Preclinical evaluation of coronary vascular function after cardioplegia with HTK and different antioxidant additives

European Journal of Cardio-thoracic Surgery

Volumn 31, Issue 5, 2007, Pages 822-827

  Schröder, Cornelia ^a   Heintz, Anke ^a   Pexa, Annette ^a   Rauen, Ursula ^b   Deussen, Andreas ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Coronary flow; Deferoxamine; Langendorff heart; LK 616; Radical scavengers; Trolox

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; BRADYKININ; BUFFER; CREATINE KINASE; DEFEROXAMINE; HTK SOLUTION; LACTATE DEHYDROGENASE; TROLOX C; TROPONIN; 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; BIOLOGICAL MARKER; BRETSCHNEIDER CARDIOPLEGIC SOLUTION; CARDIOPLEGIC AGENT; CHROMAN DERIVATIVE; GLUCOSE; MANNITOL; POTASSIUM CHLORIDE; PRESERVATION SOLUTION; PROCAINE; SIDEROPHORE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; CRYOPRESERVATION; DISEASE MARKER; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART RATE; HYPEREMIA; MALE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; REPERFUSION; TISSUE INJURY; VASODILATATION; ANIMAL; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; DRUG EFFECT; HEART ARREST; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE REPERFUSION; METHODOLOGY; ORGAN PRESERVATION; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; BRADYKININ; CARDIOPLEGIC SOLUTIONS; CHROMANS; CORONARY CIRCULATION; CORONARY VESSELS; DEFEROXAMINE; GLUCOSE; HEART ARREST, INDUCED; HEART RATE; MALE; MANNITOL; MYOCARDIAL REPERFUSION; ORGAN PRESERVATION; ORGAN PRESERVATION SOLUTIONS; POTASSIUM CHLORIDE; PROCAINE; RATS; RATS, WISTAR; SIDEROPHORES; VASODILATION; VASODILATOR AGENTS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 34047181590     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejcts.2007.01.044     Document Type: Article

References (28)

1. Bretschneider H.J. Myocardial protection. Thorac Cardiovasc Surg 28 (1980) 295-302
2. Furchgott R.F., and Zawadzki J.V. The obligatory role of endothelial cells in the relation of arterial smooth muscle by acetylcholine. Nature 228 (1980) 373-376
3. Rauen U., Polzar B., Stephan H., Mannherz H.G., and de Groot H. Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species. FASEB J 13 (1999) 155-168
4. Kevelaitis E., Berg Nyborg N.C., and Menasche P. Coronary endothelial dysfunction of isolated hearts subjected to prolonged cold storage: patterns and contributing factors. J Heart Lung Transplant 18 (1999) 239-247
5. Rauen U., and de Groot H. New insights into the cellular and molecular mechanisms of cold storage injury. J Invest Med 52 (2004) 299-309
6. Huang H., and Salahudeen A.K. Cold induces catalytic iron release of cytochrome P-450 origin: a critical step in cold storage-induced renal injury. Am J Transplant 2 (2002) 631-639
7. Salahudeen A.K. Cold ischemic injury of transplanted kidneys: new insights from experimental studies. Am J Physiol Renal Physiol 287 (2004) F181-F187
8. Haink G., and Deussen A. Liquid chromatography method for the analysis of adenosine compounds. J Chromatogr B Anal Technol Biomed Life Sci 784 (2003) 189-193
9. Deussen A., and Schrader J. Cardiac adenosine production is linked to myocardial pO2. J Mol Cell Cardiol 23 (1991) 495-504
10. 2 formation. FASEB J 14 (2000) 1953-1964
11. Petrat F., de Groot H., Sustmann R., and Rauen U. The chelatable iron pool in living cells: a methodically defined quantity. Biol Chem 383 (2002) 489-502
12. Vairetti M., Ferrigno A., Bertone R., Richelmi P., Bertè F., and Freitas I. Apoptosis vs. necrosis: glutathione-mediated cell death during rewarming of hepatocytes. Biochim Biophys Acta 1740 (2005) 367-374
13. Rauen U., Kerkweg U., Weisheit D., Petrat F., Sustmann R., and de Groot H. Cold-induced apoptosis of hepatocytes: mitochondrial permeability transition triggered by nonmitochondrial chelatable iron. Free Radic Biol Med 35 (2003) 1664-1678
14. Rauen U, Kerkweg U, de Groot H, Iron-dependent vs. iron-independent cold-induced injury to cultured rat hepatocytes: a comparative study in physiological media and organ preservation solutions. Cryobiology, 2006 Dec 24:E pub ahead of print.
15. ATP channels, adenosine, nitric oxide and prostaglandins. Br J Pharmacol 132 (2001) 1209-1216
16. Kelm M., and Schrader J. Control of coronary vascular tone by nitric oxide. Circ Res 66 (1990) 1561-1575
17. Von Kügelgen I., and Wetter A. Molecular pharmacology of P2Y-receptors. Naunyn-Schmiedeberg's Arch Pharmacol 362 (2000) 310-323
18. Fredholm B.B., Arslan G., Halldner L., Kull B., Schulte G., and Wasserman W. Structure and function of adenosine receptors and their genes. Naunyn-Schmiedeberg's Arch Pharmacol 362 (2000) 364-374
19. Deussen A. Metabolic flux rates of adenosine in the heart. Naunyn-Schmiedebergs Arch Pharmacol 362 (2000) 351-363
20. Reddy B.R., Kloner R.A., and Przyklenk K. Early treatment with deferoxamine limits myocardial ischemic/reperfusion injury. Free Radic Biol Med 7 (1989) 45-52
21. Eicher J.C., Gabrielle F., Abadie C., Maupoil V., Wolf J.E., David M., and Rochette L. Experimental preservation of the heart transplant: effects of deferoxamine on functional recovery and lipid peroxidation of the isolated-perfused rat heart subjected to ischemia and reperfusion. Transplant Proc 27 (1995) 1654
22. Sies H., and Murphy M.E. Role of tocopherols in the protection of biological systems against oxidative damage. J Photochem Photobiol B 8 (1991) 211-244
23. Molyneux C.A., Glyn M.C., and Ward B.J. Oxidative stress and cardiac microvascular structure in ischemia and reperfusion: the protective effect of antioxidant vitamins. Microvasc Res 64 (2002) 265-277
24. Rahmani M., Cruz R.P., Granville D.J., and McManus B.M. Allograft vasculopathy versus atherosclerosis. Circ Res 99 (2006) 801-815
25. Weis M., and Cooke J.P. Cardiac allograft vasculopathy and dysregulation of the NO synthase pathway. Arterioscler Thromb Vasc Biol 23 (2003) 567-575
26. Vassalli G, Gallino A, Weis M, von Scheidt W, Kappenberger L, K vSL, Goy J-J, Alloimmunity and nonimmunologic risk factors in cardiac allograft vasculopathy. Eur Heart J 2003;24:1180-8.
27. Stoica S.C., Goddard M., and Large S.R. The endothelium in clinical cardiac transplantation. Ann Thorac Surg 73 (2002) 1002-1008
28. Perrault L.P., and Carrier M. The central role of the endothelium in graft coronary vasculopathy and heart transplantation. Can J Cardiol 21 (2005) 1077-1083