Sheet Preparations Expose the Dermal Nerve Plexus of Human Skin and Render the Dermal Nerve End Organ Accessible to Extensive Analysis

Journal of Investigative Dermatology

Volumn 122, Issue 1, 2004, Pages 177-182

  Tschachler, Erwin ^a,b   Reinisch, Christina M ^a   Mayer, Christoph ^a   Paiha, Karin ^c   Lassmann, Hans ^d   Weninger, Wolfgang ^a,e  

^a Universitatsklinik fur Dermatologie   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^d Centre de Recherches et d'Investigations   (France)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Nerve endings; Schwann cell; Sensory end organ; Skin nerves

Indexed keywords

CD56 ANTIGEN; NERVE CELL ADHESION MOLECULE;

CONTROLLED STUDY; ELECTRON MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER MICROSCOPY; METHODOLOGY; MICROMORPHOLOGY; MICROSCOPY; NERVE CELL NETWORK; NERVE ENDING; NERVE FIBER; NERVE PLEXUS; PRIORITY JOURNAL; REVIEW; SCHWANN CELL; SKIN CULTURE; TISSUE SECTION;

EID: 1642493784     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2003.22102.x     Document Type: Article

References (29)

1. Arthur RP, Shelley WB: The innervation of human epidermis. J Invest Dermatol 32:397-411, 1959
2. Bourlond A: L'Innervation Cutanée. Paris: Masson, 1968
3. Breathnach AS: Electron microscopy of cutaneous nerves and receptors. J Invest Dermatol 69:8-26, 1977
4. Bukh A, Ingerslev J, Stenbjerg S, Moller NPH: The multimeric structure of plasma F VIII. Rag studied by electroelution and immunoperoxidase detection. Thromb Res 43:579-584, 1986
5. Cauna N: The free penicillate nerve endings of the human hairy skin. J Anat 115:277-288, 1973
6. Daalsgard CJ, Rydh M, Haegerstrand A: Cutaneous innervation in man visualized with protein gene product 9.5 (PGP9.5) antibodies. Histochemistry 92:385-390, 1989
7. Griffin JW, McArthur JC, Polydefkis M: Assessment of cutaneous innervation by skin biopsies. Curr Opin Neurol 14:655-659, 2001
8. Guinard D, Usson Y, Guillermet C, Saxod R: Merkel complexes of human digital skin: Three-dimensional imaging with confocal laser microscopy and double immunofluorescence. J Comp Neurol 398:98-104, 1998
9. Haimanot RT, Melaku Z: Leprosy. Curr Opin Neurol 13:317-322, 2000
10. Hilliges M, Wang L, Johansson O: Ultrastructural evidence for nerve fibers within all vital layers of the human epidermis. J Invest Dermatol 104:134-137, 1995
11. Johansson O, Han SW, Enhamre A: Altered cutaneous innervation in psoriatic skin as revealed by PGP 9.5 immunohistochemstry. Arch Dermatol Res 283:519-523, 1991
12. Johansson O, Wang L, Hilliges M, Liang Y: Intraepidermal nerves in human skin: PgP9.5 immunohistochemistry with special reference to the nerve density in skin from different body regions. J Peripher Nerv Syst 4:43-52, 1999
13. Juhlin L, Shelley WB: New staining techniques for the Langerhans cell. Acta Derm Venereol 57:289-296, 1977
14. Kennedy WR, Nolano M, Wendelschafer-Crabb G, Johnson TL, Tamura E: The skin blister method to study epidermal nerves in peripheral nerve disease. Muscle Nerve 22:360-371, 1999
15. Kennedy WR, Wendelschafer-Crabb G, Brelic TC: Innervation and vasculature of human sweat glands: An immunohistochemistry-laser scanning confocal fluorescence microscopy study. J Neurosci 14:6825-6833, 1994
16. Kennedy WR, Wendelschafer-Crabb G, Johnson T: Quantitation of epidermal nerves in diabetic neuropathy. Neurology 47:1042-1048, 1996
17. Kitano Y, Okada N: Separation of the epidermal sheet by dispase. Br J Dermatol 108:555-560, 1983
18. Lauria G: Innervation of the human epidermis: A historical overview. Ital J Neurol Sci 20:63-70, 1999
19. Le Forestier N, Lescs MC, Gherardi RK: Anti-NKH-1 antibody specifically stains unmyelinated fibres and non-myelinating Schwann cell columns in humans. Neuropathol Appl Neurobiol 19:500-506, 1993
20. McCarthy BG, Hsieh ST, Stocks A, et al: Cutaneous innervation in sensory neuropathies, Evaluation by skin biopsy. Neurology 45:1848-1855, 1995
21. Orfanos CE, Mahrle G: Ultrastucture and cytochemistry of human cutaneous nerves. J Invest Dermatol 61:108-120, 1973
22. Stewart JD, Low PA: Small-fiber neuropathy. In: Low PA (eds). Clinical Autonomic Disorders: Evaluation and Management. Boston: Little, Brown, 1993; p 653-666
23. Sugiura H, Omoto M, Hirota Y, Danno K, Uehara M: Density and fine structure of peripheral nerves in various skin lesions of atopic dermatitis. Arch Dermatol Res 289:125-131, 1997
24. Vass K, Lassmann H, Wekerle H, Wisniewski HM: The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis. Acta Neuropathol (Berlin) 70:149-160, 1986
25. Wang L, Hilliges M, Jernberg T, Wieberg-Edstrom D, Johansson O: Protein gene product 9.5-immunoreactive nerve fibers and cell in human skin. Cell Tissue Res 261:25-33, 1990
26. Weddell G: The anatomy of cutaneous sensibility. Br Med Bull 3:167-172, 1945
27. Weninger W, Partanen TA, Breiteneder-Geleff S, et al: Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells. Lab Invest 79:243-251, 1999
28. Winkelmann RK: Similarities in cutaneous nerve end-organs. In: Montagna W (eds). Advances in Biology of Skin, Vol. 1. Oxford/London/New York/Paris: Pergamon Press, 1960; p 48-62
29. Winkelmann RK, Wolff K, Pierce J: Removal of epidermis with sodium bromide for cholinesterase staining of dermal nerves. Stain Technol 42:214-215, 1967