A novel noninvasive method for assessing glutathione-conjugate efflux systems in the brain

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 9, 2007, Pages 3127-3133

  Okamura, Toshimitsu ^a   Kikuchi, Tatsuya ^a   Fukushi, Kiyoshi ^a   Arano, Yasushi ^b   Irie, Toshiaki ^a  

^a Molecular Imaging Center   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Active efflux transporter; Glutathione conjugate; Metabolite Extrusion Method; Purine analogues

Indexed keywords

6 CHLORO 7 METHYLPURINE C 11; 6 CHLORO 9 METHYLPURINE C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DESIGN; DRUG SYNTHESIS; ISOTOPE LABELING; NON INVASIVE MEASUREMENT; NONHUMAN; PHYSICAL CHEMISTRY; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; DRUG DESIGN; GLUTATHIONE; POSITRON-EMISSION TOMOGRAPHY; PURINES; RATS; RATS, WISTAR; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

RATTUS;

EID: 33947609734     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.045     Document Type: Article

References (20)

1. Kusuhara H., and Sugiyama Y. NeuroRx 2 (2005) 73
2. Lee G., Dallas S., Hong M., and Bendayan R. Pharmacol. Rev. 53 (2001) 569
3. Ghersi-Egea J.F., and Strazielle N. Microsc. Res. Tech. 52 (2001) 83
4. Deeley R.G., and Cole S.P. FEBS Lett. 580 (2006) 1103
5. Loscher W., and Potschka H. Prog. Neurobiol. 76 (2005) 22
6. Sultana R., and Butterfield D.A. Neurochem. Res. 29 (2004) 2215
7. Sun H., Miller D.W., and Elmquist W.F. Pharm. Res. 18 (2001) 1542
8. Sun H., Johnson D.R., Finch R.A., Sartorelli A.C., Miller D.W., and Elmquist W.F. Biochem. Biophys. Res. Commun. 284 (2001) 863
9. Sugiyama D., Kusuhara H., Lee Y.J., and Sugiyama Y. Pharm. Res. 20 (2003) 1394
10. Risberg J. Brain Lang. 9 (1980) 9
11. Olesen J., Paulson O.B., and Lassen N.A. Stroke 2 (1971) 519
12. Hwang I.Y., and Elfarra A.A. J. Pharmacol. Exp. Ther. 264 (1993) 41
13. Gerard-Monnier D., Fougeat S., and Chaudiere J. Biochem. Pharmacol. 43 (1992) 451
14. Johnson J.A., el Barbary A., Kornguth S.E., Brugge J.F., and Siegel F.L. J. Neurosci. 13 (1993) 2013
15. Montgomery J.A., and Temple Jr. C. J. Am. Chem. Soc. 83 (1961) 630
16. Irie T., Fukushi K., Namba H., Iyo M., Tamagami H., Nagatsuka S., and Ikota N. J. Nucl. Med. 37 (1996) 649
17. Hemmings S.J., and Storey K.B. Mol. Cell Biochem. 202 (1999) 119
18. Robins R.K., and Lin H.H. J. Am. Chem. Soc. 79 (1957) 490
19. Prasad R.N., and Robins R.K. J. Am. Chem. Soc. 79 (1957) 6401
20. Hwang I.Y., and Elfarra A.A. J. Pharmacol. Exp. Ther. 258 (1991) 171