An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1- β-d-ribofuranoside

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2285-2288

  Ujjinamatada, Ravi K ^a   Baier, Andrea ^b   Borowski, Peter ^b   Hosmane, Ramachandra S ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b JOHN PAUL II CATHOLIC UNIVERSITY OF LUBLIN   (Poland)

Author keywords

AICAR analogue; In vitro screening; Inhibition of Flaviviridae NTPase helicase; Synthesis; West Nile virus (WNV) and hepatitis C virus (HCV)

Indexed keywords

4 CARBAMOYL 5 (4,6 DIAMINO 2,5 DIHYDRO 1,3,5 TRIAZIN 2 YL)IMIDAZOLE 1 BETA DEXTRO RIBOFURANOSIDE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ALCOHOL; DNA; GUANIDINE; HELICASE; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DENGUE VIRUS; DRUG SCREENING; DRUG SYNTHESIS; HEPATITIS C VIRUS; IC 50; IN VITRO STUDY; JAPANESE ENCEPHALITIS VIRUS; NONHUMAN; WEST NILE FLAVIVIRUS;

AMINOIMIDAZOLE CARBOXAMIDE; ANTIVIRAL AGENTS; FLAVIVIRIDAE; HEPACIVIRUS; HUMANS; INHIBITORY CONCENTRATION 50; NUCLEOSIDE-TRIPHOSPHATASE; RIBONUCLEOSIDES; RIBONUCLEOTIDES; RNA HELICASES; WEST NILE VIRUS;

DENGUE VIRUS; FLAVIVIRIDAE; HEPATITIS C VIRUS; JAPANESE ENCEPHALITIS VIRUS; RNA VIRUSES; WEST NILE VIRUS;

EID: 33947723774     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.074     Document Type: Article

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