Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide-A preferential cyclooxygenase-2 inhibitor

Toxicology

Volumn 234, Issue 1-2, 2007, Pages 135-144

  Balaji, Thotakura ^a   Ramanathan, Manickam ^a   Menon, Venugopal Padmanabhan ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Cyclooxygensase 2; Fertility; Mice; Nimesulide; Prostaglandins; Vas deferens

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; ISOENZYME; MITOGENIC AGENT; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; STEROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SAFETY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME REPRESSION; EPITHELIUM CELL; INFLAMMATION; MALE; MALE FERTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; SPERMATOZOON MOTILITY; VAS DEFERENS;

ANIMALS; APOPTOSIS; CELL NUCLEUS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOCOSAHEXAENOIC ACIDS; EPITHELIAL CELLS; FATTY ACIDS, UNSATURATED; FEMALE; FERTILITY; IMMUNOCHEMISTRY; LITTER SIZE; MALE; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROVILLI; PROSTAGLANDINS; SPERM COUNT; SPERM MOTILITY; SULFONAMIDES; VACUOLES; VAS DEFERENS;

MUS;

EID: 34047153890     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.02.011     Document Type: Article

References (60)

1. Alexander J., Travis, and Kopf G.S. The role of cholesterol efflux in regulating the fertilization potential of mammalian spermatozoa. J. Clin. Invest. 110 6 (2002) 731-736
2. Agnes V.F., and Akbarsha M.A. Sperm toxic effect of aflatoxin B1 in the albino mouse. Food Chem. Toxicol. 41 (2003) 119-130
3. Balasubramaniam J. Selective COX-2 inhibitors and nephrotoxicity. Am. J. Kidney Dis. 36 (2000) 675-676
4. Bartke A., and Koerner S. Androgenic regulation of the concentration of prostaglandin F in the male reproductive system of rats and mice. Endocrinology 95 (1974) 1739-1743
5. Beche F., Scheuerer S., Brune K., Geisslinger G., and Strache G.M. Upregulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation. FEBS Lett. 390 (1996) 165-169
6. Bejarano P.F. Management of inflammatory pain with selective COX-2 inhibitors: promises and facts. Curr. Rev. Pain 3 (1999) 432-439
7. Botting R.M. Cyclooxygenase past present and future a tribute to John R. Vane (1927-2004). J. Therm. Biol. 34 (2006) 208-219
8. Breder C.T., Dewitt D., and Kraig R.P. Characterisation of inducible cyclooxygenase in rat brain. J. Comp. Neurol. 355 (1995) 296-315
9. Chan T.A., Morin P.J., Vogelstein B., and Kinzler K.W. Mechanisms underlying nonsteroidal anti-inflammatory drug-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 681-686
10. Chandrasekaran N.V., Dai H., Roos K.L., Evanson N.K., Tomsik J., Elton T.S., and Simmon D.L. COX-3 a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure and expression. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 13926-13931
11. Cheuk B.L.Y., Chew S.B.C., Fiscus R.K., and Wong P.Y.D. Cycloxygenase-2 regulates apoptosis in rat epididymis through prostaglandin D2. Biol. Reprod. 66 (2002) 374-380
12. Cicek Y., Özmen I., Canakci V., Dilsiz A., and Sahin F. Content and composition of fatty acids in normal and infl{ligature}amed gingival tissues. Prostaglandins Leukot. Essent. Fatty Acids 72 (2005) 147-151
13. Colon J., Ginsburg F., Lessing J., Schoenfeld C., Goldsmith L.T., Amelar R.D., Dublin L., and Weiss G. The effect of relaxin and prostaglandin E2 on the motility of human spermatozoa. Fertil. Steril. 46 (1986) 1133-1139
14. Cryer B., and Dubois A. The advent of highly selective inhibitors of cyclooxygenase A review. Prostaglandins Other Lipid Mediat. 56 (1998) 341-361
15. 2+ in sperm physiology. Int. Rev. Cytol. 243 (2005) 79-172
16. Didolkar A.K., Patel P.B., and Choudary D.R. Effects of aspirin on spermatogenesis in mature and immature rats. Int. J. Androl. 3 (1980) 585-591
17. Folch J., Lees M., and Sloane Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 33 (1957) 497-509
18. Fries F.J., Williams C.A., Ramey D., and Bloch D.A. The relative toxicity of disease modifying antirheumatic drugs. Arthritis Rheum. 36 (1993) 296-300
19. Gerozissis K., and Dray F. Selective and age dependent changes of prostaglandin E-2 in the epididymis and vas deferens of the rat. J. Reprod. Fertil. 50 (1977) 113-115
20. Gibb W., and Sun M. Localization of prostaglandin H synthase type 2 protein and mRNA in term human fetal membranes and decidua. J. Endocrinol. 150 (1996) 497-503
21. Green K., Christensen N., and Bygdeman M. The chemistry and pharmacology of prostaglandin with reference to human reproduction. J. Reprod. Fertil. 62 (1981) 269-281
22. Gross G., Imamur T., and Vogt S.K. Inhibition of cyclooxygenase-2 prevents inflammation mediated pre-term labour in the mouse. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278 (2000) 1415-1423
23. Gupta S.K., Bansal P., Bharadwaj R.K., and Velpandian T. Comparitive anti-nociceptive, anti-inflammatory and toxicity profile of nimesulide vs. nimesulide and piperine combination. Pharmacol. Res. 4 (2000) 657-662
24. Gupta S.K., Velpandian T., Mathur P., and Sengupta S. Comparative analgesic activity of nimesulide and diclofenac by intramuscular route: correlation with pharmacokinetic profile of nimesulide. Pharmacology 56 (1998) 137-143
25. Haluska P.V., Mais D.E., Mayeux P.R., and Morinelli T.A. Thromboxane, prostaglandin and leukotriene receptors. Annu. Rev. Pharmacol. Toxicol. 10 (1989) 213-239
26. Hamberg M., and Samuelson B. Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 70 (1973) 899-903
27. Hamilton D.W., Jones A.L., and Fawcet D.W. Cholesterol biosynthesis in the mouse epididymis and ductus deferens: a biochemical and morphological study. Biol. Reprod. 1 (1969) 104-167
28. Harris R.C., McKanna J.A., Akai Y., Jacobson H.R., Dubois R.N., and Breyer M.D. Cyclooxygense-2 is associated with macula densa of rat kidney and increases with salt restriction. J. Clin. Invest. 94 (1994) 2504-2510
29. Kelly R.W. Prostaglandin synthesis in the male and female reproductive tract. J. Reprod. Fertil. 62 (1981) 293-304
30. Kennedy J.H., Korn N., and Thurston R.J. Prostaglandin levels in seminal plasma and sperm extracts of the domestic turkey, and the effects of cyclooxygenase inhibitors on sperm mobility. Reprod. Biol. Endocrinol. 1 (2003) 74-87
31. Kern S., and Maddocks S. Indomethacin blocks the immunosuppressive activity of rat testicular macrophages cultured in vitro. J. Reprod. Immunol. 28 (1995) 189-201
32. Kirschenbaum A., Liotta D.R., Yao S., Xin-Hua L., Klausner A.P., Unger P., Shapiro E., Leau I., and Levine A.C. Immunohistochemical localization of cyclooxygenase-1 and cyclooxygenase-2 in the human fetal and adult male reproductive tracts. J. Clin. Endocrinol. Metab. 85 (2000) 3436-3441
33. Klein L.A., and Stoff J.S. Prostaglandin synthesis is independent of androgen levels in rat male genitalia. J. Lab. Clin. Med. 109 4 (1987) 402-408
34. Kumar P., and Bansal M.P. Effect of selenium induced oxidative stress on the cell kinetics in testis and reproductive ability of mice. Nutrition 21 (2005) 351-357
35. Lazarus M., Munday C.J., Eguchi N., Matsumoto S., Killian G.J., Kubata B.K., and Urade Y. Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology 143 (2002) 2410-2419
36. Lazarus M., Eguchi N., Matsumoto S., Nagata N., Yana T., Killian G.J., and Urade Y. Species specific expression of microsomal Prostaglandin E synthase-1 and cyclooxygenases in male monkey reproductive organs. Prostaglandins Leukot. Essent. Fatty Acids 71 (2004) 233-240
37. Lim H., Pama B.C., Das S.K., Dinchuk J.E., Langenbach K., Trzaskos J.M., and Dey S.K. Multiple female reproductive failures in cyclooxygense-2 deficient mice. Cell 91 (1997) 197-208
38. Manjunath P., and Therien I. Role of seminal plasma phospholipids binding protein in sperm membrane lipid modification that occur during capacitation. J. Reprod. Immunol. 53 (2002) 109-119
39. Matson J.R., Strokes J.B., and Robillard J.E. Effects of inhibition of prostaglandin synthesis on fetal renal function. Kidney Int. 20 (1981) 612-627
40. McKanna J.A., Zhang M.Z., Wang J.L., Cheng H.F., and Harris R.C. Constitutive expression of cyclooxygenase-2 in rat vas deferens. Am. J. Physiol. Regul. Integr. Comp. Physiol. 275 (1998) 227-233
41. Mingatto F.E., Rodrigues T., Pigoso A.A., Uyemura S.A., Curtis C., and Santos A.C. The critical role of mitochondrial energetic impairment in the toxicity of nimesulide to hepatocytes. J. Pharmacol. Exp. Ther. 303 (2002) 601-607
42. Mitra K., and Shivaji S. Proteins implicated in sperm capacitation. Indian J. Exp. Biol. 43 (2003) 1001-1015
43. Monjazeb A.M., High K.P., Koumenis C., and Chilton F.H. Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in neoplastic cell. Prostaglandins Leukot. Essent. Fatty Acids 73 (2005) 463-474
44. Nagatsuki S., Terada N., Yoshimura T., Horie Y., and Furukawa M. Effect of nimesulide, a preferential cyclooxygenase-2 inhibitor on carrageenan induced pleurisy and stress induced gastric lesion in rats. Prostaglandins Leukot. Essent. Fatty Acids 55 (1996) 395-402
45. Neeraja S., Sreenath A.S., Reddy P.R.K., and Reddanna P. Expression of cyclooxygenase-2 in rat testis. Reprod. Biomed. Online 6 (2003) 300-307
46. Patra P.B., Wadsworth R.M., Hay D.W., and Zeitlin I.J. The effect of inhibition of prostaglandin formation in contraction of the rat, rabbit and human vas deferens. J. Auton. Pharmacol. 10 (1990) 55-63
47. Rogind H., and Bliddal H. Comparison of etodolac and piroxicam in patients with osteoarthritis of hip or knee. A prospective, randomized, double-blind, controlled multicenter study. Clin. Drug Invest. 13 (1997) 66-75
48. Schaefer M., Hofmann T., Schultz G., and Gidermann T. A new prostaglandin E receptor mediated calcium influx and acrosome reaction in human spermatozoa. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 3008-3013
49. Seibert K., and Masferrer J.L. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptors 4 (1994) 17-23
50. Shafiq N., Malhotra S., and Pandhi P. Comparison of non selective cyclooxygenase (cox) inhibitors and selective cox-2 inhibitors on preimplantation loss, post implantation loss and duration of gestation: an experimental study. Contraception 69 (2004) 71-75
51. Shalev Y., Shemesh M., Levinshal T., Marcus S., and Breitbart H. Localization of cyclooxygenase and production of prostaglandins in bovine spermatozoa. J. Reprod. Fertil. 101 (1994) 405-413
52. Shimizu Y., Yorimitsu A., Maruyama T., Kubota T., Aso T., and Bronson R.A. Prostaglandins induce calcium influx in human spermatozoa. Mol. Hum. Reprod. 4 (1998) 555-561
53. Simmons D.L., Botting R.M., and HLA T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol. Rev. 56 (2004) 387-437
54. Talbot P., and Chacon R.S. A triple stain technique for evaluating normal acrosome reactions of human sperm. J. Exp. Zool. 215 (1981) 201-208
55. Tilley S.L., Audoly L.P., Hicks E.H., Kims H.S., Plannery P.J., Coffman T.M., and Koller B.H. Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor. J. Clin. Invest. 103 (1999) 1539-1545
56. Tvrzicka E., Cvrckova E., M'aca B., and Jiraskova M. Changes in the liver, kidney and heart fatty acid composition following administration of ibuprofen to mice. J. Chromatogr. B: Biomed. Sci. Appl. 656 (1994) 51-57
57. Weinreb M., Kelner A., and Keil S. Inhibition of cyclooxygenase-2 activity does not abolish the metabolic effect of prostaglandin E2 in vivo or in vitro. J. Endocrinol. 174 (2002) 127-135
58. Wong P.Y.D., Chan H.C., Leung P.S., Chung Y.W., Wong Y.L., Lee W.M., Ng V., and Dun N.J. Regulation of anion secretion by cyclooxygenase and prostanoids in cultured epididymal epithelia from rat. J. Physiol. 514 (1999) 809-820
59. Yaksh T.L., and Svensson C. Role of spinal cyclooxygenases in nocicepive processing. In: Vane J.R., and Botting R.M. (Eds). Therapeutic Roles of Selective Cox-2 Inhibitors (2001), William Harvey Press, London 168-190
60. Zhang M.Z., Wang J.L., Cheng H.F., Harris R.C., and Mckanna J.B. Cyclooxygenas-2 in rat nephron development. Am. J. Physiol. 273 (1997) 994-1002