, pp. 215-225.
35. Sabol, S. Z., Nelson, M. L., Fisher, C., Gunzerath, L., Brody, C. L., Hu, S., Sirota, L. A., Marcus, S. E., Greenberg, B. D., Lucas, F. R., Benjamin, J. 4th, Murphy, D. L. and Hamer, D. H. (1999) A genetic association for cigarette smoking behavior. Health Psychology, 18, pp. 7-13.
36. Shields, A. E., Blumenthal, D. B., Weiss, K. B., Comstock, C. B., Currivan, D. and Lerman, C. (2005) Barriers to translating emerging genetics research on smoking into clinical practice: Perspectives of primary care physicians. Journal of General Internal Medicine, 20, pp. 131-138.
37. Shields, P. G., Lerman, C., Audrain, J., Bowman, E. D., Main, D., Boyd, N. R. and Caporaso, N. E. (1998) Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians. Cancer Epidemiology, Biomarkers, and Prevention, 7, pp. 453-458.
38. Silagy, C., Lancaster, T., Stead, L., Mant, D. and Fowler, G. (2002) Nicotine replacement therapy for smoking cessation. Cochrane Database of Systematic Reviews, 4, p. CD000146.
39. Spitz, M. R., Shi, H., Yang, F., Hudmon, K. S., Jiang, H., Chamberlain, R. M., Amos, C. I., Wan, Y., Cinciripini, P., Hong, W. K. and Wu, X. (1998) Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients. Journal of the National Cancer Institute, 90, pp. 358-363.
40. Stratakis, C. A., Cavuto, N., Nelson, D. and Rennert, O. M. (1995) Molecular genetics in pediatric training: How much do we really know?. Maryland Medical Journal, 44, pp. 210-213.
41. Sullivan, P. F., Jiang, Y., Neale, M. C., Kendler, K. S. and Straub, R. E. (2001) Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence. American Journal of Medical Genetics, 105, pp. 479-484.
42. Watson, E. K., Shickle, D., Qureshi, N., Emery, J. and Austoker, J. (1999) The 'new genetics' and primary care: GPs' views on their role and their educational needs. Family Practice, 16, pp. 420-425.
43. Yudkin, P., Munafo, M., Hey, K., Roberts, S., Welch, S., Johnstone, E., Murphy, M., Griffiths, S. and Walton, R. (2004) Effectiveness of nicotine patches in relation to genotype in women versus men: Randomised controlled trial. British Medical Journal, 328, pp. 989-990.