Non-steroidal antiestrogens induce apoptosis in HL60 and MOLT3 leukemic cells involvement of reactive oxygen radicals and protein kinase C

Anticancer Research

Volumn 19, Issue 3 A, 1999, Pages 2089-2093

  Hayon, Tamar ^a   Dvilansky, Alexander ^a   Oriev, Leonid ^a   Nathan, Ilana ^a,b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

Antioxidants; Apoptosis; HL60; MOLT3; Triphenylethylene antiestrogens

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIESTROGEN; ANTILEUKEMIC AGENT; CLOMIFENE; NAFOXIDINE; OXYGEN RADICAL; PROTEIN KINASE C; TAMOXIFEN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; T LYMPHOBLAST;

ACETYLCYSTEINE; ANTINEOPLASTIC AGENTS, HORMONAL; ANTIOXIDANTS; APOPTOSIS; CLOMIPHENE; ENZYME ACTIVATION; ENZYME INHIBITORS; ESTROGEN ANTAGONISTS; HL-60 CELLS; HUMANS; INDOLES; LEUKEMIA, T-CELL, ACUTE; MALEIMIDES; NAFOXIDINE; NEOPLASM PROTEINS; OXIDATIVE STRESS; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; TAMOXIFEN; VITAMIN E;

EID: 0032805804     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Jordan VC: The strategic use of antiestrogens to control the development and growth of breast cancer. Cancer 70 (4 suppl): 977, 1992.
2. Coezy E, Borgna JL, Rochefort H: Tamoxifen and metabolites in MCF Cells: Corlelation between cell binding to estrogen receptor and inhibition of cell growth. Cancel Res 42: 317, 1982.
3. Reddel RR, Murphy LC, Hall RE, Sutherland RL: Differential sensitivity of human breast cancer cell lines to the growth inhibitory effects of tamoxifen. Cancer Res 45: 1525.
4. Croxtal YD, Emmas C, White JO, Choudhary Q, Flower RY: Tamoxiten inhibits growth of estrogen receptor-negative A549 cells. Biochem Pharmacol 47: 197, 1994.
5. Jiang SY, Shyu RY, Heh MY, Jordan VC: Tamoxifen inhibits hepatoma cell growth through an estrogen receptor independent mechanism. J Hepatol 23: 712, 1995.
6. Rosenberg L, Barkun AM, Dennis MH, Pollak M: Low dose octreotide and tamoxifen in the teratment of adenocarcinoma of the Pancreas. Cancer 75: 23, 1995.
7. Lissoni P, Paolorossi F, Tancini G, Ardizzoia A, Barni S, Brivio F, Maestroni GJ, Chilelli M: A phase II study of tamoxifen plus melatonin in metastatic solid tumour patients. Br J Cancer 74: 1466, 1996.
8. Ziv Y, Fazio VW, Kitago K, Gupta MK, Sawady J, Nishioka K: Effect of tamoxifen on 1,2-dimethylhydrazine-HCl-induced colon carcinogenesis in Rats. Anti Gancer Res 17: 803, 1997.
9. Buzaid AC, Murren J: Chemotherapy for advanced malignant melanoma Int J Clin Lab Res 21 (3): 205, 1992.
10. Couldwell WT, Weiss MH, DeGirgio CM, Weiner LP, Hinton DR. Ehresmann GR, Conti PS, Apuzzo ML: Clinical and radiographic response in a minority of patients with recurent malignant gliomas treated with high-dose tamoxifen. Neurosurgery 32, 483, 1993.
11. Su HD, Mazzei GY, Vogler WR, Kuo YF: Effect of tamoxifen, a nonsteroidal antiestrogen on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary. Chem Phalmacol 34: 3649, 1985.
12. O'Brien CA, Liskamp RM, Soloman DH, Weinstein IB: Inhibition of protein kinase C by tamoxifen. Cancer Res 45: 2462, 1985.
13. Cheng AL, Chuang SE, Fine RL, Yeh KH, Liao CM, Lay YD, Chen DS: Inhibition of the membrane translocation and activation of protein kinase C and potentiation of doxorubicin-induced apoptosis of hepatocellular carcinoma cells by tamoxifen. Biochem Pharmacol 55: 523, 1998.
14. Gundimeda U, Chen AH, Gopalakrishna R: Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem 271: 13504, 1996.
15. Cabot MC, Zhang A, Cao H, Lavie Y, Guiliano AE, Han TY, Jones RC: Tamoxifen activates cellular- phospholipase C and D and elicits protein kinase C translocation. Int J Cancer 70: 567, 1997.
16. Lam HYB: Tamoxifen is a calmodulin antagonist in the activation of cAMP-phosphodiesterase. Biochem Biophys Res Commun 118: 27, 1984.
17. Prefers K et al: In vitro drug sensitivity of cells from children with leukemia using MTT assay with improved culture conditions. Blood 76: 2327, 1990.
18. Sellins KS, Cohen YY: Gene induction by γ irradiation leads to DNA fragmentation in lymphocytes. J Immunol 139 (100): 3199, 1987.
19. Watts CKW, Murphy LC, Sutherland RL: Microsomal binding sites for nonsteroidall anti-estrogens in MCF 7 human mammary carcinoma cells. J Biol Chem 259(7): 4223, 1984.
20. Tang BL, Teo CC, Sim KY, Ng ML, Kon OL: Cytostatic effect of antiestrogens in lymphoid cells relationship to high affinity antiestrogen-binding sites and cholesterol. Biochim Biophys Acta 1014: 162, 1989.
21. Biswas R, Vonderhaar BK: Antiestrogen inhibition of prolactin-induced growth of the Nl-2 rat lymphoma cell line. Cancer Res 49: 6295, 1989.
22. Hashimoto M, Inoue S, Muramatsu M, Hasliah E: Estrogens stimulate tamoxifen-induced neuronal cell apoptosis in vitro: A possible nongenomic action. Biochem Biophys Res Commun 240: 464, 1997.
23. Gelman EP: Tamoxifen induction of apoptosis in estrogen receptor-negative cancers: New tricks fol an old dog. J Natl Cancer Inst 88(5): 279, 1996.
24. Gorodinsky M, Nathan I, Dvilansky A: In vitro elfect of non-steroidal anti-estrogenic drugs on B lymphocytes from chronic lymphocytic leukemic patients. In: Guigon M, ed. The negative regulation of hematopoietic cell growth and differentiation. Montlouge: John Libbey Eurotext Limited, 1993, p. 271.
25. Berman E, Adams M, Doigou-Osterndorf R, Godfrey L, Clarkson B, Andreeff M: Effect of tamoxifen on cell lines displaying the multidrug-resistant phenotype. Blood 7: 818, 1991.
26. Treon SP, Teoh G, Urashima M, Ogata A, Chauhan D, Webb IY, Anderson KC: Antiestrogens induced apoptosis in multiple myeloma cells. Blood 92: 1757, 1998.