The role of statins in erectile dysfunction

Drugs of Today

Volumn 43, Issue 1, 2007, Pages 55-59

  Ferrer, Elisa ^a   Moral, Maria Àngels ^a   Bozzo, Jordi ^a  

^a Medical Information Department   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; RHO KINASE; SILDENAFIL;

ADJUVANT THERAPY; CARDIOVASCULAR DISEASE; CLINICAL FEATURE; CLINICAL RESEARCH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG MECHANISM; DRUG POTENTIATION; ENZYME INHIBITION; ERECTILE DYSFUNCTION; HUMAN; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; REVIEW; SEXUAL AROUSAL; VASCULAR DISEASE; VASCULAR ENDOTHELIUM;

CARDIOVASCULAR DISEASES; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMPOTENCE; MALE; PENILE ERECTION; PHOSPHODIESTERASE INHIBITORS;

EID: 33947390476     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2007.43.1.1062672     Document Type: Review

References (21)

1. Dean, R.C., Lue, T.F. Physiology of penile erection and pathophysiology of erectile dysfunction. Urol Clin North Am 2005, 32: 379-95.
2. Chitaley, K., Webb, R.C., Mills, T.M., Rho-kinase as a potential target for the treatment of erectile dysfunction. Drug News Perspect 2001, 14: 601-6.
3. Kolodny, L. Erectile dysfunction and vascular disease. What is the connection? Postgrad Med 2003, 114: 30-40.
4. Billups, K.L. Erectile dysfunction as an early sign of cardiovascular disease. Int J Impot Res 2005, 17 (Suppl. 1): S19-24.
5. Blumentals, W.A., Gomez-Caminero, A., Joo, S., Vannappagari, V. Should erectile dysfunction be considered as a marker for acute myocardial infarction? Results from a retrospective cohort study. Int J Impot Res 2004, 16: 350-3.
6. Blumentals, W.A., Gomez-Caminero, A., Joo, S., Vannappagari, V. Is erectile dysfunction predictive of peripheral vascular disease? Aging Male 2003, 6: 217-21.
7. Elrod, J.W., Lefer, D.J. The effects of statins on endothelium, inflammation and cardioprotection. Drug News Perspect 2005, 18: 229-36.
8. Rikitake, Y., Liao, J.K. Rho GTPases, statins, and nitric oxide. Circ Res 2005, 97: 1232-5.
9. Harris, M.B., Blackstone, M.A., Sood, S.G. et al. Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors. Am J Physiol Heart Circ Physiol 2004, 287: H560-6.
10. Laufs, U., Endres, M., Custodis, F. et al. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription. Circulation 2000, 102: 3104-10.
11. Takemoto, M., Sun, J., Hiroki, J., Shimokawa, H., Liao, J.K. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 2002, 106: 57-62.
12. Nishimatsu, H., Hirata, Y., Takeuchi, T. et al. Fluvastatin ameriolates the erectile dysfunction in obese Zucker rats. J Urol 2003, 169 (4 Suppl.): Abst. 1221.
13. Zhu, J.H., Tao, Q.M., Chen, J.Z., Wang, X.X., Zhu, J.H., Shang, Y.P. Statins contribute to enhancement of the number and the function of endothelial progenitor cells from peripheral blood. Sheng Li Xue Bao 2004, 56: 357-64.
14. Werner, N., Nickenig, G. Clinical and therapeutical implications of EPC biology in atherosclerosis. J Cell Mol Med 2006, 10: 318-32.
15. Baumhakel, M., Werner, N., Bohm, M., Nickenig, G. Circulating endothelial progenitor cells correlate with erectile function in patients with coronary heart disease. Eur Heart J 2006, 27: 2184-8.
16. Dimmeler, S., Aicher, A., Vasa, M. et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 2001, 108: 391-7.
17. Castro, M.M., Rizzi, E., Rascado, R.R., Nagassaki, S., Bendhack, L.M., Tanus-Santos, J.E. Atorvastatin enhances sildenafil-induced vasodilation through nitric oxide-mediated mechanisms. Eur J Pharmacol 2004, 498: 189-94.
18. Herrmann, H.C., Levine, L.A., Macaluso, J. Jr. et al. Can atorvastatin improve the response to sildenafil in men with erectile dysfunction not initially responsive to sildenafil? Hypothesis and pilot trial results. J Sex Med 2006, 3: 303-8.
19. Mercuro, G., Marazzi, G., Fini, M. et al. Effect of atorvastatin and sildenafil on endothelial function in patients with erectile dysfunction and increased cardiovascular risk. 53rd Ann Sci Sess Am Coll Cardiol (ACC), New Orleans 2004. Abst. 1141-96.
20. Saltzman, E.A., Guay, A.T., Jacobson, J. Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: A clinical observation. J Urol 2004, 172: 255-8.
21. Influence of treatment with the HMG-CoA-reductase inhibitor fluvastatin on erectile function in patients with cardiovascular risk-factors and erectile dysfunction. Clinical Trials Gov Identifier NCT00382161 2006.