-
1
-
-
1442310994
-
Management of colorectal cancer in elderly patients: Focus on the cost of chemotherapy
-
Matasar MJ, Sundararajan V, Grann VR, et al. Management of colorectal cancer in elderly patients: focus on the cost of chemotherapy. Drugs Aging 2004; 2 (2): 113-33
-
(2004)
Drugs Aging
, vol.2
, Issue.2
, pp. 113-133
-
-
Matasar, M.J.1
Sundararajan, V.2
Grann, V.R.3
-
2
-
-
0032413790
-
Relative survival in elderly cancer patients in Europe
-
Vercelli M, Quaglia A, Casella C, et al. Relative survival in elderly cancer patients in Europe. Eur J Cancer 1998; 34: 2264-70
-
(1998)
Eur J Cancer
, vol.34
, pp. 2264-2270
-
-
Vercelli, M.1
Quaglia, A.2
Casella, C.3
-
4
-
-
22144473678
-
Management of advanced colorectal cancer in older patients
-
Apr;
-
Lichtman SM. Management of advanced colorectal cancer in older patients. Oncology 2005 Apr; 19 (5): 597-602
-
(2005)
Oncology
, vol.19
, Issue.5
, pp. 597-602
-
-
Lichtman, S.M.1
-
5
-
-
1842681949
-
Introduction: Cancer in the elderly
-
Muss HB, Longo DL. Introduction: cancer in the elderly. Semin Oncol 2004; 31: 125-7
-
(2004)
Semin Oncol
, vol.31
, pp. 125-127
-
-
Muss, H.B.1
Longo, D.L.2
-
6
-
-
0035846320
-
A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients
-
Sargent DJ, Goldberg RM, Jacobson SD, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001; 345: 1091-7
-
(2001)
N Engl J Med
, vol.345
, pp. 1091-1097
-
-
Sargent, D.J.1
Goldberg, R.M.2
Jacobson, S.D.3
-
7
-
-
0345168137
-
Guidelines for the treatment of elderly cancer patients
-
Lichtmann SM. Guidelines for the treatment of elderly cancer patients. Cancer Control 2003; 10 (6): 445-53
-
(2003)
Cancer Control
, vol.10
, Issue.6
, pp. 445-453
-
-
Lichtmann, S.M.1
-
8
-
-
0029009209
-
Entry and evaluation of elderly patients in European Organization for Research and Treatment of Cancer (EORTC) new-drug-development studies
-
Monfardini S, Sorio R, Boes GH, et al. Entry and evaluation of elderly patients in European Organization for Research and Treatment of Cancer (EORTC) new-drug-development studies. Cancer 1995; 76: 333-8
-
(1995)
Cancer
, vol.76
, pp. 333-338
-
-
Monfardini, S.1
Sorio, R.2
Boes, G.H.3
-
9
-
-
0033619959
-
Underrepresentation of patients 65 years or older in cancer-treatment trials
-
Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years or older in cancer-treatment trials. N Engl J Med 1999; 341: 2061-7
-
(1999)
N Engl J Med
, vol.341
, pp. 2061-2067
-
-
Hutchins, L.F.1
Unger, J.M.2
Crowley, J.J.3
-
10
-
-
0000302556
-
Barriers to participation of older women with breast cancer in clinical trials [abstract]
-
Kemeny M, Muss HB, Kornblith AB, et al. Barriers to participation of older women with breast cancer in clinical trials [abstract]. Prog Proc Am Soc Clin Oncol 2000; 19: 602a
-
(2000)
Prog Proc Am Soc Clin Oncol
, vol.19
-
-
Kemeny, M.1
Muss, H.B.2
Kornblith, A.B.3
-
11
-
-
0028070572
-
Representation of older patients in cancer treatment trials
-
Trimble EL, Carter CL, Cain D, et al. Representation of older patients in cancer treatment trials. Cancer 1994; 74 Suppl. 7: 2208-14
-
(1994)
Cancer
, vol.74
, Issue.SUPPL. 7
, pp. 2208-2214
-
-
Trimble, E.L.1
Carter, C.L.2
Cain, D.3
-
12
-
-
0035846327
-
Older age: Not a barrier to cancer treatment
-
Muss HB. Older age: not a barrier to cancer treatment. N Engl J Med 2001; 345 (15): 1128-9
-
(2001)
N Engl J Med
, vol.345
, Issue.15
, pp. 1128-1129
-
-
Muss, H.B.1
-
13
-
-
0032104347
-
Comorbidity and age as predictors of risk for early mortality of male and female colon carcinoma patients: A population-based study
-
Yancik R, Wesley MN, Ries LA, et al. Comorbidity and age as predictors of risk for early mortality of male and female colon carcinoma patients: a population-based study. Cancer 1998; 82: 2123-34
-
(1998)
Cancer
, vol.82
, pp. 2123-2134
-
-
Yancik, R.1
Wesley, M.N.2
Ries, L.A.3
-
14
-
-
0031901577
-
Comorbidity and functional status are independent in older cancer patients
-
Extermann M, Overcash J, Lyman GH, et al. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 1998; 16 (4): 1582-7
-
(1998)
J Clin Oncol
, vol.16
, Issue.4
, pp. 1582-1587
-
-
Extermann, M.1
Overcash, J.2
Lyman, G.H.3
-
15
-
-
13744251436
-
Systemic therapy for colorectal cancer
-
Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med 2005; 352: 476-87
-
(2005)
N Engl J Med
, vol.352
, pp. 476-487
-
-
Meyerhardt, J.A.1
Mayer, R.J.2
-
16
-
-
0034675248
-
Surgery for colorectal cancer in elderly patients: A systematic review
-
Simmonds PD, Best L, George S, et al. Surgery for colorectal cancer in elderly patients: a systematic review. Lancet 2000; 356: 968-74
-
(2000)
Lancet
, vol.356
, pp. 968-974
-
-
Simmonds, P.D.1
Best, L.2
George, S.3
-
17
-
-
0034546847
-
Favorable short-term and long-term outcome after elective radical rectal cancer resection in patients 75 years of age or older
-
Puig-La Calle J Jr, Quayle J, Thaler HT, et al. Favorable short-term and long-term outcome after elective radical rectal cancer resection in patients 75 years of age or older. Dis Colon Rectum 2000; 43 (12): 1704-9
-
(2000)
Dis Colon Rectum
, vol.43
, Issue.12
, pp. 1704-1709
-
-
Puig-La Calle Jr, J.1
Quayle, J.2
Thaler, H.T.3
-
18
-
-
0642369247
-
What predicts serious complications in colorectal cancer resection?
-
Zingmond D, Maggard M, O'Connell J, et al. What predicts serious complications in colorectal cancer resection? Am Surg 2003; 69 (11): 969-74
-
(2003)
Am Surg
, vol.69
, Issue.11
, pp. 969-974
-
-
Zingmond, D.1
Maggard, M.2
O'Connell, J.3
-
19
-
-
4444325717
-
Use of surgery among elderly patients with stage IV colorectal cancer
-
Sep 1;
-
Temple LK, Hsieh L, Wong WD, et al. Use of surgery among elderly patients with stage IV colorectal cancer. J Clin Oncol 2004 Sep 1; 22 (17): 3475-84
-
(2004)
J Clin Oncol
, vol.22
, Issue.17
, pp. 3475-3484
-
-
Temple, L.K.1
Hsieh, L.2
Wong, W.D.3
-
20
-
-
33646110275
-
Chemotherapy for colorectal cancer
-
Goyle S, Maraveyas A. Chemotherapy for colorectal cancer. Dig Surg 2005; 22: 401-14
-
(2005)
Dig Surg
, vol.22
, pp. 401-414
-
-
Goyle, S.1
Maraveyas, A.2
-
21
-
-
4644252335
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysis
-
The Meta-Analysis Group in Cancer
-
The Meta-Analysis Group in Cancer. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis. J Clin Oncol 2004; 22: 3766-75
-
(2004)
J Clin Oncol
, vol.22
, pp. 3766-3775
-
-
-
22
-
-
34548144472
-
-
Best L, Simmonds P, Baughan C, et al. Palliative chemotherapy for advanced or metastatic colorectal cancer. In: Colorectal Meta-analysis Collaboration. The Cochrane Library. Issue 2. Chichester: John Wiley & Sons, Ltd, 2000: CD001545
-
Best L, Simmonds P, Baughan C, et al. Palliative chemotherapy for advanced or metastatic colorectal cancer. In: Colorectal Meta-analysis Collaboration. The Cochrane Library. Issue 2. Chichester: John Wiley & Sons, Ltd, 2000: CD001545
-
-
-
-
23
-
-
0034712536
-
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
-
Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000; 355: 1041-7
-
(2000)
Lancet
, vol.355
, pp. 1041-1047
-
-
Douillard, J.Y.1
Cunningham, D.2
Roth, A.D.3
-
24
-
-
0033874892
-
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
-
de Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18: 2938-47
-
(2000)
J Clin Oncol
, vol.18
, pp. 2938-2947
-
-
de Gramont, A.1
Figer, A.2
Seymour, M.3
-
25
-
-
2142703727
-
Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
-
Grothey A, Sargent D, Goldberg RM, et al. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004; 22: 1209-14
-
(2004)
J Clin Oncol
, vol.22
, pp. 1209-1214
-
-
Grothey, A.1
Sargent, D.2
Goldberg, R.M.3
-
26
-
-
28844482345
-
Adjuvant chemotherapy for stage III colon cancer: Implications of race/ethnicity, age and differentiation
-
Milburn Jessup J, Stewart A, Greene FL. Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age and differentiation. JAMA 2005; 294: 2703-11
-
(2005)
JAMA
, vol.294
, pp. 2703-2711
-
-
Milburn Jessup, J.1
Stewart, A.2
Greene, F.L.3
-
27
-
-
0032792959
-
Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
-
Popescu RA, Norman A, Ross PJ, et al. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 1999; 17 (8): 2412-8
-
(1999)
J Clin Oncol
, vol.17
, Issue.8
, pp. 2412-2418
-
-
Popescu, R.A.1
Norman, A.2
Ross, P.J.3
-
28
-
-
0036302615
-
Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: Results of a multivariate analysis of 3825 patients
-
Köhne CH, Cunningham D, di Costanzo F, et al. Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: results of a multivariate analysis of 3825 patients. Ann Oncol 2002; 13: 308-17
-
(2002)
Ann Oncol
, vol.13
, pp. 308-317
-
-
Köhne, C.H.1
Cunningham, D.2
di Costanzo, F.3
-
29
-
-
0033950054
-
Stage III colon cancer: Why adjuvant treatment is not offered to elderly patients
-
Mahoney T, Kuo Y-H, Topilow A, et al. Stage III colon cancer: why adjuvant treatment is not offered to elderly patients. Arch Surg 2000; 135: 182-5
-
(2000)
Arch Surg
, vol.135
, pp. 182-185
-
-
Mahoney, T.1
Kuo, Y.-H.2
Topilow, A.3
-
30
-
-
0035815928
-
Age and adjuvant chemotherapy use after surgery for stage III colon cancer
-
Schrag D, Cramer L, Bach P, et al. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst 2001; 93: 850-7
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 850-857
-
-
Schrag, D.1
Cramer, L.2
Bach, P.3
-
31
-
-
0001228284
-
Population based variation in the use of chemotherapy for colorectal cancer in the elderly [abstract]
-
Sundararajan V, Grann V, Neugut A. Population based variation in the use of chemotherapy for colorectal cancer in the elderly [abstract]. Proc Am Soc Clin Oncol 1999; 18: A1598
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
-
-
Sundararajan, V.1
Grann, V.2
Neugut, A.3
-
32
-
-
1842631407
-
Chemotherapy in the elderly
-
Lichtman SM. Chemotherapy in the elderly. Semin Oncol 2004; 31 (2): 160-74
-
(2004)
Semin Oncol
, vol.31
, Issue.2
, pp. 160-174
-
-
Lichtman, S.M.1
-
33
-
-
26444514977
-
Clinical pharmacology issues relevant to the dosing and toxicity of chemotherapy drugs in the elderly
-
Wasil T, Lichtman SM. Clinical pharmacology issues relevant to the dosing and toxicity of chemotherapy drugs in the elderly. Oncologist 2005; 10: 602-12
-
(2005)
Oncologist
, vol.10
, pp. 602-612
-
-
Wasil, T.1
Lichtman, S.M.2
-
34
-
-
0030973784
-
Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions
-
Sotaniemi EA, Arranto AJ, Pelkonen O, et al. Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions. Clin Pharmacol Ther 1997; 61: 331-9
-
(1997)
Clin Pharmacol Ther
, vol.61
, pp. 331-339
-
-
Sotaniemi, E.A.1
Arranto, A.J.2
Pelkonen, O.3
-
35
-
-
14844303761
-
Capecitabine: A review
-
Walko CM, Lindley C. Capecitabine: a review. Clin Ther 2005; 27 (1): 23-44
-
(2005)
Clin Ther
, vol.27
, Issue.1
, pp. 23-44
-
-
Walko, C.M.1
Lindley, C.2
-
36
-
-
0141993875
-
Administration of oxaliplatin to patients with renal dysfunction: A preliminary report of the National Cancer Institute Organ Dysfunction Working Group
-
Takimoto CH, Remick SC, Sharma S, et al. Administration of oxaliplatin to patients with renal dysfunction: a preliminary report of the National Cancer Institute Organ Dysfunction Working Group. Semin Oncol 2003; 30: 20-5
-
(2003)
Semin Oncol
, vol.30
, pp. 20-25
-
-
Takimoto, C.H.1
Remick, S.C.2
Sharma, S.3
-
37
-
-
17144430520
-
Recent advances in the systemic therapy of metastatic colorectal cancer
-
Jefford M, Zalcberg J. Recent advances in the systemic therapy of metastatic colorectal cancer. Am J Cancer 2005; 4 (1): 15-34
-
(2005)
Am J Cancer
, vol.4
, Issue.1
, pp. 15-34
-
-
Jefford, M.1
Zalcberg, J.2
-
38
-
-
1942453306
-
Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
-
van Kuilenburg AB. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 2004; 40 (7): 939-50
-
(2004)
Eur J Cancer
, vol.40
, Issue.7
, pp. 939-950
-
-
van Kuilenburg, A.B.1
-
39
-
-
26944470829
-
Expressions of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase in breast cancer and their correlations with prognosis
-
Li HX, Zh S, Zhang YH, et al. Expressions of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase in breast cancer and their correlations with prognosis. Chinese J Oncol 2004; 26 (11): 669-72
-
(2004)
Chinese J Oncol
, vol.26
, Issue.11
, pp. 669-672
-
-
Li, H.X.1
Zh, S.2
Zhang, Y.H.3
-
40
-
-
1642474408
-
The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas
-
Li H, Suo Z, Zhang Y, et al. The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas. Histol Histopathol 2004; 19 (1): 129-36
-
(2004)
Histol Histopathol
, vol.19
, Issue.1
, pp. 129-136
-
-
Li, H.1
Suo, Z.2
Zhang, Y.3
-
41
-
-
0344109583
-
Colorectal Cancer Meta-Analysis Project: Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
-
The Meta-Analysis Group in Cancer
-
The Meta-Analysis Group in Cancer. Colorectal Cancer Meta-Analysis Project: efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998; 16: 301-8
-
(1998)
J Clin Oncol
, vol.16
, pp. 301-308
-
-
-
42
-
-
0035871538
-
Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
-
Hoff PM, Ansari R, Batist G, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol 2001; 19 (8): 2282-92
-
(2001)
J Clin Oncol
, vol.19
, Issue.8
, pp. 2282-2292
-
-
Hoff, P.M.1
Ansari, R.2
Batist, G.3
-
43
-
-
0035503151
-
Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
-
Van Cutsem E, Twelves C, Cassidy J, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol 2001; 19 (21): 4097-106
-
(2001)
J Clin Oncol
, vol.19
, Issue.21
, pp. 4097-4106
-
-
Van Cutsem, E.1
Twelves, C.2
Cassidy, J.3
-
44
-
-
4644288273
-
Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: A pooled analysis of clinical trials
-
Folprecht G, Cunningham D, Ross P, et al. Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol 2004; 15: 1330-8
-
(2004)
Ann Oncol
, vol.15
, pp. 1330-1338
-
-
Folprecht, G.1
Cunningham, D.2
Ross, P.3
-
45
-
-
33744831506
-
Duration of adjuvant chemotherapy for colon cancer and survival among the elderly
-
Neugut AI, Matasar M, Wang X, et al. Duration of adjuvant chemotherapy for colon cancer and survival among the elderly. J Clin Oncol 2006; 24 (15): 2368-75
-
(2006)
J Clin Oncol
, vol.24
, Issue.15
, pp. 2368-2375
-
-
Neugut, A.I.1
Matasar, M.2
Wang, X.3
-
46
-
-
21144452813
-
Capecitabine as first line treatment for patients older than 70 years with metastatic colorectal cancer: An Oncopaz Cooperative Group Study
-
Feliu J, Escudero P, Llosa F, et al. Capecitabine as first line treatment for patients older than 70 years with metastatic colorectal cancer: an Oncopaz Cooperative Group Study. J Clin Oncol 2005; 23: 3104-11
-
(2005)
J Clin Oncol
, vol.23
, pp. 3104-3111
-
-
Feliu, J.1
Escudero, P.2
Llosa, F.3
-
47
-
-
0036235128
-
First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
-
Cassidy J, Twelves C, Van Cutsem E, et al. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol 2002; 13: 566-57
-
(2002)
Ann Oncol
, vol.13
, pp. 566-557
-
-
Cassidy, J.1
Twelves, C.2
Van Cutsem, E.3
-
48
-
-
31544439628
-
Treatment of colorectal cancer in the elderly: A review of the literature
-
Golfinopoulos V, Pentheroudakis G, Pavlidis N. Treatment of colorectal cancer in the elderly: a review of the literature. Cancer Treat Rev 2006; 32 (1): 1-8
-
(2006)
Cancer Treat Rev
, vol.32
, Issue.1
, pp. 1-8
-
-
Golfinopoulos, V.1
Pentheroudakis, G.2
Pavlidis, N.3
-
49
-
-
0032585197
-
Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
-
Rougier P, van Cutsem E, Bajetta E, et al. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 1998; 352: 1407-12
-
(1998)
Lancet
, vol.352
, pp. 1407-1412
-
-
Rougier, P.1
van Cutsem, E.2
Bajetta, E.3
-
50
-
-
0032585232
-
Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
-
Cunningham D, Pyrhonen S, James RD, et al. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 1998; 352: 1413-8
-
(1998)
Lancet
, vol.352
, pp. 1413-1418
-
-
Cunningham, D.1
Pyrhonen, S.2
James, R.D.3
-
51
-
-
24644432555
-
Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of cancer Gastrointestinal Group Study 40986
-
Köhne CH, Van Cutsem E, Wils JA, et al. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of cancer Gastrointestinal Group Study 40986. J Clin Oncol 2005; 23: 4856-65
-
(2005)
J Clin Oncol
, vol.23
, pp. 4856-4865
-
-
Köhne, C.H.1
Van Cutsem, E.2
Wils, J.A.3
-
52
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
-
Saltz LB, Cox JV, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 2000; 343: 905-14
-
(2000)
N Engl J Med
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
Cox, J.V.2
Blanke, C.3
-
53
-
-
0033558004
-
A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
-
Rothenberg M, Cox J, DeVore R, et al. A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma. Cancer 1999; 85: 786-95
-
(1999)
Cancer
, vol.85
, pp. 786-795
-
-
Rothenberg, M.1
Cox, J.2
DeVore, R.3
-
54
-
-
20644437768
-
Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors study
-
May 20;
-
Sastre J, Marcuello E, Masutti B, et al. Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors study. J Clin Oncol 2005 May 20; 23 (15): 3545-51
-
(2005)
J Clin Oncol
, vol.23
, Issue.15
, pp. 3545-3551
-
-
Sastre, J.1
Marcuello, E.2
Masutti, B.3
-
55
-
-
4143089333
-
Predictive factors of survival in patients with advanced colorectal cancer: An individual data analysis of 602 patients included in irinotecan phase III trials
-
Mitry E, Douillard JY, van Cutsem E, et al. Predictive factors of survival in patients with advanced colorectal cancer: an individual data analysis of 602 patients included in irinotecan phase III trials. Ann Oncol 2004; 15: 1013-7
-
(2004)
Ann Oncol
, vol.15
, pp. 1013-1017
-
-
Mitry, E.1
Douillard, J.Y.2
van Cutsem, E.3
-
56
-
-
7944223833
-
Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy
-
Chau I, Norman AR, Cunningham D, et al. Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Br J Cancer 2004; 91: 1453-8
-
(2004)
Br J Cancer
, vol.91
, pp. 1453-1458
-
-
Chau, I.1
Norman, A.R.2
Cunningham, D.3
-
57
-
-
6344231838
-
Pharmacogenetics of irinotecan toxicity
-
Oct;
-
Marsh S, McLeod HL. Pharmacogenetics of irinotecan toxicity. Pharmacogenomics 2004 Oct; 5 (7): 835-43
-
(2004)
Pharmacogenomics
, vol.5
, Issue.7
, pp. 835-843
-
-
Marsh, S.1
McLeod, H.L.2
-
58
-
-
33748529958
-
Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: A double-blind, randomized, placebo-controlled study
-
de Jong FA, Kehrer DFS, Mathijssen RHJ, et al. Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: a double-blind, randomized, placebo-controlled study. Oncologist 2006; 11 (8): 944-54
-
(2006)
Oncologist
, vol.11
, Issue.8
, pp. 944-954
-
-
de Jong, F.A.1
Kehrer, D.F.S.2
Mathijssen, R.H.J.3
-
59
-
-
0344783805
-
Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients
-
Becouarn Y, Ychou M, Ducreux M, et al. Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. J Clin Oncol 1998; 16: 2739-44
-
(1998)
J Clin Oncol
, vol.16
, pp. 2739-2744
-
-
Becouarn, Y.1
Ychou, M.2
Ducreux, M.3
-
60
-
-
0031741679
-
Oxaliplatin: A review of preclinical and clinical studies
-
Raymond E, Emanuel D, Rostagi R, et al. Oxaliplatin: a review of preclinical and clinical studies. Ann Oncol 1998; 9: 1053-71
-
(1998)
Ann Oncol
, vol.9
, pp. 1053-1071
-
-
Raymond, E.1
Emanuel, D.2
Rostagi, R.3
-
61
-
-
0033989203
-
Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
-
Giacchetti S, Perpoint B, Zidane R, et al. Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 2000; 18: 136-47
-
(2000)
J Clin Oncol
, vol.18
, pp. 136-147
-
-
Giacchetti, S.1
Perpoint, B.2
Zidane, R.3
-
62
-
-
33947390563
-
Oxaliplatin (with 5FU and leucovorin) in patients above age 70 (elderly) suffering from metastatic colorectal cancer: An observational study [abstract 8042]
-
Exquis B, Aapro M, Kohler S. Oxaliplatin (with 5FU and leucovorin) in patients above age 70 (elderly) suffering from metastatic colorectal cancer: an observational study [abstract 8042]. Proc Am Soc Clin Oncol 2004; 23: 735
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 735
-
-
Exquis, B.1
Aapro, M.2
Kohler, S.3
-
63
-
-
2942638081
-
XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
-
Cassidy J, Taberno J, Twelves C, et al. XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol 2004; 22: 2084-91
-
(2004)
J Clin Oncol
, vol.22
, pp. 2084-2091
-
-
Cassidy, J.1
Taberno, J.2
Twelves, C.3
-
64
-
-
33645731984
-
XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer
-
Feliu J, Salud A, Escudero P, et al. XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer. Br J Cancer 2006; 94 (7): 969-75
-
(2006)
Br J Cancer
, vol.94
, Issue.7
, pp. 969-975
-
-
Feliu, J.1
Salud, A.2
Escudero, P.3
-
65
-
-
22244477362
-
Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal cancer: Final results of the Southern Italy Cooperative Oncology Group (SICOG) trial 0108
-
Comella P, Natale D, Farris A, et al. Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal cancer: final results of the Southern Italy Cooperative Oncology Group (SICOG) trial 0108. Cancer 2005; 104: 282-9
-
(2005)
Cancer
, vol.104
, pp. 282-289
-
-
Comella, P.1
Natale, D.2
Farris, A.3
-
66
-
-
33947360413
-
-
Sargent DJ, Goldberg RM, Bleiberg H, et al. A pooled safety and efficacy analysis of the FOLFOX4 regimen (bi-monthly oxaliplatin plus fluorouracil/leucovorin) in elderly compared to younger patients with colorectal cancer [abstract no. 228]. In: Program and abstracts of the 2006 Gastrointestinal Cancers Symposium; 2006 Jan 26-28; San Francisco
-
Sargent DJ, Goldberg RM, Bleiberg H, et al. A pooled safety and efficacy analysis of the FOLFOX4 regimen (bi-monthly oxaliplatin plus fluorouracil/leucovorin) in elderly compared to younger patients with colorectal cancer [abstract no. 228]. In: Program and abstracts of the 2006 Gastrointestinal Cancers Symposium; 2006 Jan 26-28; San Francisco
-
-
-
-
67
-
-
0027415146
-
The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer
-
Mayer A, Takimoto M, Fritz E, et al. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993; 71: 2454-60
-
(1993)
Cancer
, vol.71
, pp. 2454-2460
-
-
Mayer, A.1
Takimoto, M.2
Fritz, E.3
-
68
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan refractory metastatic colorectal cancer
-
Jul 22;
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan refractory metastatic colorectal cancer. N Engl J Med 2004 Jul 22; 351 (4): 337-45
-
(2004)
N Engl J Med
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
69
-
-
0344773402
-
The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies [abstract]
-
Saltz L, Kies M, Abbruzzese JL, et al. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies [abstract]. Prog Proc Am Soc Clin Oncol 2003; 22: 204a
-
(2003)
Prog Proc Am Soc Clin Oncol
, vol.22
-
-
Saltz, L.1
Kies, M.2
Abbruzzese, J.L.3
-
70
-
-
12944332507
-
Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) to prolong progression-free survival in first-line colorectal cancer (CRC) in subjects who are not suitable candidates for first-line CPT-11 [abstract]
-
Kabbinavar FF, Schulz J, McCleod M, et al. Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) to prolong progression-free survival in first-line colorectal cancer (CRC) in subjects who are not suitable candidates for first-line CPT-11 [abstract]. Proc Am Soc Clin Oncol 2004; 23: 3516
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 3516
-
-
Kabbinavar, F.F.1
Schulz, J.2
McCleod, M.3
-
71
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350 (23): 2335-42
-
(2004)
N Engl J Med
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
72
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
Jan 1;
-
Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003 Jan 1; 21 (1): 60-5
-
(2003)
J Clin Oncol
, vol.21
, Issue.1
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
-
73
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Jul 31;
-
Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003 Jul 31; 349 (5): 427-34
-
(2003)
N Engl J Med
, vol.349
, Issue.5
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
74
-
-
33947398545
-
-
Maughan T. Fluorouracil, oxaliplatin, CPT-11, use and sequencing, in advanced colorectal cancer: the UK MRC FOCUS (CR08) Trial [abstract no. 165]. In: GI Cancers Symposium; 2005 Jan 27-29; Hollywood (FL)
-
Maughan T. Fluorouracil, oxaliplatin, CPT-11, use and sequencing, in advanced colorectal cancer: the UK MRC FOCUS (CR08) Trial [abstract no. 165]. In: GI Cancers Symposium; 2005 Jan 27-29; Hollywood (FL)
-
-
-
-
75
-
-
0035065094
-
-
Mattioli R, Lippe P, Recchia F, et al. Advanced colorectal cancer in elderly patients: tolerance and efficacy of leucovorin and fluorouracil bolus plus continuous infusion. Anticancer Res 2001 Jan-Feb; 21 (1A): 489-92
-
Mattioli R, Lippe P, Recchia F, et al. Advanced colorectal cancer in elderly patients: tolerance and efficacy of leucovorin and fluorouracil bolus plus continuous infusion. Anticancer Res 2001 Jan-Feb; 21 (1A): 489-92
-
-
-
-
76
-
-
1842681943
-
Gastrointestinal cancer in older patients
-
Enzinger PC, Mayer RJ. Gastrointestinal cancer in older patients. Semin Oncol 2004; 31 (2): 206-19
-
(2004)
Semin Oncol
, vol.31
, Issue.2
, pp. 206-219
-
-
Enzinger, P.C.1
Mayer, R.J.2
-
77
-
-
25444442283
-
High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer
-
Mattioli R, Massacesi C, Recchia F, et al. High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer. Ann Oncol 2005; 16 (7): 1147-51
-
(2005)
Ann Oncol
, vol.16
, Issue.7
, pp. 1147-1151
-
-
Mattioli, R.1
Massacesi, C.2
Recchia, F.3
-
78
-
-
0033008996
-
Toward an understanding of frailty
-
Hamermann D. Toward an understanding of frailty. Ann Intern Med 1999; 130: 945-50
-
(1999)
Ann Intern Med
, vol.130
, pp. 945-950
-
-
Hamermann, D.1
-
79
-
-
0037931312
-
Oral chemotherapy for the older patient with cancer
-
Carreca I, Balducci L. Oral chemotherapy for the older patient with cancer. Am J Cancer 2002; 1 (2): 101-8
-
(2002)
Am J Cancer
, vol.1
, Issue.2
, pp. 101-108
-
-
Carreca, I.1
Balducci, L.2
-
80
-
-
0023092594
-
A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
-
Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40 (5): 373-83
-
(1987)
J Chronic Dis
, vol.40
, Issue.5
, pp. 373-383
-
-
Charlson, M.E.1
Pompei, P.2
Ales, K.L.3
-
81
-
-
0031901577
-
Comorbidity and functional status are independent in older cancer patients
-
Apr;
-
Extermann M, Overcash J, Lyman GH, et al. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 1998 Apr; 16 (4): 1582-7
-
(1998)
J Clin Oncol
, vol.16
, Issue.4
, pp. 1582-1587
-
-
Extermann, M.1
Overcash, J.2
Lyman, G.H.3
-
82
-
-
0033843393
-
The application of the principles of geriatrics to the management of the older person with cancer
-
Balducci L, Beghe C. The application of the principles of geriatrics to the management of the older person with cancer. Crit Rev Oncol Hematol 2000; 35 (3): 147-54
-
(2000)
Crit Rev Oncol Hematol
, vol.35
, Issue.3
, pp. 147-154
-
-
Balducci, L.1
Beghe, C.2
|