The association between fatigue and inflammatory marker levels in cancer patients: A quantitative review

Brain, Behavior, and Immunity

Volumn 21, Issue 4, 2007, Pages 413-427

  Schubert, Christian ^a,b   Hong, Suzi ^b   Natarajan, Loki ^c   Mills, Paul J ^b,c   Dimsdale, Joel E ^b,c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Cancer; Cytokines; Fatigue; Interleukin; Quality of life; Quantitative review; Tumor necrosis factor

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CARNITINE; CORTICOSTEROID; IMMUNOSUPPRESSIVE AGENT; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEOPTERIN; NONSTEROID ANTIINFLAMMATORY AGENT; PACLITAXEL; TUMOR NECROSIS FACTOR ALPHA;

BLOOD SAMPLING; BREAST CANCER; CANCER; CANCER PATIENT; CORRELATION COEFFICIENT; DISEASE ASSOCIATION; DISEASE MARKER; FATIGUE; HUMAN; INFLAMMATION; METHODOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; STATISTICAL ANALYSIS; UTERUS CANCER;

BIOLOGICAL MARKERS; FATIGUE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1ALPHA; INTERLEUKIN-6; NEOPLASMS; NEOPTERIN; STATISTICS;

EID: 34047158255     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2006.11.004     Document Type: Review

References (73)

1. Ahlberg K., Ekman T., and Gaston-Johansson F. Levels of fatigue compared to levels of cytokines and hemoglobin during pelvic radiotherapy: a pilot study. Biol. Res. Nurs. 5 (2004) 203-210
2. Arend W.P., and Dayer J.M. Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum. 33 (1990) 305-315
3. Auzeby A., Bogdan A., Krosi Z., and Touitou Y. Time-dependence of urinary neopterin, a marker of cellular immune activity. Clin. Chem. 34 (1988) 1866-1867
4. Blohmer J.U., Dunst J., Harrison L., Johnston P., Khayat D., Ludwig H., O'Brien M., Van Belle S., and Vaupel P. Cancer-related anemia: biological findings, clinical implications and impact on quality of life. Oncology 68 (2005) 12-21
5. Bogdan C., and Ding A. Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages. J. Leukoc. Biol. 52 (1992) 119-121
6. Bower J.E., Ganz P.A., Aziz N., and Fahey J.L. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosom. Med. 64 (2002) 604-611
7. Bruera E., Brenneis C., Michaud M., Rafter J., Magnan A., Tennant A., Hanson J., and Macdonald R.N. Association between asthenia and nutritional status, lean body mass, anemia, psychological status, and tumor mass in patients with advanced breast cancer. J. Pain Symptom Manage 4 (1989) 59-63
8. Cannon J.G., Angel J.B., Ball R.W., Abad L.W., Fagioli L., and Komaroff A.L. Acute phase responses and cytokine secretion in chronic fatigue syndrome. J. Clin. Immunol. 19 (1999) 414-421
9. Collado-Hidalgo A., Bower J.E., Ganz P.A., Cole S.W., and Irwin M.R. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin. Cancer Res. 12 (2006) 2759-2766
10. Collins T.S., Lee L.F., and Ting J.P. Paclitaxel up-regulates interleukin-8 synthesis in human lung carcinoma through an NF-kappaB- and AP-1-dependent mechanism. Cancer Immunol. Immunother. 49 (2000) 78-84
11. Costanzo E.S., Lutgendorf S.K., Sood A.K., Anderson B., Sorosky J., and Lubaroff D.M. Psychosocial factors and interleukin-6 among women with advanced ovarian cancer. Cancer 104 (2005) 305-313
12. Deeks, J.J., Higgins, J.P.T., Altman, D.G., 2003. Analyzing and presenting results. In: Cochrane Reviewers' Handbook 4.2.2 [updated December 2003], Section 8, Alderson, P., Green, S., Higgins, J., (Eds). [Web Page] http://www.cochrane.org/resources/handbook/hbook.htm (accessed 31st January 2004).
13. Dimeo F., Schmittel A., Fietz T., Schwartz S., Kohler P., Boning D., and Thiel E. Physical performance, depression, immune status and fatigue in patients with hematological malignancies after treatment. Ann. Oncol. 15 (2004) 1237-1242
14. Dinarello C.A. Interleukin-1 and interleukin-1 antagonism. Blood 77 (1991) 1627-1652
15. Duval S., and Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56 (2000) 455-463
16. Espat N.J., Rogy M.A., Copeland E.M., and Moldawer L.L. CMNSG Guest Lecture. Interleukin-1, interleukin-1 receptor, and interleukin-1 receptor antagonist. Proc. Nutr. Soc. 53 (1994) 393-400
17. Fuchs D., Hausen A., Reibnegger G., Werner E.R., Dierich M.P., and Wachter H. Neopterin as a marker for activated cell-mediated immunity: application in HIV infection. Immunol. Today 9 (1988) 150-155
18. Fuchs D., Weiss G., and Wachter H. Neopterin, biochemistry and clinical use as a marker for cellular immune reactions. Int. Arch. Allergy Immunol. 101 (1993) 1-6
19. Geinitz H., Zimmermann F.B., Stoll P., Thamm R., Kaffenberger W., Ansorg K., Keller M., Busch R., van Beuningen D., and Molls M. Fatigue, serum cytokine levels, and blood cell counts during radiotherapy of patients with breast cancer. Int. J. Radiat. Oncol. Biol. Phys. 51 (2001) 691-698
20. Gelinas C., and Fillion L. Factors related to persistent fatigue following completion of breast cancer treatment. Oncol. Nurs. Forum 31 (2004) 269-278
21. Gerain J., Lienard D., Ewalenko P., and Lejeune F.J. High serum levels of TNF-alpha after its administration for isolation perfusion of the limb. Cytokine 4 (1992) 585-591
22. Glass G.V. Primary, secondary, and meta-analysis of research. Educ. Res. 5 (1976) 3-8
23. Gramignano G., Lusso M.R., Madeddu C., Massa E., Serpe R., Deiana L., Lamonica G., Dessi M., Spiga C., Astara G., Maccio A., and Mantovani G. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. Nutrition 22 (2006) 136-145
24. Greenberg D.B., Sawicka J., Eisenthal S., and Ross D. Fatigue syndrome due to localized radiation. J. Pain. Symptom Manage. 7 (1992) 38-45
25. Greenberg D.B., Gray J.L., Mannix C.M., Eisenthal S., and Carey M. Treatment-related fatigue and serum interleukin-1 levels in patients during external beam irradiation for prostate cancer. J. Pain Symptom Manage 8 (1993) 196-200
26. Gudewill S., Pollmächer T., Vedder H., Schreiber W., Fassbender K., and Holsboer F. Nocturnal plasma levels of cytokines in healthy men. Eur. Arch. Psychiatry Clin. Neurosci. 242 (1992) 53-56
27. Hedges L.V., and Olkin I. Statistical Methods for Meta-Analysis (1985), Academic Press, Orlando, FL
28. Herskind C., Bamberg M., and Rodemann H.P. The role of cytokines in the development of normal-tissue reactions after radiotherapy. Strahlenther. Onkol. 174 (1998) 12-15
29. Higgins J.P.T., Thompson S.G., Deeks J.J., and Altman D.G. Measuring inconsistency in meta-analyses. BMJ 327 (2003) 557-560
30. Hinkle D.E., Wiersma W., and Jurs S.G. Applied Statistics for the Behavioral Sciences. Fifth ed. (2003), Houghton Mifflin Company, Boston, New York
31. Irvine D., Vincent L., Graydon J.E., Bubela N., and Thompson L. The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy. A comparison with the fatigue experienced by healthy individuals. Cancer Nurs. 17 (1994) 367-378
32. Kelley K.W., Bluthe R.M., Dantzer R., Zhou J.H., Shen W.H., Johnson R.W., and Broussard S.R. Cytokine-induced sickness behavior. Brain Behav. Immun. 17 (2003) S112-S118
33. Kent S., Bluthe R.M., Kelley K.W., and Dantzer R. Sickness behavior as a new target for drug development. Trends Pharmacol. Sci. 13 (1992) 24-28
34. Knobel H., Loge J.H., Nordoy T., Kolstad A.L., Espevik T., Kvaloy S., and Kaasa S. High level of fatigue in lymphoma patients treated with high dose therapy. J. Pain Symptom Manage 19 (2000) 446-456
35. Kurzrock R. Cytokine deregulation in cancer. Biomed. Pharmacother. 55 (2001) 543-547
36. Kurzrock R. The role of cytokines in cancer-related fatigue. Cancer 92 (2001) 1684-1688
37. Larson S.J., and Dunn A.J. Behavioral effects of cytokines. Brain Behav. Immun. 15 (2001) 371-387
38. Lemmer B., Schwulera U., Thrun A., and Lissner R. Circadian rhythm of soluble interleukin-2 receptor in healthy individuals. Eur. Cytokine Netw. 3 (1992) 335-336
39. Light R.J., and Pillemer D.B. Summing Up: The Science of Reviewing Research (1984), MA Harvard University Press, Cambridge
40. Mantovani G., Maccio A., Madeddu C., Gramignano G., Lusso M.R., Serpe R., Massa E., Astara G., and Deiana L. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol. Biomarkers Prev. 15 (2006) 1030-1034
41. Meyers C.A., Albitar M., and Estey E. Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome. Cancer 104 (2005) 788-793
42. Mills P.J., Parker B., Dimsdale J.E., Sadler G.R., and Ancoli-Israel S. The relationship between fatigue and quality of life and inflammation during anthracycline-based chemotherapy in breast cancer. Biol. Psychol. 69 (2005) 85-96 Epub 2005 Jan 8
43. Mock V., Atkinson A., Barsevick A., Cella D., Cimprich B., Cleeland C., Donnelly J., Eisenberger M.A., Escalante C., Hinds P., Jacobsen P.B., Kaldor P., Knight S.J., Peterman A., Piper B.F., Rugo H., Sabbatini P., and Stahl C. National Comprehensive Cancer Network. NCCN Practice Guidelines for Cancer-Related Fatigue. Oncology (Huntingt.) 14 (2000) 151-161
44. Morant R. Asthenia: an important symptom in cancer patients. Cancer Treat Rev. 22 Suppl. A (1996) 117-122
45. Morant R., Stiefel F., Berchtold W., Radziwill A., and Riesen W. Preliminary results of a study assessing asthenia and related psychological and biological phenomena in patients with advanced cancer. Support. Care Cancer 1 (1993) 101-107
46. Mullins D.W., Burger C.J., and Elgert K.D. Paclitaxel enhances macrophage IL-12 production in tumor-bearing hosts through nitric oxide. J. Immunol. 162 (1999) 6811-6818
47. Murr C., Widner B., Wirleitner B., and Fuchs D. Neopterin as a marker for immune system activation. Curr. Drug Metab. 3 (2002) 175-187
48. Opal S.M., and DePalo V.A. Anti-inflammatory cytokines. Chest 117 (2000) 1162-1172
49. Petrovsky N., and Harrison L.C. Diurnal rhythmicity of human cytokine production: a dynamic disequilibrium in T helper cell type 1/T helper cell type 2 balance?. J. Immunol. 158 (1997) 5163-5168
50. Petrovsky N., McNair P., and Harrison L.C. Diurnal rhythms of pro-inflammatory cytokines: regulation by plasma cortisol and therapeutic implications. Cytokine 10 (1998) 307-312
51. Pollmächer T., Korth C., Schreiber W., Hermann D., and Mullington J. Effects of repeated administration of granulocyte colony-stimulating factor (G-CSF) on neutrophil counts, plasma cytokine, and cytokine receptor levels. Cytokine 8 (1996) 799-803
52. Pollmächer T., Haack M., Schuld A., Reichenberg A., and Yirmiya R. Low levels of circulating inflammatory cytokines-do they affect human brain functions?. Brain Behav. Immun. 16 (2002) 525-532
53. Pusztai L., Mendoza T.R., Reuben J.M., Martinez M.M., Willey J.S., Lara J., Syed A., Fritsche H.A., Bruera E., Booser D., Valero V., Arun B., Ibrahim N., Rivera E., Royce M., Cleeland C.S., and Hortobagyi G.N. Changes in plasma levels of inflammatory cytokines in response to paclitaxel chemotherapy. Cytokine 25 (2004) 94-102
54. Richardson A. Fatigue in cancer patients: a review of the literature. Eur. J. Cancer Care (Engl.) 4 (1995) 20-32
55. Rich T., Innominato P.F., Boerner J., Mormont M.C., Iacobelli S., Baron B., Jasmin C., and Levi F. Elevated serum cytokines correlated with altered behavior, serum cortisol rhythm, and dampened 24-h rest-activity patterns in patients with metastatic colorectal cancer. Clin. Cancer Res. 11 (2005) 1757-1764
56. Rosenthal R. Quality-weighting of studies in meta-analytic research. Psychother. Res. 1 (1991) 25-28
57. Rosenthal R. Meta-analytic procedures for social research (1991), Sage Publications, Newbury Park
58. Rosenthal R., and DiMatteo M.R. Meta-Analysis: recent developments in quantitative methods for literature reviews. Annu. Rev. Psychol. 52 (2001) 59-82
59. Savard J., Simard S., Ivers H., and Morin C.M. Randomized study on the efficacy of cognitive-behavioral therapy for insomnia secondary to breast cancer, part II: immunologic effects. J. Clin. Oncol. 23 (2005) 6097-6106
60. Schubert C., Lampe A., Rumpold G., Fuchs D., König P., Chamson E., and Schüssler G. Daily psychosocial stressors interfere with the dynamics of urine neopterin in a patient with systemic lupus erythematosus: an integrative single-case study. Psychosom. Med. 61 (1999) 876-882
61. Schubert C., Lampe A., Geser W., Noisternig B., Fuchs D., König P., Chamson E., and Schüssler G. Daily psychosocial stressors and cyclic response patterns in urine cortisol and neopterin in a patient with systemic lupus erythematosus. Psychoneuroendocrinology 28 (2003) 459-473
62. Schwartz A.L. Daily fatigue patterns and effect of exercise in women with breast cancer. Cancer Pract. 8 (2000) 16-24
63. Shafqat A., Einhorn L.H., Hanna N., Sledge G.W., Hanna A., Juliar B.E., Monahan P., and Bhatia S. Screening studies for fatigue and laboratory correlates in cancer patients undergoing treatment. Ann. Oncol. 16 (2005) 1545-1550
64. Smyth M.J., Cretney E., Kershaw M.H., and Hayakawa Y. Cytokines in cancer immunity and immunotherapy. Immunol. Rev. 202 (2004) 275-293
65. Swiergiel A.H., Smagin G.N., Johnson L.J., and Dunn A.J. The role of cytokines in the behavioral responses to endotoxin and influenza virus infection in mice: effects of acute and chronic administration of the interleukin-1-receptor antagonist (IL-1ra). Brain Res. 776 (1997) 96-104
66. Thavasu P.W., Longhurst S., Joel S.P., Slevin M.L., and Balkwill F.R. Measuring cytokine levels in blood. Importance of anticoagulants, processing, and storage conditions. J. Immunol. Methods 153 (1992) 115-124
67. Vgontzas A.N., Papanicolaou D.A., Bixler E.O., Lotsikas A., Zachman K., Kales A., Prolo P., Wong M.L., Licinio J., Gold P.W., Hermida R.C., Mastorakos G., and Chrousos G.P. Circadian interleukin-6 secretion and quantity and depth of sleep. J. Clin. Endocrinol. Metab. 84 (1999) 2603-2607
68. Visser M.R., and Smets E.M. Fatigue, depression and quality of life in cancer patients: how are they related? Support. Care Cancer 6 (1998) 101-108
69. Wang X.S., Giralt S.A., Mendoza T.R., Engstrom M.C., Johnson B.A., Peterson N., Broemeling L.D., and Cleeland C.S. Clinical factors associated with cancer-related fatigue in patients being treated for leukemia and non-Hodgkin's lymphoma. J. Clin. Oncol. 20 (2002) 1319-1328
70. White C.M., Martin B.K., Lee L.F., Haskill J.S., and Ting J.P. Effects of paclitaxel on cytokine synthesis by unprimed human monocytes, T lymphocytes, and breast cancer cells. Cancer Immunol. Immunother. 46 (1997) 104-112
71. World Health Organization, 1994. Cancer pain relief and palliative care. Technical report series, 804, Geneva, 1990.
72. Wratten C., Kilmurray J., Nash S., Seldon M., Hamilton C.S., O'Brien P.C., and Denham J.W. Fatigue during breast radiotherapy and its relationship to biological factors. Int. J. Radiat. Oncol. Biol. Phys. 59 (2004) 160-167
73. Zagozdzon R., and Golab J. Immunomodulation by anticancer chemotherapy: more is not always better (review). Int. J. Oncol. 18 (2001) 417-424