Amphiphilic polyether branched molecules to increase the circulation time of cationic particles

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 9, 2007, Pages 3176-3186

  Garinot, Marie ^a,b,c,d   Mignet, Nathalie ^a,b,c,d   Largeau, Celine ^a,b,c,d   Seguin, Johanne ^a,b,c,d   Scherman, Daniel ^a,b,c,d   Bessodes, Michel ^a,b,c,d  

^a INSERM   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d PSL RESEARCH UNIVERSITY   (France)

Author keywords

Biological properties; Blood circulation time enhancement; Inhibition of nonspecific interactions; Liposome DNA complexes; Neutral amphiphilic lipid; Physical chemistry; Surface charge shielding; Synthesis

Indexed keywords

2 AMINO N [(DIOCTADECYLCARBAMOYLMETHYLCARBAMOYL)METHYL]ACETAMIDE; 3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXYMETHYL)PROPANE; 3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXYMETHYL)PROPENE; 3 [3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXYMETHYL)PROPOXY] 2 [3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXYMETHYL)PROPOXYMETHYL]PROPANOL; 3 [3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXYMETHYL)PROPOXY] 2 [3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXYMETHYL)PROPOXYMETHYL]PROPENE; [[[(DIOCTADECYLCARBAMOYLMETHYLCARBAMOYL)METHYL]CARBAMOYL]METHYL]CARBAMIC ACID 3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (1 ENZYLOXYMETHYL 2 BENZYLOXYETHOXYMETHYL)PROPYLESTER; [[[(DIOCTADECYLCARBAMOYLMETHYLCARBAMOYL)METHYL]CARBAMOYL]METHYL]CARBAMIC ACID 3 (2 HYDROXY 1 HYDROXYMETHYLETHOXY) 2 (2 HYDROXY 1 HYDROXYMETHYLETHOXYMETHYL)PROPYL ESTER; [[[(DIOCTADECYLCARBAMOYLMETHYLCARBAMOYL)METHYL]CARBAMOYL]METHYL]CARBAMIC ACID TERT BUTYL ESTER; AMPHOPHILE; DIOCTADECYLCARBAMIC ACID 3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (1 BENZYLOXYMETHYL 2 BENZYLOXYETHOXYMETHYL)PROPYL ESTER; DIOCTADECYLCARBAMIC ACID 3 (2 HYDROXY 1 HYDROXYMETHYLETHOXY) 2 (2 HYDROXY 1 HYDROXYMETHYLETHOXYMETHYL)PROPYL ESTER; DIOCTADECYLCARBAMIC ACID 3 [3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (1 BENZYLOXYMETHYL 2 HYDROXYETHOXYMETHYL)PROPOXY] 2 [3 (2 BENZYLOXY 1 BENZYLOXYMETHYLETHOXY) 2 (1 BENZYLOXYMETHYL 2 HYDROXYETHOXYMETHYL)PROPOXYMETHYL]PROPYL ESTER; DIOCTADECYLCARBAMIC ACID 3 [3 (2 HYDROXY 1 HYDROXYMETHYLETHOXY) 2 (2 HYDROXY 1 HYDROXYMETHYLETHOXYMETHYL)PROPOXY] 2 [3 (2 HYDROXY 1 HYDROXYMETHYLETHOXY) 2 (2 HYDROXY 1 HYDROXYMETHYLETHOXYMETHYL)PROPOXYMETHYL]PROPYL ESTER; DNA; LIPOPLEX; LIPOSOME; MACROGOL; POLYETHER DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD COMPONENT; CIRCULATION TIME; DRUG FORMULATION; DRUG SYNTHESIS; FEMALE; LIPOSOMAL GENE DELIVERY SYSTEM; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; STATISTICAL SIGNIFICANCE;

ANIMALS; BLOOD CIRCULATION TIME; CATIONS; CELL LINE, TUMOR; DNA; DRUG STABILITY; ETHERS; FEMALE; LIPOSOMES; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PARTICLE SIZE; POLYMERS; SURFACE PROPERTIES; TIME FACTORS; TRANSFECTION;

EID: 33947607370     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.037     Document Type: Article

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