The problem of cough and development of novel antitussives

Pulmonary Pharmacology and Therapeutics

Volumn 20, Issue 4, 2007, Pages 416-422

  Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Antitussives; Cough sensitization; Membrane receptors; Sensory nerves

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 443C81; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; A 317491; ANALGESIC AGENT; ANTITUSSIVE AGENT; CANNABINOID RECEPTOR 2 ANTAGONIST; CANNABINOID RECEPTOR AGONIST; CAPSAZEPINE; CODEINE; FUROSEMIDE; ICATIBANT; LIDOCAINE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MU OPIATE RECEPTOR AGONIST; NIFLUMIC ACID; NOLPITANTIUM; NS 169; OPIATE DERIVATIVE; POTASSIUM CHANNEL STIMULATING AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; PURINE P2X3 RECEPTOR ANTAGONIST; PURINERGIC RECEPTOR BLOCKING AGENT; RIMONABANT; SAREDUTANT; SB 235375; SULINDAC; TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AIRWAY; ARTICLE; CHRONIC DISEASE; CLINICAL FEATURE; CONSTIPATION; COUGHING; DRUG DEPENDENCE; DRUG EFFICACY; DRUG INDICATION; DRUG SAFETY; DRUG TARGETING; HUMAN; IDIOPATHIC DISEASE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; REFLEX; SEDATION; SENSITIZATION; SENSORY NERVE; SIDE EFFECT; SIGNAL TRANSDUCTION; SYMPTOMATOLOGY; TREATMENT OUTCOME;

ACUTE DISEASE; ADMINISTRATION, INHALATION; ANIMALS; ANTITUSSIVE AGENTS; CHRONIC DISEASE; COUGH; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HUMANS; NERVE FIBERS; NOCICEPTORS; REFLEX; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION;

EID: 34047162554     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2006.11.001     Document Type: Article

References (63)

1. Irwin R.S., Curley F.J., and French C.L. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation and outcome of specific therapy. Am Rev Respir Dis 141 (1990) 640-647
2. Schroeder K., and Fahey T. Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev (2004) CD001831
3. Madison J.M., and Irwin R.S. Pharmacotherapy of chronic cough in adults. Expert Opin Pharmacother 4 (2003) 1039-1048
4. Barnes P.J., and Stockley R.A. COPD: current therapeutic interventions and future approaches. Eur Respir J 25 (2005) 1084-1106
5. Lalloo U.G., Lim S., DuBois R., Barnes P.J., and Chung K.F. Increased sensitivity of the cough reflex in progressive systemic sclerosis patients with interstitial lung disease. Eur Respir J 11 (1998) 702-705
6. Haque R.A., Usmani O.S., and Barnes P.J. Chronic idiopathic cough: a discrete clinical entity?. Chest 127 (2005) 1710-1713
7. Jatakanon A., Lalloo U.G., Lim S., Chung K.F., and Barnes P.J. Increased neutrophils and cytokines, TNF-alpha and IL-8, in induced sputum of non-asthmatic patients with chronic dry cough. Thorax 54 (1999) 234-237
8. Chaudhuri R., McMahon A.D., Thomson L.J., Macleod K.J., McSharry C.P., Livingston E., et al. Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. J Allergy Clin Immunol 113 (2004) 1063-1070
9. Niimi A., Torrego A., Nicholson A.G., Cosio B.G., Oates T.B., and Chung K.F. Nature of airway inflammation and remodeling in chronic cough. J Allergy Clin Immunol 116 (2005) 565-570
10. O'Connell F., Springall D.R., Moradoghli-Haftvani A., Krausz T., Price D., Fuller R.W., et al. Abnormal intraepithelial airway nerves in persistent unexplained cough?. Am J Respir Crit Care Med 152 (1995) 2068-2075
11. O'Connell F., Thomas V.E., Studham J.M., Pride N.B., and Fuller R.W. Capsaicin cough sensitivity increases during upper respiratory infection. Respir Med 90 (1996) 279-286
12. Canning B.J. Anatomy and neurophysiology of the cough reflex: ACCP evidence-based clinical practice guidelines. Chest 129 (2006) 33S-47S
13. Fox A.J., Barnes P.J., Urban L., and Dray A. An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J Physiol 469 (1993) 21-35
14. Xu J., Kussmaul W., Kurnik P.B., Al Ahdav M., and Pelleg A. Electrophysiological-anatomic correlates of ATP-triggered vagal reflex in the dog. V. Role of purinergic receptors. Am J Physiol Regul Integr Comp Physiol 288 (2005) R651-R655
15. Patel H.J., Birrell M.A., Crispino N., Hele D.J., Venkatesan P., Barnes P.J., et al. Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation. Br J Pharmacol 140 (2003) 261-268
16. Fox A.J., Lalloo U.G., Belvisi M.G., Bernareggi M., Chung K.F., and Barnes P.J. Bradykinin-evoked sensitization of airway sensory nerves: a mechanism for ACE-inhibitor cough. Nat Med 2 (1996) 814-817
17. Kamei J., Takahashi Y., Yoshikawa Y., and Saitoh A. Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity. Eur J Pharmacol 528 (2005) 158-161
18. Stone R., Barnes P.J., and Fuller R.W. Contrasting effects of prostaglandins E2 and F2 alpha on sensitivity of the human cough reflex. J Appl Physiol 73 (1992) 649-653
19. 2, bradykinin and histamine. Am Rev Respir Dis 140 (1989) 137-141
20. 2-adrenergic and anticholinergic drugs. Thorax 45 (1990) 694-698
21. Hansson P.T., and Dickenson A.H. Pharmacological treatment of peripheral neuropathic pain conditions based on shared commonalities despite multiple etiologies. Pain 113 (2005) 251-254
22. Moalem G., and Tracey D.J. Immune and inflammatory mechanisms in neuropathic pain. Brain Res Brain Res Rev 51 (2006) 240-264
23. Attal N., and Bouhassira D. Translating basic research on sodium channels in human neuropathic pain. J Pain 7 (2006) S31-S37
24. Obata K., and Noguchi K. MAPK activation in nociceptive neurons and pain hypersensitivity. Life Sci 74 (2004) 2643-2653
25. Kumar S., Boehm J., and Lee J.C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2 (2003) 717-726
26. Belvisi M.G., and Geppetti P. Cough. 7: current and future drugs for the treatment of chronic cough. Thorax 59 (2004) 438-440
27. Choudry N.B., Gray S.J., Posner J., and Fuller R.W. The effect of 443C81, a m-opioid receptor agonist, on the response to inhaled capsaicin in healthy volunteers. Br J Clin Pharmacol 32 (1991) 683-686
28. Giuliani S., and Maggi C. Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide. Br J Pharmacol 118 (1996) 1567-1570
29. Lee M.G., Undem B.J., Brown C., and Carr M.J. Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs. Am J Respir Crit Care Med 173 (2006) 271-275
30. Choudry N.B., Fuller R.W., Anderson N., and Karlsson J.A. Separation of cough and reflex bronchoconstriction by inhaled local anaesthetics. Eur Respir J 3 (1990) 579-583
31. Ekberg J., and Adams D.J. Neuronal voltage-gated sodium channel subtypes: key roles in inflammatory and neuropathic pain. Int J Biochem Cell Biol 38 (2006) 2005-2010
32. Stretton C.D., Miura M., Belvisi M.G., and Barnes P.J. Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc Natl Acad Sci USA 89 (1992) 1325-1329
33. Fox A.J., Barnes P.J., Venkatesan P., and Belvisi M.G. Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves. J Clin Invest 99 (1997) 513-519
34. Jia Y., McLeod R.L., Wang X., Parra L.E., Egan R.W., and Hey J.A. Anandamide induces cough in conscious guinea-pigs through VR1 receptors. Br J Pharmacol 137 (2002) 831-836
35. Lalloo U.G., Fox A.J., Belvisi M.G., Chung K.F., and Barnes P.J. Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. J Appl Physiol 79 (1995) 1082-1092
36. Groneberg D.A., Niimi A., Dinh Q.T., Cosio B., Hew M., Fischer A., et al. Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough. Am J Respir Crit Care Med 170 (2004) 1276-1280
37. Geppetti P., Materazzi S., and Nicoletti P. The transient receptor potential vanilloid 1: role in airway inflammation and disease. Eur J Pharmacol 533 (2006) 207-214
38. Szallasi A., Cruz F., and Geppetti P. TRPV1: a therapeutic target for novel analgesic drugs?. Trends Mol Med (2006)
39. Li S., Westwick J., and Poll C. Transient receptor potential (TRP) channels as potential drug targets in respiratory disease. Cell Calcium 33 (2003) 551-558
40. Morice A.H., Marshall A.E., Higgins K.S., and Grattan T.J. Effect of inhaled menthol on citric acid induced cough in normal subjects. Thorax 49 (1994) 1024-1026
41. Laude E.A., Morice A.H., and Grattan T.J. The antitussive effect of menthol, camphor and cineole in conscious guinea pigs. Pulm Pharmacol 7 (1994) 179-184
42. McKemy D.D., Neuhausser W.M., and Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 (2002) 52-58
43. McKemy D.D., Neuhausser W.M., and Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 (2002) 52-58
44. McKemy D.D. How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation. Mol Pain 1 (2005) 16
45. Krishtal O. The ASICs: signaling molecules? Modulators?. Trends Neurosci 26 (2003) 477-483
46. Fox A.J., Barnes P.J., and Dray A. Stimulation of afferent fibres in the guinea pig trachea by non-isomotic and low chloride solutions and its modulation by frusemide. J Physiol 482 (1995) 179-187
47. Ventresca G.P., Nichol G.M., Barnes P.J., and Chung K.F. Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin. Am Rev Respir Dis 142 (1990) 143-146
48. Stone R.A., Barnes P.J., and Chung K.F. Effect of frusemide on cough responses to chloride-deficient solutions in normal and asthmatic subjects. Eur Resp J 6 (1993) 862-867
49. 2a. Br J Clin Pharmacol 33 (1992) 514-516
50. Mazzone S.B., and McGovern A.E. Na+-K+-2Cl- cotransporters and Cl- channels regulate citric acid cough in guinea pigs. J Appl Physiol 101 (2006) 635-643
51. Yates D.H., O'Connor B.J., Yilmaz G., Aikman S., Chen-Worsdell M., Barnes P.J., et al. Effect of acute and chronic inhaled furosemide on bronchial hyperresponsiveness in mild asthma. Am J Respir Crit Care Med 152 (1995) 892-896
52. Girard V., Naline E., Vilain P., Emonds-Alt X., and Advenier C. Effect of the two tachykinin antagonists, SR 48968 and SR 140333, on cough induced by citric acid in the unanaesthetized guinea pig. Eur Respir J 8 (1995) 1110-1114
53. Hay D.W., Giardina G.A., Griswold D.E., Underwood D.C., Kotzer C.J., et al. Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. J Pharmacol Exp Ther 300 (2002) 314-323
54. McEwan J.R., Choudry N.B., and Fuller R.W. The effect of sulindac on the abnormal cough reflex associated with dry cough. J Pharmacol Exp Ther 255 (1990) 161-164
55. Stone R.A., Barnes P.J., and Fuller R.W. The low chloride cough response is not inhibited by a single high dose of aspirin. Br J Clin Pharmacol 34 (1992) 370-373
56. Pezet S., and McMahon S.B. Neurotrophins: mediators and modulators of pain. Annu Rev Neurosci 29 (2006) 507-538
57. Fox A.J., Patel H.J., Barnes P.J., and Belvisi M.G. Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases. Eur J Pharmacol 424 (2001) 159-162
58. Saragovi H.U., and Gehring K. Development of pharmacological agents for targeting neurotrophins and their receptors. Trends Pharmacol Sci 21 (2000) 93-98
59. Basoglu O.K., Pelleg A., Essilfie-Quaye S., Brindicci C., Barnes P.J., and Kharitonov S.A. Effects of aerosolized adenosine 5′-triphosphate vs adenosine 5′-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma. Chest 128 (2005) 1905-1909
60. Chen Y., Li G.W., Wang C., Gu Y., and Huang L.Y. Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain 119 (2005) 38-48
61. Stone R.A., Barnes P.J., and Chung K.F. Effect of 5-HT1A receptor agonist, 8-OH-DPAT, on cough responses in the conscious guinea pig. Eur J Pharmacol 332 (1997) 201-207
62. Choudry N.B., McEwan J.R., Lavender E.A., Williams A.J., and Fuller R.W. Human responses to inhaled capsaicin are not inhibited by granisetron. Br J Clin Pharmacol 31 (1991) 337-339
63. Usmani O.S., Belvisi M.G., Patel H.J., Crispino N., Birrell M.A., Korbonits M., et al. Theobromine inhibits sensory nerve activation and cough. FASEB J 19 (2005) 231-233