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Volumn 9, Issue 1, 2007, Pages 39-46

Alcoholic steatohepatitis: Management and prognosis

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALLOPURINOL; ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; BILIRUBIN; CORTICOSTEROID; DEFEROXAMINE; ETANERCEPT; INFLIXIMAB; MEDIUM CHAIN TRIACYLGLYCEROL; METHIONINE; METHYLPREDNISOLONE; PENTOXIFYLLINE; PLACEBO; PREDNISOLONE; S ADENOSYLMETHIONINE; SELENIUM;

EID: 33947672905     PISSN: 15228037     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11894-008-0019-6     Document Type: Review
Times cited : (6)

References (43)
  • 1
    • 0029941556 scopus 로고    scopus 로고
    • Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone
    • Mathurin P, Duchatelle V, Ramond MJ, et al.: Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone. Gastroenterology 1996, 110:1847-1853.
    • (1996) Gastroenterology , vol.110 , pp. 1847-1853
    • Mathurin, P.1    Duchatelle, V.2    Ramond, M.J.3
  • 2
    • 0026584313 scopus 로고
    • A randomized trial of prednisolone in patients with severe alcoholic hepatitis
    • Ramond MJ, Poynard T, Rueff B, et al.: A randomized trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med 1992, 326:507-512.
    • (1992) N Engl J Med , vol.326 , pp. 507-512
    • Ramond, M.J.1    Poynard, T.2    Rueff, B.3
  • 3
    • 33646471229 scopus 로고    scopus 로고
    • The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease
    • Thabut D, Naveau S, Charlotte F, et al.: The diagnostic value of biomarkers (AshTest) for the prediction of alcoholic steato-hepatitis in patients with chronic alcoholic liver disease. J Hepatol 2006, 44:1175-1185.
    • (2006) J Hepatol , vol.44 , pp. 1175-1185
    • Thabut, D.1    Naveau, S.2    Charlotte, F.3
  • 4
    • 0022993993 scopus 로고
    • The significance of clinically mild alcoholic hepatitis - Describing the population with minimal hyperbilirubinemia
    • VA Cooperative Study on Alcoholic Hepatitis. IV
    • Goldberg S, Mendenhall C, Anderson S, et al.: VA Cooperative Study on Alcoholic Hepatitis. IV. The significance of clinically mild alcoholic hepatitis - describing the population with minimal hyperbilirubinemia. Am J Gastroenterol 1986, 81:1029-1034.
    • (1986) Am J Gastroenterol , vol.81 , pp. 1029-1034
    • Goldberg, S.1    Mendenhall, C.2    Anderson, S.3
  • 6
    • 0024521973 scopus 로고
    • Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial
    • [see comments]
    • Carithers RL Jr, Herlong HF, Diehl AM, et al.: Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial [see comments]. Ann Intern Med 1989, 110:685-690.
    • (1989) Ann Intern Med , vol.110 , pp. 685-690
    • Carithers Jr., R.L.1    Herlong, H.F.2    Diehl, A.M.3
  • 7
    • 0034465251 scopus 로고    scopus 로고
    • Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial
    • Akriviadis E, Botla R, Briggs W, et al.: Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology 2000, 119:1637-1648.
    • (2000) Gastroenterology , vol.119 , pp. 1637-1648
    • Akriviadis, E.1    Botla, R.2    Briggs, W.3
  • 8
    • 22644432242 scopus 로고    scopus 로고
    • Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow Alcoholic Hepatitis Score
    • Forrest EH, Evans CD, Stewart S, et al.: Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow Alcoholic Hepatitis Score. Gut 2005, 54:1174-1179.
    • (2005) Gut , vol.54 , pp. 1174-1179
    • Forrest, E.H.1    Evans, C.D.2    Stewart, S.3
  • 9
    • 12844276509 scopus 로고    scopus 로고
    • MELD accurately predicts mortality in patients with alcoholic hepatitis
    • Dunn W, Jamil LH, Brown LS, et al.: MELD accurately predicts mortality in patients with alcoholic hepatitis. Hepatology 2005, 41:353-358.
    • (2005) Hepatology , vol.41 , pp. 353-358
    • Dunn, W.1    Jamil, L.H.2    Brown, L.S.3
  • 10
    • 4344715978 scopus 로고    scopus 로고
    • The role of the discriminant factor in the assessment and treatment of alcoholic hepatitis
    • Kulkarni K, Tran T, Medrano M, et al.: The role of the discriminant factor in the assessment and treatment of alcoholic hepatitis. J Clin Gastroenterol 2004, 38:453-459.
    • (2004) J Clin Gastroenterol , vol.38 , pp. 453-459
    • Kulkarni, K.1    Tran, T.2    Medrano, M.3
  • 11
    • 18744409852 scopus 로고    scopus 로고
    • Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis
    • Sheth M, Riggs M, Patel T.- Utility of the Mayo End-Stage Liver Disease (MELD) score in assessing prognosis of patients with alcoholic hepatitis. BMC Gastroenterol 2002, 2:2.
    • (2002) BMC Gastroenterol , vol.2 , pp. 2
    • Sheth, M.1    Riggs, M.2    Patel, T.3
  • 12
    • 17044398456 scopus 로고    scopus 로고
    • MELD score is a better prognostic model than Child-Turcotte-Pugh score or Discriminant Function score in patients with alcoholic hepatitis
    • Srikureja W, Kyulo NL, Runyon BA, Hu KQ: MELD score is a better prognostic model than Child-Turcotte-Pugh score or Discriminant Function score in patients with alcoholic hepatitis. J Hepatol 2005, 42:700-706.
    • (2005) J Hepatol , vol.42 , pp. 700-706
    • Srikureja, W.1    Kyulo, N.L.2    Runyon, B.A.3    Hu, K.Q.4
  • 13
    • 0021749036 scopus 로고
    • Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone
    • Mendenhall CL, Anderson S, Garcia-Pont P, et al.: Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. N Engl J Med 1984, 311:1464-1470.
    • (1984) N Engl J Med , vol.311 , pp. 1464-1470
    • Mendenhall, C.L.1    Anderson, S.2    Garcia-Pont, P.3
  • 14
    • 0036105350 scopus 로고    scopus 로고
    • Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): Individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH
    • Mathurin P, Mendenhall CL, Carithers RL, Jr., et al.: Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J Hepatol 2002, 36:480-487.
    • (2002) J Hepatol , vol.36 , pp. 480-487
    • Mathurin, P.1    Mendenhall, C.L.2    Carithers Jr., R.L.3
  • 15
    • 0029052203 scopus 로고
    • Glucocorticoids are ineffective in alcoholic hepatitis: A meta-analysis adjusting for confounding variables
    • [see comments]
    • Christensen E, Gluud C: Glucocorticoids are ineffective in alcoholic hepatitis: a meta-analysis adjusting for confounding variables [see comments]. Gut 1995, 37:113-118.
    • (1995) Gut , vol.37 , pp. 113-118
    • Christensen, E.1    Gluud, C.2
  • 16
    • 0025087535 scopus 로고
    • Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials
    • Imperiale TF, McCullough AJ: Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials. Ann Intern Med 1990, 113:299-307.
    • (1990) Ann Intern Med , vol.113 , pp. 299-307
    • Imperiale, T.F.1    McCullough, A.J.2
  • 17
    • 0032451389 scopus 로고    scopus 로고
    • Alcoholic liver disease: Proposed recommendations for the American College of Gastroenterology
    • McCullough AJ, O'Connor JF: Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am J Gastroenterol 1998, 93:2022-2036.
    • (1998) Am J Gastroenterol , vol.93 , pp. 2022-2036
    • McCullough, A.J.1    O'Connor, J.F.2
  • 18
    • 0242708668 scopus 로고    scopus 로고
    • Liver biopsy, viral kinetics, and the impact of viremia on severity of hepatitis C virus recurrence
    • Chariton M: Liver biopsy, viral kinetics, and the impact of viremia on severity of hepatitis C virus recurrence. Liver Transpl 2003, 9:S58-S62.
    • (2003) Liver Transpl , vol.9
    • Chariton, M.1
  • 19
    • 0033048585 scopus 로고    scopus 로고
    • Effects of corticosteroids on HCV infection
    • Magy N, Cribier B, Schmitt C, et al.: Effects of corticosteroids on HCV infection. Int J Immunopharmacol 1999, 21:253-261.
    • (1999) Int J Immunopharmacol , vol.21 , pp. 253-261
    • Magy, N.1    Cribier, B.2    Schmitt, C.3
  • 20
    • 32044431702 scopus 로고    scopus 로고
    • Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease
    • McClain C, Barve S, Joshi-Barve S, et al.: Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease. Alcohol Clin Exp Res 2005, 29:180S-188S.
    • (2005) Alcohol Clin Exp Res , vol.29
    • McClain, C.1    Barve, S.2    Joshi-Barve, S.3
  • 21
    • 0025278552 scopus 로고
    • Drugs that alter blood viscosity. Their role in therapy
    • Ehrly AM: Drugs that alter blood viscosity. Their role in therapy. Drugs 1990, 39:155-159.
    • (1990) Drugs , vol.39 , pp. 155-159
    • Ehrly, A.M.1
  • 22
    • 0028997545 scopus 로고
    • Relationship of protein calorie malnutrition to alcoholic liver disease: A reexammation of data from two Veterans AdnAmstration Cooperative Studies
    • Mendenhall C, Roselle GA, Gartside P, Moritz T: Relationship of protein calorie malnutrition to alcoholic liver disease: a reexammation of data from two Veterans AdnAmstration Cooperative Studies. Alcohol Clin Exp Res 1995, 19:635-641.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 635-641
    • Mendenhall, C.1    Roselle, G.A.2    Gartside, P.3    Moritz, T.4
  • 23
    • 33744531821 scopus 로고    scopus 로고
    • ESPEN Guidelines on enteral nutrition: Liver disease
    • Plauth M, Cabre E, Riggio O, et al.: ESPEN Guidelines on enteral nutrition: Liver disease. Clin Nutr 2006, 25:285-294.
    • (2006) Clin Nutr , vol.25 , pp. 285-294
    • Plauth, M.1    Cabre, E.2    Riggio, O.3
  • 24
    • 10344245582 scopus 로고    scopus 로고
    • Combining steroids with enteral nutrition: A better therapeutic strategy for severe alcoholic hepatitis? Results of a pilot study
    • Alvarez MA, Cabre E, Lorenzo-Zuniga V, et al.: Combining steroids with enteral nutrition: a better therapeutic strategy for severe alcoholic hepatitis? Results of a pilot study. Eur J Gastroenterol Hepatol 2004, 16:1375-1380.
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 1375-1380
    • Alvarez, M.A.1    Cabre, E.2    Lorenzo-Zuniga, V.3
  • 25
    • 0001835086 scopus 로고    scopus 로고
    • Short- and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: A multicenter randomized trial
    • Cabre E, Rodriguez-Iglesias P, Caballeria J, et al.: Short- and long-term outcome of severe alcohol-induced hepatitis treated with steroids or enteral nutrition: a multicenter randomized trial. Hepatology 2000, 32:36-42.
    • (2000) Hepatology , vol.32 , pp. 36-42
    • Cabre, E.1    Rodriguez-Iglesias, P.2    Caballeria, J.3
  • 26
    • 0034065782 scopus 로고    scopus 로고
    • Medium-chain triglycerides inhibit free radical formation and TNF-alpha production in rats given enteral ethanol
    • Kono H, Enomoto N, Connor HD, et al.: Medium-chain triglycerides inhibit free radical formation and TNF-alpha production in rats given enteral ethanol. Am J Physiol 2000, 278:G467-G476.
    • (2000) Am J Physiol , vol.278
    • Kono, H.1    Enomoto, N.2    Connor, H.D.3
  • 27
    • 0030426734 scopus 로고    scopus 로고
    • Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease
    • Nanji AA, Yang EK, Fogt F, et al.: Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease. J Pharmacol Exp Ther 1996, 277:1694-1700.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1694-1700
    • Nanji, A.A.1    Yang, E.K.2    Fogt, F.3
  • 28
    • 1442301516 scopus 로고    scopus 로고
    • A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis
    • Menon KV, Stadheim L, Kamath PS, et al.: A pilot study of the safety and tolerability of etanercept in patients with alcoholic hepatitis. Am J Gastroenterol 2004, 99:255-260.
    • (2004) Am J Gastroenterol , vol.99 , pp. 255-260
    • Menon, K.V.1    Stadheim, L.2    Kamath, P.S.3
  • 29
    • 0036784414 scopus 로고    scopus 로고
    • Combination of steroids with infliximalb or placebo in severe alcoholic hepatitis: A randomized controlled pilot study
    • Spahr L, Rubbia-Brandt L, Frossard JL, et al.: Combination of steroids with infliximalb or placebo in severe alcoholic hepatitis: a randomized controlled pilot study. J Hepatol 2002, 37:448-455.
    • (2002) J Hepatol , vol.37 , pp. 448-455
    • Spahr, L.1    Rubbia-Brandt, L.2    Frossard, J.L.3
  • 30
    • 0037386110 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    • Tilg H, Jalan R, Kaser A, et al.: Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. J Hepatol 2003, 38:419-425.
    • (2003) J Hepatol , vol.38 , pp. 419-425
    • Tilg, H.1    Jalan, R.2    Kaser, A.3
  • 31
    • 2342502025 scopus 로고    scopus 로고
    • A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis
    • Naveau S, Chollet-Martin S, Dharancy S, et al.: A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology 2004, 39:1390-1397.
    • (2004) Hepatology , vol.39 , pp. 1390-1397
    • Naveau, S.1    Chollet-Martin, S.2    Dharancy, S.3
  • 32
    • 23444450032 scopus 로고    scopus 로고
    • Corticosteroids for alcoholic hepatitis - What's next?
    • Mathurin P: Corticosteroids for alcoholic hepatitis - what's next? J Hepatol 2005, 43:526-533.
    • (2005) J Hepatol , vol.43 , pp. 526-533
    • Mathurin, P.1
  • 33
    • 33644882812 scopus 로고    scopus 로고
    • Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis - A randomised clinical trial
    • Phillips M, Curtis H, Portmann B, et al.: Antioxidants versus corticosteroids in the treatment of severe alcoholic hepatitis - a randomised clinical trial. J Hepatol 2006, 44:784-790.
    • (2006) J Hepatol , vol.44 , pp. 784-790
    • Phillips, M.1    Curtis, H.2    Portmann, B.3
  • 34
    • 0347950972 scopus 로고    scopus 로고
    • A randomized placebo controlled trial of vitamin E for alcoholic hepatitis
    • Mezey E, Potter JJ, Rennie-Tankersley L, et al.: A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. J Hepatol 2004, 40:40-46.
    • (2004) J Hepatol , vol.40 , pp. 40-46
    • Mezey, E.1    Potter, J.J.2    Rennie-Tankersley, L.3
  • 35
    • 0037230428 scopus 로고    scopus 로고
    • Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis
    • Jalan R, Sen S, Steiner C, et al.: Extracorporeal liver support with molecular adsorbents recirculating system in patients with severe acute alcoholic hepatitis. J Hepatol 2003, 38:24-31.
    • (2003) J Hepatol , vol.38 , pp. 24-31
    • Jalan, R.1    Sen, S.2    Steiner, C.3
  • 36
    • 34247550788 scopus 로고    scopus 로고
    • Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure
    • Laleman W, Wilmer A, Evenepoel P, et al.: Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure. Crit Care 2006, 10:R108.
    • (2006) Crit Care , vol.10
    • Laleman, W.1    Wilmer, A.2    Evenepoel, P.3
  • 37
    • 20444413736 scopus 로고    scopus 로고
    • Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis
    • Sen S, Mookerjee RP, Cheshire LM, et al.: Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis. J Hepatol 2005, 43:142-148.
    • (2005) J Hepatol , vol.43 , pp. 142-148
    • Sen, S.1    Mookerjee, R.P.2    Cheshire, L.M.3
  • 38
    • 33748616866 scopus 로고    scopus 로고
    • Prevalence of septic events, type 1 hepatorenal syndrome, and mortality in severe alcoholic hepatitis and utility of discriminant function and MELD score in predicting these adverse events
    • Verma S, Ajudia K, Mendler M, Redeker A: Prevalence of septic events, type 1 hepatorenal syndrome, and mortality in severe alcoholic hepatitis and utility of discriminant function and MELD score in predicting these adverse events. Dig Dis Sci 2006, 51:1637-1643.
    • (2006) Dig Dis Sci , vol.51 , pp. 1637-1643
    • Verma, S.1    Ajudia, K.2    Mendler, M.3    Redeker, A.4
  • 39
    • 0026023501 scopus 로고
    • Prognostic factors in alcoholic liver disease
    • VA Cooperative Study Group
    • Chedid A, Mendenhall CL, Gartside P, et al.: Prognostic factors in alcoholic liver disease. VA Cooperative Study Group. Am J Gastroenterol 1991, 86:210-216.
    • (1991) Am J Gastroenterol , vol.86 , pp. 210-216
    • Chedid, A.1    Mendenhall, C.L.2    Gartside, P.3
  • 40
    • 0023203440 scopus 로고
    • Prognosis of alcoholic cirrhosis in the presence and absence of alcoholic hepatitis
    • Orrego H, Blake JE, Blendis LM, Medline A: Prognosis of alcoholic cirrhosis in the presence and absence of alcoholic hepatitis. Gastroenterology 1987, 92:208-214.
    • (1987) Gastroenterology , vol.92 , pp. 208-214
    • Orrego, H.1    Blake, J.E.2    Blendis, L.M.3    Medline, A.4
  • 41
    • 0345448987 scopus 로고    scopus 로고
    • Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone
    • Mathurin P, Abdelnour M, Ramond MJ, et al.: Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone. Hepatology 2003, 38:1363-1369.
    • (2003) Hepatology , vol.38 , pp. 1363-1369
    • Mathurin, P.1    Abdelnour, M.2    Ramond, M.J.3
  • 42
    • 21244500924 scopus 로고    scopus 로고
    • Bilirubin response to corticosteroids in severe alcoholic hepatitis
    • Morris JM, Forrest EH: Bilirubin response to corticosteroids in severe alcoholic hepatitis. Eur J Gastroenterol Hepatol 2005, 17:759-762.
    • (2005) Eur J Gastroenterol Hepatol , vol.17 , pp. 759-762
    • Morris, J.M.1    Forrest, E.H.2
  • 43
    • 0344867846 scopus 로고    scopus 로고
    • S-adenosylmethionine in alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind, multicenter clinical trial
    • Mato JM, Camara J, Fernandez de Paz J, et al.: S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial. J Hepatol 1999, 30:1081-1089.
    • (1999) J Hepatol , vol.30 , pp. 1081-1089
    • Mato, J.M.1    Camara, J.2    Fernandez de Paz, J.3


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