Cold induces catalytic iron release of cytochrome P-450 origin: A critical step in cold storage-induced renal injury

American Journal of Transplantation

Volumn 2, Issue 7, 2002, Pages 631-639

  Huang, Hong ^a   Salahudeen, Abdulla K ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Acute renal failure; Cold storage; Cytochrome P 450 enzymes; Deferoxamine; Free radicals; Iron; Microsomes; Mitochondrial swelling; Transplantation, tubular cells

Indexed keywords

BLEOMYCIN; CIMETIDINE; CYTOCHROME P450; PIPERONYL BUTOXIDE;

ACUTE KIDNEY FAILURE; ARTICLE; CATALYSIS; CELL ULTRASTRUCTURE; COLD INJURY; CRYOPRESERVATION; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IRON KINETICS; KIDNEY INJURY; KIDNEY TRANSPLANTATION; KIDNEY TUBULE EPITHELIUM; LIVER MICROSOME; MICROSOME MEMBRANE; MITOCHONDRION SWELLING;

ADENOSINE; ALLOPURINOL; CATALYSIS; CIMETIDINE; COLD; CYTOCHROME P-450 ENZYME SYSTEM; DEFEROXAMINE; ENZYME INHIBITORS; GLUTATHIONE; HUMANS; INSULIN; IRON; KIDNEY; KIDNEY TUBULES; ORGAN PRESERVATION; ORGAN PRESERVATION SOLUTIONS; RAFFINOSE; UROTHELIUM;

EID: 0036705407     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-6143.2002.20708.x     Document Type: Article

References (30)

1. Green CJ, Healing G, Simpkin S, Fuller BJ, Lunec J. Reduced susceptibility to lipid peroxidation in cold ischemic rabbit kidneys after addition of desferrioxamine, mannitol, or uric acid to the flush solution. Cryobiology 1986; 23: 358-365.
2. Gower JD, Healing G, Fuller BJ, Simpkin S, Green CJ. Protection against oxidative damage in cold-stored rabbit kidneys by desferrioxamine and indomethacin. Cryobiology 1989; 26: 309-317.
3. Zieger MA, Glofcheski DJ, Lepock JR, Kruuv J. Factors influencing survival of mammalian cells exposed to hypothermia. IV. Effects of iron chelation. Cryobiology 1990; 27: 452-464.
4. Zager RA, Conrad DS. Deferoxamine confers striking protection against cold storage injury to isolated mouse proximal tubules. Kidney Int 1996; 50: 2109-2111.
5. Healing G, Gower J, Fuller B, Green C. Intracellular iron redistribution. An important determinant of reperfusion damage to rabbit kidneys. Biochem Pharmacol 1990; 39: 1239-1245.
6. Bysani GK, Kennedy TP, Ky N, Rao NV, Blaze CA, Hoidal JR. Role of cytochrome P-450 in reperfusion injury of the rabbit lung. J Clin Invest 1990; 86: 1434-1441.
7. Paller MS, Jacob HS. Cytochrome P-450 mediates tissue-damaging hydroxyl radical formation during reoxygenation of the kidney. Proc Natl Acad Sci USA 1994; 91: 7002-7006.
8. Baliga R, Zhang Z, Baliga M, Shah SV. Evidence for cytochrome P450 as a source of catalytic iron in myoglobinuric acute renal failure. Kidney Int 1996; 49: 362-369.
9. Evans PJ, Tredger JM, Dunne JB, Halliwell B. Catalytic metal ions and the loss of reduced glutathione from University of Wisconsin preservation solution. Transplantation 1996; 62: 1046-1049.
10. Gutteridge JM, Hou YY. Iron complexes and their reactivity in the bleomycin assay for radical-promoting loosely-bound iron. Free Radic Res Commun 1986; 2: 143-151.
11. Mange KC, Cherikh WS, Maghirang J, Bloom RD. A comparison of the survival of shipped and locally transplanted cadaveric renal allografts. N Engl J Med 2001; 345: 1237-1242.
12. Morita-Fujimura Y, Fujimura M, Kawase M, Chen SF, Chan PH. Release of mitochondrial cytochrome c and DNA fragmentation after cold injury-induced brain trauma in mice: possible role in neuronal apoptosis. Neurosci Lett 1999; 267: 201-205.
13. Adams NH, Levi PE, Hodgson E. Regulation of cytochrome P-450 isozymes by methylenedioxyphenyl compounds. Chem Biol Interact 1993; 86: 255-274.
14. Dahl AR, Hodgson E. The interaction of aliphatic analogs of methylene-dioxyphenyl compounds with cytochromes P-450 and P-420. Chem Biol Interact 1979; 27: 163-175.
15. Rendic S, Kajfez F, Ruf HH. Characterization of cimetidine, ranitidine, and related structures' interaction with cytochrome P-450. Drug Metab Dispos 1983; 11: 137-142.
16. Salahudeen AK. Role of lipid peroxidation in H2O2-induced renal epithelial (LLC-PK1) cell injury. Am J Physiol 1995; 268 (1 Part 2): F30-F38.
17. Salahudeen AK, Joshi M, Jenkins JK. Apoptosis versus necrosis during cold storage and rewarming of human renal proximal tubular cells. Transplantation 2001; 72: 798-804.
18. Paller MS, Hoidal JR, Ferris TF. Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest 1984; 74: 1156-1164.
19. Shah SV, Walker PD. Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol 1988; 255 (3 Part 2): F438-F443.
20. Paller MS. Hemoglobin- and myoglobin-induced acute renal failure in rats: role of iron in nephrotoxicity. Am J Physiol 1988; 255 (3 Part 2): F539-F544.
21. Salahudeen A, Wang C, McDaniel O, Lagoo-Denadyalan S, Bigler S, Barber H. Antioxidant lazaroid U-74006F improves renal function and reduces the expression of cytokines, inducible nitric oxide synthase, and MHC antigens in a syngeneic renal transplant model. Partial support for the response-to-injury hypothesis. Transplantation 1996; 62: 1628-1633.
22. Salahudeen AK, Navaz M, Poovala V et al. Cold storage induces time-dependent F2-isoprostane formation in renal tubular cells and rat kidneys. Kidney Int 1999; 55: 1759-1762.
23. Baird MB, Sfeir GT, Slade-Pacini CD. Lack of inhibition of mouse catalase activity by cimetidine: an argument against a relevant general effect of cimetidine upon heme metabolic pathways. Biochem Pharmacol 1987; 36: 4366-4369.
24. Peters S, Rauen U, Tijen M et al. Cold preservation of isolated rabbit proximal tubules induces radical-mediated cell injury. Transplantation 1998; 65: 625-632.
25. Rauen U, de Groot H. Cold-induced release of reactive oxygen species as a decisive mediator of hypothermia injury to cultured liver cells. Free Radic Biol Med 1998; 24: 1316-1323.
26. Salahudeen AK, Huang H, Patel P, Jenkins JK. Mechanism and prevention of cold storage-induced human renal tubular cell injury. Transplantation 2000; 70: 1424-1431.
27. Salahudeen AA, Jenkins JK, Huang H, Ndebele K, Salahudeen AK. Overexpression of heme oxygenase protects renal tubular cells against cold storage injury: studies using hemin induction and HO-1 gene transfer. Transplantation 2001; 72: 1498-1504.
28. Defraigne JO, Pincemail J, Detry O, Franssen C, Meurisse M, Limet R. Preservation of cortical microcirculation after kidney ischemia-reperfusion: value of an iron chelator. Ann Vasc Surg 1994; 8: 457-467.
29. DeBoer DA, Clark RE. Iron chelation in myocardial preservation after ischemia-reperfusion injury: the importance of pretreatment and toxicity. Ann Thorac Surg 1992; 53: 412-418.
30. Bernardi P, Colonna R, Costantini P et al. The mitochondrial permeability transition. Biofactors 1998; 8: 273-281.