DPIV prediction of flow induced platelet activation-comparison to numerical predictions

Annals of Biomedical Engineering

Volumn 35, Issue 4, 2007, Pages 493-504

  Raz, Sagi ^a   Einav, Shmuel ^a   Alemu, Yared ^b   Bluestein, Danny ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b St Francis Hospital The Heart Center   (United States)

Author keywords

Blood flow; CFD; DPIV; Platelet activation; Shear stress

Indexed keywords

BLOOD VESSELS; COMPUTATIONAL FLUID DYNAMICS; LAGRANGE MULTIPLIERS; NUMERICAL METHODS; SHEAR STRESS; VELOCITY MEASUREMENT;

DIGITAL PARTICLE IMAGE VELOCIMETRY (DPIV); PLATELET ACTIVATION (PA); UNIDIRECTIONAL FLOW CONDITIONS;

PLATELETS;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BLOOD FLOW VELOCITY; BLOOD RHEOLOGY; COMPARATIVE STUDY; CORONARY ARTERY OBSTRUCTION; HUMAN; MECHANICAL STRESS; PATHOPHYSIOLOGY; THROMBOCYTE; THROMBOCYTE ACTIVATION;

ANIMALS; BLOOD FLOW VELOCITY; BLOOD PLATELETS; CORONARY STENOSIS; HEMORHEOLOGY; HUMANS; MODELS, CARDIOVASCULAR; PLATELET ACTIVATION; STRESS, MECHANICAL;

EID: 33947428824     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-007-9257-2     Document Type: Article

References (20)

1. Apel, J., R. Paul, S. Klaus, T. Siess, and H. Reul. Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics. Artif Org 25(5):341-347, 2001.
2. Barstad, R. M., P. Kierulf, and K. S. Sakariassen. Collagen induced thrombus formation at the apex of eccentric stenoses-a time course study with non-anticoagulated human blood. Thromb Haemost 75(4):685-692, 1996.
3. Bluestein, D., L. Niu, R. T. Schoephoerster, and M. K. Dewanjee. Fluid mechanics of arterial stenosis: relationship to the development of mural thrombus. Ann Biomed Eng 25(2);344-356, 1997.
4. Bluestein, D., C. Gutierrez, M. Londono, and R. T. Schoephoerster. Vortex shedding in steady flow through a model of an arterial stenosis and its relevance to mural platelet deposition. Ann Biomed Eng 27(6):763-773, 1999.
5. Bluestein, D., E. Rambod, and M. Gharib. Vortex shedding as a mechanism for free emboli formation in mechanical heart valves. J Biomech Eng 122(2): 125-134, 2000.
6. Bluestein D., and S. Einav. Techniques in the analysis of stability of pulsatile flow through heart valves. In: Biomechanics Systems Techniques and Applications: Cardiovascular Techniques, edited by C. T. Leondes. Boca Raton, FL: CRC Press LLC, 2001, pp. 4-1:4-39.
7. Bluestein, D. and S. Einav. Transition to turbulence in pulsatile flow through heart valves-a modified stability approach. J Biomech Eng 116(4):477-487, 1994.
8. Boreda, R, R. S. Fatemi, and S. E. Rittgers. Potential for platelet stimulation in critically stenosed carotid and coronary arteries. J Vase Invest 1:26-37, 1995.
9. Cao, J. and S. E. Rittgers. Particle motion within in vitro models of stenosed internal carotid and left anterior descending coronary arteries. Ann Biomed Eng 26(2): 190-199, 1998.
10. Glantz, S. A. Primer of Biostatistics (4th ed.). McGraw-Hill, New York.
11. Gosman, A. D., and E. Ioannides. Aspects of computer simulation of liquid-fueled combustors. J. Energy 7(6):482-490, 1983.
12. Hellums J. D., D. M. Peterson, N. A. Stathopoulos, J. L. Moake, and T. D. Giorgio. Studies on the mechanisms of shear-induced platelet activation. In: Cerebral Ischemia and Hemorheology, edited by A. Hartman, and W. Kuschinsky. New York: Springer and Verlag, 1987, pp. 80-89.
13. Holton, A. D., E. G. Walsh, B. C. Brott, R. Venugopalan, B. Hershey, Y. Ito, A. Shih, R. Koomullil, and A. S. Anayiotos. Evaluation of in-stent stenosis by magnetic resonance phase-velocity mapping in nickel-titanium stents. J Magn Reson Imaging 22(2):248-257, 2005.
14. Jesty J., and Y. Nemerson. The pathways of blood coagulation. In: Williams Hematology, 5th ed., edited by E. Beutler, M. A. L., B.S. Coller, and T.J. Kipps. New York: McGraw-Hill, 1995, pp. 1227-1238.
15. Jesty, J., W. Yin, P. Perrotta, and D. Bluestein. Platelet activation in a circulating flow loop: combined effects of shear stress and exposure time. Platelets 14(3): 143-149, 2003.
16. Jesty, J. and D. Bluestein. Acetylated prothrombin as a substrate in the measurement of the procoagulant activity of platelets: Elimination of the feedback activation of platelets by thrombin. Anal Biochem 272(1):64-70, 1999.
17. Merrill, E. W., E. R. Gilliland, G. Cokelet, H. Shin, A. Britten, and R. E. Wells. Rheology of human blood, near and at zero flow. Biophys. J. 3:199-213, 1963.
18. Steinman, D. A., Simulated pathline visualization of computed periodic blood flow patterns. J Biomech 33(5):623-628, 2000.
19. Sukavaneshvar, S., Y. Zheng, G. M. Rosa, S. F. Mohammad, and K. A. Solen. Thromboembolization associated with sudden increases in flow in a coronary stent ex vivo shunt model. Asaio J 46(3):301-304, 2000.
20. Willert,. Digital particle image velocimetry. Exp Fluids 10(4): 181-193, 1991.