First synthesis of 7α- and 7β-amino-DHEA, dehydroepiandrosterone (DHEA) analogues and preliminary evaluation of their cytotoxicity on Leydig cells and TM4 Sertoli cells

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 9, 2007, Pages 3152-3160

  Bazin, Marc Antoine ^a   Travert, Carine ^b   Carreau, Serge ^b   Rault, Sylvain ^a   Kihel, Laïla El ^a  

^a CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

^b UNIVERSITÉ DE CAEN   (France)

Author keywords

Aminosteroids; Cytotoxicity; DHEA; DHEA analogues; Hormones; TM4 cells

Indexed keywords

7ALPHA AMINO 3BETA HYDROXYANDROST 5 EN 17 ONE; 7ALPHA,BETA AMINO 3BETA HYDROXYANDROST 5 ENE; 7BETA AMINO 3BETA HYDROXYANDROST 5 EN 17 ONE; AZIDE; BROMINE DERIVATIVE; PRASTERONE; UNCLASSIFIED DRUG; 7ALPHA AMINO DEHYDROEPIANDROSTERONE; 7ALPHA-AMINO-DEHYDROEPIANDROSTERONE; DRUG DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BROMINATION; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; LEYDIG CELL; MALE; MOUSE; NONHUMAN; RAT; SERTOLI CELL; SUBSTITUTION REACTION; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECT; SPRAGUE DAWLEY RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DEHYDROEPIANDROSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; LEYDIG CELLS; MALE; MOLECULAR CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; SERTOLI CELLS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947575765     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.036     Document Type: Article

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