Antiproliferative effects of conjugated linoleic acid on human colon adenocarcinoma cell line Caco-2

Asia Pacific Journal of Clinical Nutrition

Volumn 16, Issue SUPPL.1, 2007, Pages 432-436

  Huang, Guidong ^a,b   Zhong, Xianfeng ^b   Cao, Yusheng ^a   Chen, Yan ^a  

^a NANCHANG UNIVERSITY   (China)

^b HENAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antiproliferation; Caco 2; Conjugated linoleic acid

Indexed keywords

9,11 LINOLEIC ACID; 9,11-LINOLEIC ACID; ANTINEOPLASTIC AGENT; CONJUGATED LINOLEIC ACID; UNCLASSIFIED DRUG;

CELL DIVISION; CELL STRAIN CACO 2; COLON TUMOR; CONFERENCE PAPER; DOSE RESPONSE; DRUG EFFECT; HUMAN; ISOMERISM; TIME; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENTS; CACO-2 CELLS; CELL DIVISION; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOMERISM; LINOLEIC ACIDS, CONJUGATED; TIME FACTORS; TREATMENT OUTCOME;

ANIMALIA;

EID: 34047136163     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (28)

1. Pariza MW and Ha YL. Conjugated dienoic derivatives of linoleic acid: a new class of anti- carcinogens. Med Oncol Tumor Pharmacother 1990; 7:169-171.
2. Kloss R, Linscheid J, Johnson A, Lawson B, Edwards K, Linder T, Stocker K, Petitte J and Kern M. Effects of conjugated linoleic acid supplementation on blood lipids and adiposity of rats fed diets rich in saturated versus unsaturated fat. Pharmacol Res 2005; 51: 503-507.
3. Kritchevsky D, Tepper SA, Wright S, Czarnecki SK, Wilson TA and Nicolosi RJ. Conjugated linoleic acid isomer effects in atherosclerosis: growth and regression of lesions. Lipids 2004; 39: 611-616.
4. Houseknecht KL, Vanden HJ P, MoyaCamarena SY, Portocarrero CP, Peck LW, Nickel KP and Belury MA. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem-Biophys Res Commun 1998; 244: 678-682.
5. O'Shea M, Bassaganya-Riera J and Mohede IC. Immunomodulatory properties of conjugated linoleic acid. Am J Clin Nutr 2004; 79: 1199S-1206S.
6. Shultz TD, Chew BP and Seaman WR. Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Anticancer Res 1992; 12: 2143-2145.
7. Zhang H, Guo Y and Yuan J. Conjugated linoleic acid enhanced the immune function in broiler chicks. Br J Nutr 2005; 94: 746-752.
8. Lai C, Yin J, Li D, Zhao L and Chen X. Effects of dietary conjugated linoleic acid supplementation on performance and immune function of weaned pigs. Arch Anim Nutr 2005; 59: 41-51.
9. House RL, Cassady JP, Eisen EJ, McIntosh MK and Odle J. Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue. Obes Rev 2005; 6: 247-258.
10. Ringseis R, Saal D, Muller A, Sternhart H and Eder K. Dietary conjugated linoleic acids lower the triacylglycerol concentration in the milk of lactating rats and impair the growth and increase the mortality of their suckling pups. J Nutr 2004; 134: 3327-3334.
11. Zhao L, Yin J, Li D, Lai C, Chen X and Ma D. Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. Arch Anim Nutr 2005; 59: 429-438.
12. Ringseis R, Muller A, Herter C, Gahler S, Steinhart H and Eder K. CLA isomers inhibit TNFalpha-induced eicosanoid release from human vascular smooth muscle cells via a PPARgamma ligand-like action. Biochim Biophys Acta 2006; 1760: 290-300.
13. McEntee MF and Whelan J. Dietary polyunsaturated fatty acids and colorectal neoplasia. Biomed Pharmacother 2002; 56: 380-387.
14. Durgam VR and Fernandes G. The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. Cancer Lett. 1997; 116: 121-130.
15. Liu JR, Li BX, Chen BQ, Han XH, Xue YB, Yang YM, Zheng YM and Liu RH. Effect of cis-9, trans-11-conjugated linoleic acid on cell cycle od gastric adenocarcinoma cell line (SGC-7901). World J Gastroenterol 2002; 8: 224-229.
16. Kim Kh and Park HS. Dietary supplementation of conjugated linoleic acid reduces colon tumor incidence in DMH-treated rats by increasing apoptosis with modulation of biomarkers. Nutrition 2003; 19: 772-777.
17. Yamasaki M, Chujo H, Koga Y, Oishi A, Rikimaru T, Shimada M, Sugimachi K, Tachibana H and Yamada K. Potent cytotoxic effect of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells. Cancer Lett 2002; 188: 171-180.
18. Miller A, Stanton C and Devery R. Cis 9, trans 11- and trans 10, cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells. Anticancer Res 2002; 22: 3879-3887.
19. Kim EJ, Kang IJ, Cho HJ, Kim WK, Ha YL and Park JH. Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. J Nutrition 2003; 133: 2675-2681.
20. Igarashi M and Miyazawa. The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells. Biochim Biophys Acta 2001; 1530:162-171.
21. Kim EJ, Jun JG, Park HS, Kim SM, Ha YL and Park JH. Conjugated linoleic acid (CLA) inhibites growth of Caco-2 colon cancer cells: possible mediation by Oleamide. Anticancer Research 2002; 22: 2193-2198.
22. O'Shea M, Stanton C and Devery R. Antioxidant enzyme defense responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid, Anticancer Res. 1999; 19: 1953- 1959.
23. Kim EJ, Holthuizen PE, Park HS, Ha YL, Jung KC, Park JH. Trans-10, cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth. Am J Physiol Gastrointest Liver Physiol 2002; 23: G357-367.
24. Cho HJ, Kim WK, Kim EJ, Jung KC, Park S, Lee HS, Tyner AL and Park JH. Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. Am J Physiol Gastrointest Liver Physiol 2003; 284: G996-G1005.
25. Kemp MQ, Jeffy BD and Romagnolo DF. Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells. J Nutrition 2003; 133: 3670-3677.
26. Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD and Wahle KW. Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers. Carcinogenesis 2004; 25:1185-1191.
27. Palombo D, Ganguly A, Bistrian BR and Menard MP. The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells. Cancer Lett 2002; 177: 163-172.
28. Cho HJ, Kim WK, Jung JI, Kin EJ, Lim SS, Kwon DY and Park JH. Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells. World J Gastroenterol 2005; 11: 5142-5150.