Effects of exonuclease activity and nucleotide selectivity of the herpes simplex virus DNA polymerase on the fidelity of DNA replication in vivo

Journal of Virology

Volumn 73, Issue 7, 1999, Pages 5326-5332

  Hwang, Ying T ^a   Liu, Bu Yuan ^a,b   Hong, Chi Yuan ^b   Shillitoe, Edward J ^a   Hwang, Charles B C ^a  

^a SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; EXONUCLEASE; MUTANT PROTEIN; THYMIDINE KINASE; VIRUS DNA;

ANIMAL CELL; ARTICLE; BASE PAIRING; CONTROLLED STUDY; DNA REPLICATION; ENZYME ACTIVITY; ENZYME ASSAY; HERPES SIMPLEX VIRUS 1; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; VIRUS GENE; VIRUS MUTANT; VIRUS MUTATION;

EID: 0032989101     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.7.5326-5332.1999     Document Type: Article

References (30)

1. Abbotts, J., K. Bebenek, T. A. Kunkel, and S. H. Wilson. 1993. Mechanism of HIV-1 reverse transcriptase. Termination of processive synthesis on a natural DNA template is influenced by the sequence of the template-primer stem. J. Biol. Chem. 268:10312-10323.
2. Carroll, S. S., M. Cowart, and S. J. Benkovic. 1991. A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity. Biochemistry 30:804-813.
3. Challberg, M. D. 1986. A method for identifying the viral genes required for herpesvirus DNA replication. Proc. Natl. Acad. Sci. USA 83:9094-9098.
4. Challberg, M. D. 1996. Herpesvirus DNA replication, p. 721-750. In M. L. DePamphilis (ed.), DNA replication in eukaryotic cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
5. Clarke, G. M. 1994. Statistics and experimental design. An introduction for biologists and biochemists, 3rd ed., p. 82-83. Edward Arnold, London, England.
6. Clarks, P., and J. B. Clements. 1991. Mutagenesis occurring following infection with herpes simplex virus does not require virus replication. Virology 182:597-606.
7. Coen, D. M. 1996. Viral DNA polymerases, p. 495-523. In M. L. DePamphilis (ed.), DNA replication in eukaryotic cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
8. Coen, D. M., P. A. Furman, D. P. Aschman, and P. A. Schaffer. 1983. Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin. Nucleic Acids Res. 11:5287-5297.
9. Fisher, L. D., and G. van Belle. 1993. Biostatistics - a methodology for the health sciences, p. 218-221. John Wiley & Sons, Inc., New York, N.Y.
10. Gibbs, J. S., H. C. Chiou, K. F. Bastow, Y. C. Cheng, and D. M. Coen. 1988. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Proc. Natl. Acad. Sci. USA 85: 6672-6676.
11. Goodman, M. F., S. Creighton, L. B. Bloom, and J. Petruska. 1993. Biochemical basis of DNA replication fidelity. Crit. Rev. Biochem. Mol. Biol. 28:83-126.
12. Hall, J. D., D. M. Coen, B. L. Fisher, M. Weisslitz, S. Randall, R. E. Almy, P. Gelep, and P. A. Schaffer. 1984. Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. Virology 132:26-37.
13. Hall, J. D., P. A. Furman, M. H. St. Clair, and C. W. Knopf. 1985. Reduced in vivo mutagenesis by mutant herpes simplex DNA polymerase involves improved nucleotide selection. Proc. Natl. Acad. Sci. USA 82:3889-3893.
14. Hauser, J., M. M. Seidman, K. Sidur, and K. Dixon. 1986. Sequence specificity of point mutations induced during passage of a UV-irradiated shuttle vector plasmid in monkey cells. Mol. Cell. Biol. 6:277-285.
15. Hwang, C. B. C., and J.-H. Chen. 1995. Altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase. Gene 152: 191-193.
16. Hwang, C. B. C., and E. J. Shillitoe. 1990. DNA sequence of mutations induced in cells by herpes simplex virus type-1. Virology 178:180-188.
17. Hwang, Y. T., and C. B. C. Hwang. Unpublished data.
18. Hwang, Y. T., B.-Y. Liu, D. M. Coen, and C. B. C. Hwang. 1997. Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity. J. Virol. 71:7791-7798.
19. Jamieson, A. T., and G. Bjursell. 1976. Deoxyribonucleotide triphosphate pools in herpes simplex virus type 1 infected cells. J. Gen. Virol. 31:101-113.
20. Kunkel, T. A., and P. S. Alexander. 1986. The base substitution fidelity of eucaryotic DNA polymerases. Mispairing frequencies, site preferences, insertion preferences, and base substitutions by dislocation. J. Biol. Chem. 261:160-166.
21. Marcy, A. I., D. R. Yager, and D. M. Coen. 1990. Isolation and characterization of herpes simplex virus mutants containing engineered mutations at the DNA polymerase locus. J. Virol. 64:2208-2216.
22. Parris, C. N., and M. M. Seidman. 1992. A signature element distinguishes sibling and independent mutations in a shuttle vector plasmid. Gene 117:1-5.
23. Peden, K. W. C., J. M. Ripas, S. Pearson-White, and D. Nathans. 1980. Isolation of mutants of an animal virus in bacteria. Science 209:1392-1396.
24. Roberts, J. D., and T. A. Kunkel. 1996. Eukaryotic DNA replication fidelity, p. 217-247. In M. L. DePamphilis (ed.), DNA replication in eukaryotic cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
25. Sal Giannino, D., G. Manfioletti, and C. Schneider. 1989. The CTAB-DNA precipitation method: a common mini-scale precipitation of template DNA from phagemid, phages or plasmids suitable for sequencing. Bio/Technology 7:514-519.
26. Seidman, M. M., A. Bregberg, S. Seetharam, and K. H. Kraemer. 1987. Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity. Proc. Natl. Acad. Sci. USA 84:4944-4948.
27. Seidman, M. M., K. Dixon, A. Razzaque, R. J. Zagursky, and M. L. Berman. 1985. A shuttle vector plasmid for studying carcinogen-induced point mutations in mammalian cells. Gene 38:233-237.
28. Shillitoe, E. J., S. Zhang, G. Wang, and C. B. C. Hwang. 1993. Functions and proteins of herpes simplex virus type-1 that are involved in raising the mutation frequency of infected cells. Virus Res. 27:239-251.
29. Topal, M. D., and J. R. Fresco. 1976. Base pairing and fidelity in codonanticodon interaction. Nature 263:285-289.
30. Wong, S. W., and P. A. Schaffer. 1991. Elements in the transcriptional regulatory region flanking herpes simplex virus type 1 oriS stimulate origin function. J. Virol. 65:2601-2611.