Identification of an Sp factor-dependent promoter in GCET, a gene expressed at high levels in germinal center B cells

Molecular Immunology

Volumn 41, Issue 12, 2004, Pages 1145-1153

  Steinke, John W ^a   Hodsdon, Wendy ^b   Parenti, Sarah ^b   Ostraat, Rachel ^b   Lutz, Ryan ^b   Borish, Larry ^a   Hagman, James ^b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Germinal center B cell specific transcription; Lymphoma marker gene; Prognostic marker.; Spl Sp3

Indexed keywords

GERMINAL CENTER EXPRESSED TRANSCRIPTION FACTOR; MESSENGER RNA; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BINDING ASSAY; BINDING SITE; CELL SPECIFICITY; CELL TYPE; CONSENSUS SEQUENCE; CONTROLLED STUDY; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE SEQUENCE; GERMINAL CENTER; MOUSE; NONHUMAN; NUCLEASE PROTECTION ASSAY; PRIORITY JOURNAL; PROMOTER REGION; TATA BOX; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE;

ANIMALS; B-LYMPHOCYTES; BINDING SITES; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GERMINAL CENTER; MICE; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION INITIATION SITE;

MURINAE;

EID: 5144227314     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2004.06.031     Document Type: Article

References (30)

1. A.A. Alizadeh, M.B. Eisen, R.E. Davis, C. Ma, I.S. Lossos, A. Rosenwald, J.C. Boldrick, H. Sabet, T. Tran, X. Yu, J.I. Powell, L. Yang, G.E. Marti, T. Moore, J. Hudson, L. Lu, D.B. Lewis, R. Tibshirani, G. Sherlock, W.C. Chan, T.C. Greiner, D.D. Weisenburger, J.O. Armitage, R. Warnke, R. Levy, W. Wilson, M.R. Grever, J.C. Byrd, D. Botstein, P.O. Brown, and L.M. Staudt Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling Nature 403 2000 503 511
2. A.A. Alizadeh, and L.M. Staudt Genomic-scale gene expression profiling of normal malignant immune cells Curr. Opin. Immunol. 12 2000 219 225
3. K.L. Block, Y. Shou, and M. Poncz An Ets/Spl interaction in the 5′-flanking region of the megakaryocyte-specific allb gene appears to stabilize Spl binding and is essential for expression of this TATA-less gene Blood 88 1996 2071 2080
4. P. Bouwman, H. Gollner, H.-P. Elsasser, G. Eckhoff, A. Karis, F. Grosveld, S. Philipsen, and G. Suske Transcription factor Sp3 is essential for post-natal survival and late tooth development EMBO J. 19 2000 655 661
5. M.R. Briggs, J.T. Kadonaga, S.P. Bell, and R. Tjian Purification and biochemical characterization of the promoter-specific transcription factor Spl. Sci. 234 1986 47 52
6. H.D. Brightbill, S.E. Plevy, R.L. Modlin, and S.T. Smale A prominent role for Spl during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages J. Immunol. 164 2000 1940 1951
7. J.H. Caamano, C.A. Rizzo, S.K. Durham, D.S. Barton, C. Raventos-Suarez, C.M. Snapper, and R. Bravo Nuclear factor (NF)-kB2 (pl00/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses J. Exp. Med. 187 1998 185 196
8. T. Christoph, R. Rickert, and K. Rajewsky M17: a novel gene expressed in germinal centers Int. Immunol. 6 1994 1203 1211
9. A.L. Dent, A.L. Shaffer, X. Yu, D. Allman, and L.M. Staudt Control of inflammation, cytokine expression, and germinal center formation by BCL-6 Science 276 1997 589 592
10. P. Ernst, and S.T. Smale Combinatorial regulation of transcription I: general aspects of transcriptional control Immunity 2 1995 311 319
11. U.K. Ewulonu, L. Ravi, and M.E. Medof Charcterization of the decay-accelerating factor gene promoter region Proc. Natl. Acad. Sci. U.S.A. 88 1991 4675 4679
12. D. Fitzsimmons, W. Hodsdon, W. Wheat, S.-M. Maira, B. Wasylyk, and J. Hagman Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter Genes Dev. 10 1996 2198 2211
13. G. Franzoso, L. Carlson, L. Poljak, E.W. Shores, S. Epstein, A. Leonardi, A. Grinberg, T. Tran, T. Scharton-Kersten, M. Anver, P. Love, K. Brown, and U. Siebenlist Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture J. Exp. Med. 187 1998 147 159
14. G. Franzoso, L. Carlson, T. Scharton-Kersten, E.W. Shores, S. Epstein, A. Grinberg, T. Tran, E. Shacter, A. Leonardi, M. Anver, P. Love, A. Sher, and U. Siebenlist Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions Immunity 6 1997 479 490
15. M. Husmann, P. Jehnichen, B. Jahn, D. Schlossman, E. Romahn, and J. Marx A novel SP-1 site in the human interleukin-1 b promoter confers preferential transcriptional activity in keratinocytes Eur. J. Immunol. 26 1996 3008 3014
16. H. Ihn, E. Carwile LeRoy, and M. Trojanowska Oncostatin M stimulates transcription of the human a2(I) collagen gene via the Spl/Sp3-binding site J. Biol. Chem. 272 1997 24666 24672
17. G. Keller, M. Kennedy, T. Papayannopoulou, and M. Wiles Hematopoietic commitment during embryonic stem cell differentiation in culture Mol. Cell. Biol. 13 1993 473 486
18. U. Kim, X.-F. Qin, S. Gong, S. Stevens, Y. Luo, M. Nussenzweig, and R.G. Roeder The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-l is essential for normal production of immunoglobulin isotypes Nature 383 1996 542 547
19. I.S. Lossos, A.A. Alizadeh, R. Rajapaksa, R. Tibshirani, and R. Levy HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma Blood 101 2003 433 440
20. M. Marin, A. Karis, P. Visser, F. Grosveld, and S. Philipsen Transcription factor Spl is essential for early embryonic development but dispensible for cell growth and differentiation Cell 89 1997 619 628
21. P.J. Nielsen, O. Georgiev, B. Lorenz, and W. Schaffner B lymphocytes are impaired in mice lacking the transcriptional coactivator Bobl/OCA-B/OBF-1 Eur. J. Immunol. 26 1996 3214 3218
22. Z. Pan, Y. Shen, C. Du, G. Zhou, A. Rosenwald, L.M. Staudt, T. Greiner, T.W. McKeithan, and W.C. Chan Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells Am. J. Pathol. 163 2003 135 144
23. M.W. Quong, D.P. Harris, S.L. Swain, and C. Murre E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination EMBO J. 18 1999 6307 6318
24. F. Rudert, E. Visser, L. Forbes, E. Lindridge, Y. Wang, and J. Watson Identification of a silencer, enhancer, and basal promoter region in the human CD95 (Fas/APO-1) gene DNA Cell Biol. 14 1995 931 937
25. D.B. Schubart, A. Rolink, M.H. Kosco-Vilbois, F. Botteri, and P. Matthias B-cell-specific coactivator OBF-1/OCA-B/Bob-l required for immune response and germinal center formation Nature 383 1996 538 542
26. E.M. Schwarz, P. Krimpenfort, A. Berns, and I.M. Verma Immunological defects in mice with a targeted disruption in Bcl-3 Genes Dev. 11 1997 187 197
27. H.T. Su, H.M. Chen, N. Muthusamy, L.A. Garrett-Sinha, D.G. Tenen, and M.C. Simon Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B EMBO J. 16 1997 7118 7129
28. P.F. van Loo, P. Bouwman, K.-W. Ling, S. Middendorp, G. Suske, F. Grosveld, E. Dzierzak, S. Philipsen, and R.W. Hendriks Impaired hematopoiesis in mice lacking the transcription factor Sp3 Blood 102 2003 858 866
29. G. Wright, B. Tan, A. Rosenwald, E.M. Hurt, A. Wiestner, and L.M. Staudt A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma Proc. Natl. Acad. Sci. U.S.A. 100 2003 9991 9996
30. B.H. Ye, G. Cattoretti, Q. Shen, J. Zhang, N. Hawe, R. de Waard, C. Leung, M. Nouri-Shirazi, A. Orazi, R.S. Chaganti, P. Rothman, A.M. Stall, P.P. Pandolfi, and R. Dalla-Favera The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation Nat. Genet. 16 1997 161 170