Osteoprotegerin expression in dendritic cells increases with maturation and is NF-κB-dependent

Journal of Cellular Biochemistry

Volumn 100, Issue 6, 2007, Pages 1430-1439

  Schoppet, Michael ^a,b   Hehser, Stephanie ^a   Ruppert, Volker ^a   Stübig, Thomas ^a   Al Fakhri, Nadia ^a   Maisch, Bernhard ^a   Hofbauer, Lorenz C ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Antigen presenting cells; Dendritic cells; Immune system; NF B; Osteoprotegerin

Indexed keywords

CALCITRIOL; CD40 LIGAND; CD83 ANTIGEN; CYTOKINE; DEXAMETHASONE; DOUBLE STRANDED RNA; HORMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; POLYINOSINIC POLYCYTIDYLIC ACID; SMALL INTERFERING RNA; TAMOXIFEN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN TISSUE; IMMUNOASSAY; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOREGULATION; MONOCYTE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STEADY STATE; TONSIL; TRANSCRIPTION REGULATION;

BLOTTING, NORTHERN; CELL DIFFERENTIATION; CHOLECALCIFEROL; DENDRITIC CELLS; DEXAMETHASONE; DINOPROSTONE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE SILENCING; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; INTERLEUKIN-1BETA; INTERLEUKIN-6; MICROSCOPY, CONFOCAL; NF-KAPPA B; OSTEOPROTEGERIN; RANK LIGAND; RNA, SMALL INTERFERING; TAMOXIFEN; TUMOR NECROSIS FACTOR-ALPHA; VITAMINS;

EID: 34047118525     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21129     Document Type: Article

References (34)

1. Ashcroft AJ, Cruickshank SM, Croucher PI, Perry MJ, Rollinson S, Lippitt JM, Child JA, Dunstan C, Felsburg PJ, Morgan GJ, Carding SR. 2003. Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity 19:849-861.
2. Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature 392:245-252.
3. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. 2000. Immunobiology of dendritic cells. Annu Rev Immunol 18:767-811.
4. 2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood 104:1404-1410.
5. Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, Boyle WJ, Simonet WS. 1998. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12:1260-1268.
6. Cella M, Salio M, Sakakibara Y, Langen H, Julkunen I, Lanzavecchia A. 1999. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J Exp Med 189:821-829.
7. Cremer I, Dieu-Nosjean MC, Marechal S, Dezutter-Dambuyant C, Goddard S, Adams D, Winter N, Menetrier-Caux C, Sautes-Fridman C, Fridman WH, Mueller CG. 2002. Long-lived immature dendritic cells mediated by TRANCE-RANK interaction. Blood 100:3646-3655.
8. Golledge J, McCann M, Mangan S, Lam A, Karan M. 2004. Osteoprotegerin and osteopontin are expressed at high concentrations within symptomatic carotid atherosclerosis. Stroke 35:1636-1641.
9. Griffin MD, Lutz W, Phan VA, Bachman LA, McKean DJ, Kumar R. 2001. Dendritic cell modulation by 1α,25 dihydroxyvitamin D3 and its analogs: A vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc Natl Acad Sci USA 98:6800-6805.
10. Hofbauer LC, Schoppet M. 2004. Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular disease. JAMA 292:490-495.
11. Hofbauer LC, Shui C, Riggs BL, Dunstan CR, Speisberg TC, O'Brien T, Khosla S. 2001. Effects of immunosuppressants on receptor activator of NF-κB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells. Biochem Biophys Res Commun 280:334-339.
12. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan HL, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia XZ, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ. 1999. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96:3540-3545.
13. Komi J, Lassila O. 2000. Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells. Blood 95:2875-2882.
14. Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. 1999. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397:315-323.
15. 3-induced, NF-κB-dependent survival factor for endothelial cells. J Biol Chem 275:20959-20962.
16. Miga AJ, Masters SR, Durell BG, Gonzalez M, Jenkins MK, Maliszewski C, Kikutani H, Wade WF, Noelle RJ. 2001. Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions. Eur J Immunol 31:959-965.
17. Mosheimer BA, Kaneider NC, Feistritzer C, Djanani AM, Sturn DH, Patsch JR, Wiedermann CJ. 2005. Syndecan-1 is involved in osteoprotegerin-induced chemotaxis in human peripheral blood monocytes. J Clin Endocrinol Metab 90:2964-2971.
18. Neumann M, Fries H, Scheicher C, Keikavoussi P, Kolb-Maurer A, Brocker E, Serfling E, Kampgen E. 2000. Differential expression of Re1/NF-κB and octamer factors is a hallmark of the generation and maturation of dendritic cells. Blood 95:277-285.
19. Palframan RT, Jung S, Cheng G, Weninger W, Luo Y, Dorf M, Littmann DR, Rollins BJ, Zweerink H, Rot A, von Andrian UH. 2001. Inflammatory chemokine transport and presentation in HEV: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J Exp Med 194:1361-1373.
20. Pfaffl MW. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:2002-2007.
21. Piemonti L, Monti P, Allavena P, Sironi M, Soldini L, Leone BE, Socci C, Di Carlo V. 1999. Glucocorticoids affect human dendritic cell differentiation and maturation. J Immunol 162:6473-6481.
22. Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P. 1998. Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med 188:2175-2180.
23. Romani N, Reider D, Heuer M, Ebner S, Kampgen E, Eibl B, Niederwieser D, Schuler G. 1996. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Methods 196:137-151.
24. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Eliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM. Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ, Amgen EST Program. 1997. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89:159-161.
25. Steinman RM, Hawiger D, Nussenzweig MC. 2003. Tolerogenic dendritic cells. Annu Rev Immunol 21:685-711.
26. Summers KL, Hock BD, McKenzie JL, Hart DNJ. 2001. Phenotypic characterization of five dendritic cell subsets in human tonsils. Am J Pathol 159:285-295.
27. Takahashi K, Asagoe K, Zaishun J, Yanai H, Yoshino T, Hayashi K, Akagi T. 1998. Heterogeneity of dendritic cells in human superficial lymph node: In vitro maturation of immature dendritic cells into mature or activated interdigitating reticulum cells. Am J Pathol 153:745-755.
28. Toruner M, Fernandez-Zapico M, Sha JJ, Pham L, Urrutia R, Egan LJ. 2006. Anti-anoikis effect of nuclear factor-κB through upregulated expression of osteoprotegerin, BCL-2 and IAP-1. J Biol Chem 281:8686-8696.
29. Wong BR, Josien R, Lee SY, Sauter B, Li HI, Steinman RM, Choi Y. 1997. TRANCE (tumor necrosis [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med 186:2075-2080.
30. Wong BR, Josien R, Choi Y. 1999. TRANCE is a TNF family member that regulates dendritic cell and osteoclast function. J Leukoc Biol 65:715-724.
31. Yilmaz A, Lochno M, Traeg F, Cicha I, Reiss C, Stumpf C, Raaz D, Anger T, Amann K, Probst T, Ludwig J, Daniel WG, Garlichs CD. 2004. Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaque. Atherosclerosis 176:101-110.
32. Yun TJ, Chaudhary PM, Shu GL, Frazer JK, Ewings MK, Schwartz SM, Pascual V, Hood LE, Clark EA. 1998. OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. J Immunol 161:6113-6121.
33. Yun TJ, Tallquist MD, Aicher A, Rafferty KL, Marshall AJ, Moon JJ, Ewings MK, Mohaupt M, Herring SW, Clark EA. 2001. Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. J Immunol 166:1482-1491.
34. Yurkovetsky ZR, Shurin GV, Barry DA, Schuh AC, Shurin MR, Robbins PD. 2006. Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells. J Gene Med 8:129-137.