Platelet activation in a circulating flow loop: Combined effects of shear stress and exposure time

Platelets

Volumn 14, Issue 3, 2003, Pages 143-149

  Jesty, Jolyon ^a,c   Yin, Wei ^b   Perrotta, Peter ^a   Bluestein, Danny ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b St Francis Hospital The Heart Center   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; PROTHROMBIN; THROMBIN;

ARTICLE; BLOOD FLOW VELOCITY; CHEMICAL MODIFICATION; CIRCULATION; CIRCULATION TIME; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SHEAR STRESS; SIMULATION; THROMBOCYTE ACTIVATION; VISCOSITY;

BLOOD CIRCULATION; BLOOD COAGULATION TESTS; BLOOD VISCOSITY; CORONARY STENOSIS; HEMORHEOLOGY; HUMANS; MODELS, CARDIOVASCULAR; PLATELET ACTIVATION; STRESS, MECHANICAL; TIME FACTORS;

EID: 0038627711     PISSN: 09537104     EISSN: None     Source Type: Journal    
DOI: 10.1080/0953710031000092839     Document Type: Article

References (20)

1. Delouphery T. Atherosclerosis: Overview. New Engl J Med 1992; 326: 1406.
2. Wootton D M, Ku D N. Fluid mechanics of vascular systems, diseases, and thrombosis. Annu Rev Biomed Eng 1999; 1: 299-329.
3. Folts J D, Crowell E B, Rowe G G. Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 1976; 54: 365-70.
4. Folts J D, Gallhager K P, Rowe G G. Hemodynamic effects of controlled degrees of coronary artery stenosis in short-term and long-term studies in dogs. J Thorac Cardiovasc Surg 1977; 73: 722-7.
5. Folts J D, Gallhager K P, Rowe G G. Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? Circulation 1982; 65: 249-55.
6. Strony J, Beaudoin A, Brands D, et al. Analysis of shear stress and hemodynamic factors in a model of artery stenosis and thrombosis. Am J Physiol 1993; 265: 1787-96.
7. Bluestein D, Niu L, Schoephoerster R T, et al. Fluid mechanics of flow through a stenosis: relationship to the development of mural thrombus. Ann Biomed Eng 1997; 25: 344-56.
8. Bluestein D, Gutierrez C, Londono M, et al. Vortex shedding in arterial stenosis and its relevance to mural platelet deposition. Ann Biomed Eng 1999; 27: 763-73.
9. Ramstack J M, Zuckerman L, Mockros L F. Shear induced activation of platelets. J Biomechanics 1979; 12: 113-25.
10. Hellums J D, Peterson D M, Stathopoulos N A, et al. Studies on the mechanisms of shear-induced platelet activation. In: Hartman A, Kushinsky W, eds. Cerebral Ischemia and Hemorheology, New York, NY: Springer, 1987; 80.
11. Sutera S P, Nowak M D, Joist J H, et al. A programmable, computer-controlled, cone-plate viscometer for the application of pulsatile shear stress to platelet suspensions. Biorheology 1988; 25: 449-59.
12. Purvis N B, Giorgio T D. The effect of elongational stress exposure on the activation and aggregation of blood platelets. Biorheology 1991; 28: 355-67.
13. Boreda R, Tatemi R S, Rittgers S E. Potential for platelet stimulation in critically stenosed carotid and coronary arteries. J Vasc Invest 1995; 1: 26-37.
14. Neuenschwander P, Jesty J. A comparison of phospholipid and platelets in the activation of human factor VIII by thrombin and factor Xa, and in the activation of factor X. Blood 1988; 76: 1761-70.
15. Jesty J, Bluestein D. Acetylated prothrombin as a substrate in the measurement of the procoagulant activity of platelets: elimination of the feedback activation of platelets by thrombin. Anal Biochem. 1999; 272: 64-70.
16. Glantz S A. A Primer of Biostatistics, 4th edition. New York: McGraw-Hill, 1997.
17. Shoenfeld N A, Eldrup-Jorgensen J, Connolly R, et al. The effect of low molecular weight dextran on platelet deposition onto prosthetic materials. J Vasc Surg 1987; 5: 76-82.
18. Garrett K O, Pautler S V, Johnson P C. The inability of low-molecular-weight dextran, aspirin, and prostaglandin E1 to inhibit monolayer platelet adhesion to polyethylene. J Lab Clin Med 1993; 122: 141-8.
19. Kroll M H, Hellums J D, McIntire L V, et al. Platelets and shear stress. Blood 1996; 88: 1525-41.
20. Merten M, Chow T, Hellums J D, et al. A new role for P-selectin in shear-induced platelet aggregation. Circulation 2000; 102: 2045-50.