Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure

Journal of Medicinal Chemistry

Volumn 50, Issue 6, 2007, Pages 1409-1413

  Dei, Silvia ^a   Bellucci, Cristina ^a   Buccioni, Michela ^b   Ferraroni, Marta ^a   Guandalini, Luca ^a   Manetti, Dina ^a   Martini, Elisabatta ^a   Marucci, Gabriella ^b   Matucci, Rosanna ^a   Nesi, Marta ^a   Romanelli, Maria Novella ^a   Scapecchi, Serena ^a   Teodori, Elisabetta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PYRROLIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; DIASTEREOISOMER; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; HUMAN; NONHUMAN; RABBIT; RECEPTOR AFFINITY; STEREOCHEMISTRY; VAS DEFERENS;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; GUINEA PIGS; HUMANS; ILEUM; MALE; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCARDIAL CONTRACTION; PYRROLIDINES; RABBITS; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; VAS DEFERENS;

EID: 33947657116     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061374r     Document Type: Article

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