Mutations that decrease DNA binding of the processivity factor of the herpes simplex virus DNA polymerase reduce viral yield, alter the kinetics of viral DNA replication, and decrease the fidelity of DNA replication

Journal of Virology

Volumn 81, Issue 7, 2007, Pages 3495-3502

  Jiang, Changying ^a   Hwang, Ying T ^a   Randell, John C W ^b,c   Coen, Donald M ^b   Hwang, Charles B C ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DNA POLYMERASE; MEMBRANE PROTEIN; PLASMID DNA; PROTEIN UL42; UNCLASSIFIED DRUG; VIRUS DNA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; DISEASE ASSOCIATION; DNA BINDING; DNA REPLICATION; DNA SYNTHESIS; GENE CONSTRUCT; GENETIC COMPLEMENTATION; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 1; KINETICS; MAMMAL CELL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; VIROGENESIS; VIRUS GENOME; VIRUS MUTANT; VIRUS REPLICATION;

ANIMALS; CERCOPITHECUS AETHIOPS; DNA REPLICATION; DNA, RECOMBINANT; DNA, VIRAL; DNA-DIRECTED DNA POLYMERASE; EXODEOXYRIBONUCLEASES; HERPESVIRUS 1, HUMAN; KINETICS; LAC OPERON; MUTATION; VERO CELLS; VIRAL PROTEINS;

HUMAN HERPESVIRUS 1; MAMMALIA; SIMPLEXVIRUS;

EID: 33947420068     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02359-06     Document Type: Article

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