Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against Flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus

Journal of Medicinal Chemistry

Volumn 46, Issue 19, 2003, Pages 4149-4164

  Zhang, Ning ^a   Chen, Huan Ming ^a   Koch, Verena ^b   Schmitz, Herbert ^b   Liao, Ching Len ^c   Bretner, Maria ^a,d   Bhadti, Vishweshwar S ^a,e   Fattom, Ali I ^e   Naso, Robert B ^e   Hosmane, Ramachandra S ^a   Borowski, Peter ^b  

^a UNIVERSITY OF MARYLAND   (United States)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^e Nabi Biopharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIAMINO 8 IMINO 8H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5 E][1,3]DIAZEPINE 5' TRIPHOSPHATE; 5,8 DIOXO 5,6,7,8 TETRAHYDRO 4H 1 BETA DEXTRO RIBOFURANOSYLIMIDAZO[4,5 E][1,2,4]TRIAZEPINE 5' TRIPHOSPHATE BIS(TRIETHYLAMMONIUM); 6 AMINO 1 (2' DEOXY ALPHA DEXTRO ERYTHROPENTOFURANOSYL) 4,5 DIHYDRO 8H IMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; 6 AMINO 1 (2' DEOXY BETA DEXTRO ERYTHROPENTOFURANOSYL) 4,5 DIHYDRO 8H IMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; 6 AMINO 1 [(2 BENZYLOXYETHOXY)METHYL] 4,5 DIHYDRO 8H IMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; 6 AMINO 1 [(2 HYDROXYETHOXY)METHYL] 4,5 DIHYDRO 8H IMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; 6 AMINO 1 [(2 PHOSPHONYLMETHOXY)ETHYL] 4,5 DIHYDRO 8H IMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; 6 AMINO 4,5 DIHYDRO 8H 1 (2' O METHYL BETA DEXTRO RIBOFURANOSYL)IMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; 6 AMINO 4,5 DIHYDRO 8H IMIDAZO[4,5 E][1,3]DIAZEPINE 4,8 DIONE; ADENOSINE TRIPHOSPHATASE; DIAZEPINE DERIVATIVE; ENZYME INHIBITOR; HELICASE; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ALLOSTERISM; ARTICLE; BINDING SITE; DRUG BINDING; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HEPATITIS C VIRUS; HUMAN; IC 50; IN VITRO STUDY; JAPANESE ENCEPHALITIS VIRUS; NONHUMAN; STRUCTURE ANALYSIS; WEST NILE FLAVIVIRUS;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AZEPINES; DNA; DNA HELICASES; ENCEPHALITIS VIRUS, JAPANESE; ENZYME INHIBITORS; FLAVIVIRIDAE; HEPACIVIRUS; HUMANS; INHIBITORY CONCENTRATION 50; NUCLEOSIDES; NUCLEOTIDES; POLYPROTEINS; VIRAL NONSTRUCTURAL PROTEINS; WEST NILE VIRUS;

EID: 0141567430     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030842j     Document Type: Article

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