Spermatotoxic effect of aflatoxin B1 in the albino mouse

Food and Chemical Toxicology

Volumn 41, Issue 1, 2003, Pages 119-130

  Agnes, V F ^a   Akbarsha, M A ^a  

^a BHARATHIDASAN UNIVERSITY   (India)

Author keywords

Aflatoxin B1; Cytoplasmic droplet; Epididymis; Sperm abnormalities; Sperm counts; Sperm motility; Testis

Indexed keywords

AFLATOXIN B1; ALCOHOL; CORN OIL; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONEME; BODY WEIGHT; CELL INCLUSION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; CYTOPLASM; ELECTRON MICROSCOPY; EPIDIDYMIS; EPIDIDYMIS TAIL; EXPERIMENTAL MODEL; LAMELLAR BODY; MALE; MALE FERTILITY; MICROSCOPY; MOUSE; NONHUMAN; REPRODUCTIVE TOXICITY; SPERMATOZOON; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON DENSITY; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; SUSPENSION; TESTIS;

AFLATOXIN B1; ANIMALS; EPIDIDYMIS; FEMALE; FERTILITY; INJECTIONS, INTRAPERITONEAL; LITTER SIZE; MALE; MICE; MICROSCOPY, ELECTRON; RANDOM ALLOCATION; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; TESTIS;

ANIMALIA; ZEA MAYS;

EID: 0037210230     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(02)00171-0     Document Type: Article

References (50)

1. Agnes V.F., Akbarsha M.A. Pale vacuolated epithelial cell in the epididymis of aflatoxin-treated mice. Reproduction. 122:2001;629-641.
2. Akbarsha M.A., Averal H.I. Epididymis as target organ for the toxic effect of vincrstine. light microscopic changes in the epididymal epithelial cell types Biomedical Letters. 54:1996;133-146.
3. Akbarsha M.A., Stanley A., Averal H.I. Effect of vinscristine on Leydig cell and accessory reproductive organs. Current Science. 68:1995;1053-1056.
4. Akbarsha M.A., Latha P.N., Murugaian P. Retention of cytoplasmic droplet by rat cauda epididymal spermatozoa after treatment with cytotoxic agents. Journal of Reproduction and Fertility. 120:2000;385-390.
5. Boekelheide K. Sertoli cell toxicants. Russell L.D., Griswold M.D. The Sertoli Cell. 1993;551-575 Cache River Press, Clearwater, FL.
6. Boockfor F.R., Blake C.A. Chronic administration of 4-tert-octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. Biology of Reproduction. 57:1997;267-277.
7. Bradbury J. It's not looking good for sperm counts. Lancet. 350:1997;1605.
8. Bremner W.J., Millar M.R., Sharpe R.M., Saunders P.T.K. Immunohistochemical localization of androgen receptors in the rat testis. evidence for stage-dependent expression and regulation by androgens Endocrinology. 135:1994;1227-1234.
9. Carlsen E., Giwercman A., Keiding S., Skakkebaek N.E. Evidence for decreasing quality of semen during the past 50 years. British Medical Journal. 305:1992;609-613.
10. Carlsen E., Giwercman A., Skakkebaek N.E., Keiding N. Decreasing quality of semen. British Medical Journal. 306:1993;461.
11. Clarke R.N., Doerr J.A., Ottinger M.A. Relative importance of dietary aflatoxin and feed restriction on reproductive changes associated with aflatoxicosis in the maturing white leghorn male. Poultry Science. 65:1986;2239-2245.
12. Cooper T.G. Interactions between epididymal secretions and spermatozoa. Journal of Reproduction and Fertility. (suppl.):1998;119-136.
13. Egbunike G.N. Steroidogenic and spermatogenic potentials of the male rat after acute treatment with aflatoxin B1. Andrologia. 14:1982;440-446.
14. Egbunike G.N. Sperm maturation and storage in the male rat after acute treatment with aflatoxin B1. Andrologia. 17:1985;379-382.
15. Egbunike G.N., Emerole G.O., Aire T.A., Ikegwuonu F.I. Sperm production rates, sperm physiology and fertility in rats chronically treated with sublethal doses of aflatoxin B1. Andrologia. 12:1980;467-475.
16. Gist D.H., Hess R.A., Thurston R.J. Cytoplasmic droplets of painted turtle spermatozoa. Journal of Morphology. 214:1992;153-158.
17. Gomendio M., Cassinello J., Roldan E.R. A comparative study of ejaculate in three endangered ungulates with different levels of inbreeding. fluctuating asymmetry as an indicator of reproductive and genetic stress Proceedings of the Royal Society of London B Biological Science. 267:2000;875-882.
18. Groopman J.D., Wang J.S., Scholl P. Molecular biomarkers for aflatoxins. from adducts to gene mutations to human liver cancer Canadian Journal of Physiology and Pharmacology. 74:1996;203-209.
19. Hafez A.H., Megalla S.E., Mohamed A.A. Aflatoxin and aflatoxicosis. effect of dietary aflatoxin on the morphology of buffalo bull spermatozoa Mycopathologia. 77:1982;141-144.
20. Hermo L., Dworkin J., Oko R. Role of epithelial clear cells of the rat epididymis in the disposal of the contents of cytoplasmic droplets detached from spermatozoa. American Journal of Anatomy. 183:1988;107-124.
21. Hess R.A., Moore J.D. Histological methods for evaluation of testis. Chapin E., Heindel J. Methods in Toxicology, Vol. 3A. 1973;52-58 Academic Press, New York.
22. Hruban Z., Martan J., Aschenbrenner I. Polarized cylindrical body in the epididymis of the flying squirrel. Journal of Morphology. 135:1971;87-97.
23. Ibeh I.N., Saxena D.K. Effect of alpha-tocopherol supplementation on the impact of aflatoxin B1 of the testes of rats. Experimental Toxicology and Pathology. 50:1998;221-224.
24. Ibeh I.N., Uraih N., Ogonar J.I. Dietary exposure to aflatoxin in human male infertility in Benin City, Nigeria. International Journal of Fertility and Menopausal Studies. 39:1994;208-214.
25. Jackson A.E., O'Leary P., Ayers M.M., De Krester D.M. The effects of ethylene dimethanesulphonate (EDS) on rat Leydig cells. eveidence to support a connective tissue origin of Leydig cells Biology of Reproduction. 35:1986;425-437.
26. Kendall N.R., McMullen S., Green A., Rodway R.G. The effect of a zinc, cobalt and selenium soluble glass bolus on trace element status and semen quality of ram lambs. Animal Reproduction Science. 62:2000;277-283.
27. Krausz C., Forti G. Clinical aspects of male infertility. McElreavey K. The Genetic Basis of Male Infertility. 2000;1-21 Springer, Heidelberg.
28. Mace K., Aguilar F., Wang J.S., Vautravers P., Gomez-Lechon M., Gonzalez F.J., Groopman J., Harris C.C., Pfeifer A.M. Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. Carcinogenesis. 18:1997;1291-1297.
29. Meistrich M.L., Goldstein L.S., Wyrobek A.J. Long-term infertility and dominant lethal mutations in male mice treated with adriamycin. Mutation Research. 152:1985;53-65.
30. Moreno R.D., Ramalho-Santos J., Chan E.K., Wessel G.M., Schatten G. The Golgi apparatus segregates from the lysosomal/acrosomal vesicle during rhesus monkey spermiogenesis. structural alterations Developmental Biology. 219:2000;334-349.
31. Nakai M., Hess R.A. Morphological changes in the rat Sertoli cell induced by microtubule poison carbendazim. Tissue and Cell. 26:1994;917-927.
32. Oko R., Hermo L., Chan P.T., Fazel A., Bergeron J.J. The cytoplasmic droplet of rat epididymal spermatozoa contains saccular elements with Golgi characteristics. Journal of Cell Biology. 123:1993;809-821.
33. Picha J., Cerovcky J., Pichova D. Fluctuation in the concentration of sex steroids and aflatoxin B1 in the seminal plasma of boars and its relation to sperm production. Veterinary Medicine (Praha). 31:1986;347-357.
34. Raphael S.S. Cytologic diagnosis. Culling C.F.A., Mellor M.D., Spencer F., Thomsons W.B. Lynch's Medical Laboratory Technology. 1976;833 W.B. Saunders & Company, Toronto.
35. Redenbach D.M., Vogl A.W. Microtubule polarity in Sertoli cells. a model for microtubule-based spermatid transport European Journal of Cell Biology. 54:1991;277-290.
36. Richburg J.H. The relevance of spontaneous- and chemically-induced alterations in testicular germ cell apoptosis to toxicology. Toxicology Letters. 15:2000;79-86.
37. Robaire B., Hermo L. Efferent ducts, epididymis and vas deferens. structure, fuctions and their regulation Knobil E., Neill J. The Physiology of Reproduction, Vol. 1. 1988;999-1080 Raven Press, New York.
38. Robaire B., Viger R.S. Regulation of epididymal epithelial functions. Zirkin B.R., Whitecomb R. Understanding Male Infertility: Basic and Clinical Approaches. 1995;183-210 Raven Press, New York.
39. Ronis M.J.J., Badger T.M., Shema S.J., Roberson P.K., Shaikh F. Reproductive toxicity and growth effects in rats exposed to lead at different periods during development. Toxicology and Applied Pharmacology. 136:1996;337-361.
40. Russell L.D., Russell A.J. Short-term morphological response of the rat testis to administration of five chemotherapeutic agents. American Journal of Anatomy. 192:1991;142-168.
41. Sawyer D.E., Hillman G.R., Uchida T., Brown D.B. Altered nuclear activation parameters of rat sperm treated in vitro with chromatin-damaging agents. Toxicological Science. 44:1998;52-62.
42. Sharlin J.S., Howarth B., Wyatt R.D. Effect of dietary aflatoxin on reproductive performance of mature White Leghorn males. Poultry Science. 59:1980;1311-1315.
43. Sharpe R.M. Are environmental chemicals a threat to male fertility? Chemistry and Industry. 3:1992;88-94.
44. Sharpe R.M., Skakkebaek N.E. Are estrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 341:1993;1392-1395.
45. Sotomayor R.E., Sahu S., Washington M., Hinton D.M., Chou M. Temporal patterns of DNA adduct formation and glutathione S- transferase activity in the testes of rats fed with aflatoxin B1. a comparison with patterns in the liver Environmental and Molecular Mutagenesis. 33:1999;293-302.
46. Steeno O.P., Pangkahila A. Occupational influences on male fertility and sexuality. Andrologia. 16:1984;5-22.
47. Turner T.T. On the epididymis and its role in the development of the fertile ejaculate. Journal of Andrology. 16:1995;292-298.
48. Vogl A.W., Pfeiffer D.C., Redenbach D.M. Ectoplasmic ("junctional") specializations in mammalian Sertoli cells. influence on spermatogenic cells Annals of the New York Academy of Sciences. 637:1991;175-202.
49. Wang J.S., Groopman J.D. DNA damage by mycotoxins. Mutation Research. 8:1999;167-181.
50. Wine R.N., Li L.H., Barnes L.H., Gulati D.K., Chapin R.E. Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. Environmental Health Perspectives. 105:1997;102-107.