메뉴 건너뛰기




Volumn 24, Issue 3, 2007, Pages 223-238

First-line treatment strategies for elderly patients with metastatic colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MONOCLONAL ANTIBODY; OXALIPLATIN; PLACEBO; RALTITREXED;

EID: 33947385820     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200724030-00004     Document Type: Review
Times cited : (13)

References (82)
  • 1
    • 1442310994 scopus 로고    scopus 로고
    • Management of colorectal cancer in elderly patients: Focus on the cost of chemotherapy
    • Matasar MJ, Sundararajan V, Grann VR, et al. Management of colorectal cancer in elderly patients: focus on the cost of chemotherapy. Drugs Aging 2004; 2 (2): 113-33
    • (2004) Drugs Aging , vol.2 , Issue.2 , pp. 113-133
    • Matasar, M.J.1    Sundararajan, V.2    Grann, V.R.3
  • 2
    • 0032413790 scopus 로고    scopus 로고
    • Relative survival in elderly cancer patients in Europe
    • Vercelli M, Quaglia A, Casella C, et al. Relative survival in elderly cancer patients in Europe. Eur J Cancer 1998; 34: 2264-70
    • (1998) Eur J Cancer , vol.34 , pp. 2264-2270
    • Vercelli, M.1    Quaglia, A.2    Casella, C.3
  • 4
    • 22144473678 scopus 로고    scopus 로고
    • Management of advanced colorectal cancer in older patients
    • Apr;
    • Lichtman SM. Management of advanced colorectal cancer in older patients. Oncology 2005 Apr; 19 (5): 597-602
    • (2005) Oncology , vol.19 , Issue.5 , pp. 597-602
    • Lichtman, S.M.1
  • 5
    • 1842681949 scopus 로고    scopus 로고
    • Introduction: Cancer in the elderly
    • Muss HB, Longo DL. Introduction: cancer in the elderly. Semin Oncol 2004; 31: 125-7
    • (2004) Semin Oncol , vol.31 , pp. 125-127
    • Muss, H.B.1    Longo, D.L.2
  • 6
    • 0035846320 scopus 로고    scopus 로고
    • A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients
    • Sargent DJ, Goldberg RM, Jacobson SD, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 2001; 345: 1091-7
    • (2001) N Engl J Med , vol.345 , pp. 1091-1097
    • Sargent, D.J.1    Goldberg, R.M.2    Jacobson, S.D.3
  • 7
    • 0345168137 scopus 로고    scopus 로고
    • Guidelines for the treatment of elderly cancer patients
    • Lichtmann SM. Guidelines for the treatment of elderly cancer patients. Cancer Control 2003; 10 (6): 445-53
    • (2003) Cancer Control , vol.10 , Issue.6 , pp. 445-453
    • Lichtmann, S.M.1
  • 8
    • 0029009209 scopus 로고
    • Entry and evaluation of elderly patients in European Organization for Research and Treatment of Cancer (EORTC) new-drug-development studies
    • Monfardini S, Sorio R, Boes GH, et al. Entry and evaluation of elderly patients in European Organization for Research and Treatment of Cancer (EORTC) new-drug-development studies. Cancer 1995; 76: 333-8
    • (1995) Cancer , vol.76 , pp. 333-338
    • Monfardini, S.1    Sorio, R.2    Boes, G.H.3
  • 9
    • 0033619959 scopus 로고    scopus 로고
    • Underrepresentation of patients 65 years or older in cancer-treatment trials
    • Hutchins LF, Unger JM, Crowley JJ, et al. Underrepresentation of patients 65 years or older in cancer-treatment trials. N Engl J Med 1999; 341: 2061-7
    • (1999) N Engl J Med , vol.341 , pp. 2061-2067
    • Hutchins, L.F.1    Unger, J.M.2    Crowley, J.J.3
  • 10
    • 0000302556 scopus 로고    scopus 로고
    • Barriers to participation of older women with breast cancer in clinical trials [abstract]
    • Kemeny M, Muss HB, Kornblith AB, et al. Barriers to participation of older women with breast cancer in clinical trials [abstract]. Prog Proc Am Soc Clin Oncol 2000; 19: 602a
    • (2000) Prog Proc Am Soc Clin Oncol , vol.19
    • Kemeny, M.1    Muss, H.B.2    Kornblith, A.B.3
  • 11
    • 0028070572 scopus 로고
    • Representation of older patients in cancer treatment trials
    • Trimble EL, Carter CL, Cain D, et al. Representation of older patients in cancer treatment trials. Cancer 1994; 74 Suppl. 7: 2208-14
    • (1994) Cancer , vol.74 , Issue.SUPPL. 7 , pp. 2208-2214
    • Trimble, E.L.1    Carter, C.L.2    Cain, D.3
  • 12
    • 0035846327 scopus 로고    scopus 로고
    • Older age: Not a barrier to cancer treatment
    • Muss HB. Older age: not a barrier to cancer treatment. N Engl J Med 2001; 345 (15): 1128-9
    • (2001) N Engl J Med , vol.345 , Issue.15 , pp. 1128-1129
    • Muss, H.B.1
  • 13
    • 0032104347 scopus 로고    scopus 로고
    • Comorbidity and age as predictors of risk for early mortality of male and female colon carcinoma patients: A population-based study
    • Yancik R, Wesley MN, Ries LA, et al. Comorbidity and age as predictors of risk for early mortality of male and female colon carcinoma patients: a population-based study. Cancer 1998; 82: 2123-34
    • (1998) Cancer , vol.82 , pp. 2123-2134
    • Yancik, R.1    Wesley, M.N.2    Ries, L.A.3
  • 14
    • 0031901577 scopus 로고    scopus 로고
    • Comorbidity and functional status are independent in older cancer patients
    • Extermann M, Overcash J, Lyman GH, et al. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 1998; 16 (4): 1582-7
    • (1998) J Clin Oncol , vol.16 , Issue.4 , pp. 1582-1587
    • Extermann, M.1    Overcash, J.2    Lyman, G.H.3
  • 15
    • 13744251436 scopus 로고    scopus 로고
    • Systemic therapy for colorectal cancer
    • Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med 2005; 352: 476-87
    • (2005) N Engl J Med , vol.352 , pp. 476-487
    • Meyerhardt, J.A.1    Mayer, R.J.2
  • 16
    • 0034675248 scopus 로고    scopus 로고
    • Surgery for colorectal cancer in elderly patients: A systematic review
    • Simmonds PD, Best L, George S, et al. Surgery for colorectal cancer in elderly patients: a systematic review. Lancet 2000; 356: 968-74
    • (2000) Lancet , vol.356 , pp. 968-974
    • Simmonds, P.D.1    Best, L.2    George, S.3
  • 17
    • 0034546847 scopus 로고    scopus 로고
    • Favorable short-term and long-term outcome after elective radical rectal cancer resection in patients 75 years of age or older
    • Puig-La Calle J Jr, Quayle J, Thaler HT, et al. Favorable short-term and long-term outcome after elective radical rectal cancer resection in patients 75 years of age or older. Dis Colon Rectum 2000; 43 (12): 1704-9
    • (2000) Dis Colon Rectum , vol.43 , Issue.12 , pp. 1704-1709
    • Puig-La Calle Jr, J.1    Quayle, J.2    Thaler, H.T.3
  • 18
    • 0642369247 scopus 로고    scopus 로고
    • What predicts serious complications in colorectal cancer resection?
    • Zingmond D, Maggard M, O'Connell J, et al. What predicts serious complications in colorectal cancer resection? Am Surg 2003; 69 (11): 969-74
    • (2003) Am Surg , vol.69 , Issue.11 , pp. 969-974
    • Zingmond, D.1    Maggard, M.2    O'Connell, J.3
  • 19
    • 4444325717 scopus 로고    scopus 로고
    • Use of surgery among elderly patients with stage IV colorectal cancer
    • Sep 1;
    • Temple LK, Hsieh L, Wong WD, et al. Use of surgery among elderly patients with stage IV colorectal cancer. J Clin Oncol 2004 Sep 1; 22 (17): 3475-84
    • (2004) J Clin Oncol , vol.22 , Issue.17 , pp. 3475-3484
    • Temple, L.K.1    Hsieh, L.2    Wong, W.D.3
  • 20
    • 33646110275 scopus 로고    scopus 로고
    • Chemotherapy for colorectal cancer
    • Goyle S, Maraveyas A. Chemotherapy for colorectal cancer. Dig Surg 2005; 22: 401-14
    • (2005) Dig Surg , vol.22 , pp. 401-414
    • Goyle, S.1    Maraveyas, A.2
  • 21
    • 4644252335 scopus 로고    scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: An updated meta-analysis
    • The Meta-Analysis Group in Cancer
    • The Meta-Analysis Group in Cancer. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis. J Clin Oncol 2004; 22: 3766-75
    • (2004) J Clin Oncol , vol.22 , pp. 3766-3775
  • 22
    • 34548144472 scopus 로고    scopus 로고
    • Best L, Simmonds P, Baughan C, et al. Palliative chemotherapy for advanced or metastatic colorectal cancer. In: Colorectal Meta-analysis Collaboration. The Cochrane Library. Issue 2. Chichester: John Wiley & Sons, Ltd, 2000: CD001545
    • Best L, Simmonds P, Baughan C, et al. Palliative chemotherapy for advanced or metastatic colorectal cancer. In: Colorectal Meta-analysis Collaboration. The Cochrane Library. Issue 2. Chichester: John Wiley & Sons, Ltd, 2000: CD001545
  • 23
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000; 355: 1041-7
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 24
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18: 2938-47
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 25
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A, Sargent D, Goldberg RM, et al. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 2004; 22: 1209-14
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3
  • 26
    • 28844482345 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for stage III colon cancer: Implications of race/ethnicity, age and differentiation
    • Milburn Jessup J, Stewart A, Greene FL. Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age and differentiation. JAMA 2005; 294: 2703-11
    • (2005) JAMA , vol.294 , pp. 2703-2711
    • Milburn Jessup, J.1    Stewart, A.2    Greene, F.L.3
  • 27
    • 0032792959 scopus 로고    scopus 로고
    • Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
    • Popescu RA, Norman A, Ross PJ, et al. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 1999; 17 (8): 2412-8
    • (1999) J Clin Oncol , vol.17 , Issue.8 , pp. 2412-2418
    • Popescu, R.A.1    Norman, A.2    Ross, P.J.3
  • 28
    • 0036302615 scopus 로고    scopus 로고
    • Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: Results of a multivariate analysis of 3825 patients
    • Köhne CH, Cunningham D, di Costanzo F, et al. Clinical determinants of survival in patients with 5-fluorouracil-based treatment for metastatic colorectal cancer: results of a multivariate analysis of 3825 patients. Ann Oncol 2002; 13: 308-17
    • (2002) Ann Oncol , vol.13 , pp. 308-317
    • Köhne, C.H.1    Cunningham, D.2    di Costanzo, F.3
  • 29
    • 0033950054 scopus 로고    scopus 로고
    • Stage III colon cancer: Why adjuvant treatment is not offered to elderly patients
    • Mahoney T, Kuo Y-H, Topilow A, et al. Stage III colon cancer: why adjuvant treatment is not offered to elderly patients. Arch Surg 2000; 135: 182-5
    • (2000) Arch Surg , vol.135 , pp. 182-185
    • Mahoney, T.1    Kuo, Y.-H.2    Topilow, A.3
  • 30
    • 0035815928 scopus 로고    scopus 로고
    • Age and adjuvant chemotherapy use after surgery for stage III colon cancer
    • Schrag D, Cramer L, Bach P, et al. Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst 2001; 93: 850-7
    • (2001) J Natl Cancer Inst , vol.93 , pp. 850-857
    • Schrag, D.1    Cramer, L.2    Bach, P.3
  • 31
    • 0001228284 scopus 로고    scopus 로고
    • Population based variation in the use of chemotherapy for colorectal cancer in the elderly [abstract]
    • Sundararajan V, Grann V, Neugut A. Population based variation in the use of chemotherapy for colorectal cancer in the elderly [abstract]. Proc Am Soc Clin Oncol 1999; 18: A1598
    • (1999) Proc Am Soc Clin Oncol , vol.18
    • Sundararajan, V.1    Grann, V.2    Neugut, A.3
  • 32
    • 1842631407 scopus 로고    scopus 로고
    • Chemotherapy in the elderly
    • Lichtman SM. Chemotherapy in the elderly. Semin Oncol 2004; 31 (2): 160-74
    • (2004) Semin Oncol , vol.31 , Issue.2 , pp. 160-174
    • Lichtman, S.M.1
  • 33
    • 26444514977 scopus 로고    scopus 로고
    • Clinical pharmacology issues relevant to the dosing and toxicity of chemotherapy drugs in the elderly
    • Wasil T, Lichtman SM. Clinical pharmacology issues relevant to the dosing and toxicity of chemotherapy drugs in the elderly. Oncologist 2005; 10: 602-12
    • (2005) Oncologist , vol.10 , pp. 602-612
    • Wasil, T.1    Lichtman, S.M.2
  • 34
    • 0030973784 scopus 로고    scopus 로고
    • Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions
    • Sotaniemi EA, Arranto AJ, Pelkonen O, et al. Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions. Clin Pharmacol Ther 1997; 61: 331-9
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 331-339
    • Sotaniemi, E.A.1    Arranto, A.J.2    Pelkonen, O.3
  • 35
    • 14844303761 scopus 로고    scopus 로고
    • Capecitabine: A review
    • Walko CM, Lindley C. Capecitabine: a review. Clin Ther 2005; 27 (1): 23-44
    • (2005) Clin Ther , vol.27 , Issue.1 , pp. 23-44
    • Walko, C.M.1    Lindley, C.2
  • 36
    • 0141993875 scopus 로고    scopus 로고
    • Administration of oxaliplatin to patients with renal dysfunction: A preliminary report of the National Cancer Institute Organ Dysfunction Working Group
    • Takimoto CH, Remick SC, Sharma S, et al. Administration of oxaliplatin to patients with renal dysfunction: a preliminary report of the National Cancer Institute Organ Dysfunction Working Group. Semin Oncol 2003; 30: 20-5
    • (2003) Semin Oncol , vol.30 , pp. 20-25
    • Takimoto, C.H.1    Remick, S.C.2    Sharma, S.3
  • 37
    • 17144430520 scopus 로고    scopus 로고
    • Recent advances in the systemic therapy of metastatic colorectal cancer
    • Jefford M, Zalcberg J. Recent advances in the systemic therapy of metastatic colorectal cancer. Am J Cancer 2005; 4 (1): 15-34
    • (2005) Am J Cancer , vol.4 , Issue.1 , pp. 15-34
    • Jefford, M.1    Zalcberg, J.2
  • 38
    • 1942453306 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil
    • van Kuilenburg AB. Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil. Eur J Cancer 2004; 40 (7): 939-50
    • (2004) Eur J Cancer , vol.40 , Issue.7 , pp. 939-950
    • van Kuilenburg, A.B.1
  • 39
    • 26944470829 scopus 로고    scopus 로고
    • Expressions of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase in breast cancer and their correlations with prognosis
    • Li HX, Zh S, Zhang YH, et al. Expressions of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase in breast cancer and their correlations with prognosis. Chinese J Oncol 2004; 26 (11): 669-72
    • (2004) Chinese J Oncol , vol.26 , Issue.11 , pp. 669-672
    • Li, H.X.1    Zh, S.2    Zhang, Y.H.3
  • 40
    • 1642474408 scopus 로고    scopus 로고
    • The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas
    • Li H, Suo Z, Zhang Y, et al. The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas. Histol Histopathol 2004; 19 (1): 129-36
    • (2004) Histol Histopathol , vol.19 , Issue.1 , pp. 129-136
    • Li, H.1    Suo, Z.2    Zhang, Y.3
  • 41
    • 0344109583 scopus 로고    scopus 로고
    • Colorectal Cancer Meta-Analysis Project: Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • The Meta-Analysis Group in Cancer
    • The Meta-Analysis Group in Cancer. Colorectal Cancer Meta-Analysis Project: efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998; 16: 301-8
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 42
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff PM, Ansari R, Batist G, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol 2001; 19 (8): 2282-92
    • (2001) J Clin Oncol , vol.19 , Issue.8 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 43
    • 0035503151 scopus 로고    scopus 로고
    • Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: Results of a large phase III study
    • Van Cutsem E, Twelves C, Cassidy J, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. J Clin Oncol 2001; 19 (21): 4097-106
    • (2001) J Clin Oncol , vol.19 , Issue.21 , pp. 4097-4106
    • Van Cutsem, E.1    Twelves, C.2    Cassidy, J.3
  • 44
    • 4644288273 scopus 로고    scopus 로고
    • Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: A pooled analysis of clinical trials
    • Folprecht G, Cunningham D, Ross P, et al. Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol 2004; 15: 1330-8
    • (2004) Ann Oncol , vol.15 , pp. 1330-1338
    • Folprecht, G.1    Cunningham, D.2    Ross, P.3
  • 45
    • 33744831506 scopus 로고    scopus 로고
    • Duration of adjuvant chemotherapy for colon cancer and survival among the elderly
    • Neugut AI, Matasar M, Wang X, et al. Duration of adjuvant chemotherapy for colon cancer and survival among the elderly. J Clin Oncol 2006; 24 (15): 2368-75
    • (2006) J Clin Oncol , vol.24 , Issue.15 , pp. 2368-2375
    • Neugut, A.I.1    Matasar, M.2    Wang, X.3
  • 46
    • 21144452813 scopus 로고    scopus 로고
    • Capecitabine as first line treatment for patients older than 70 years with metastatic colorectal cancer: An Oncopaz Cooperative Group Study
    • Feliu J, Escudero P, Llosa F, et al. Capecitabine as first line treatment for patients older than 70 years with metastatic colorectal cancer: an Oncopaz Cooperative Group Study. J Clin Oncol 2005; 23: 3104-11
    • (2005) J Clin Oncol , vol.23 , pp. 3104-3111
    • Feliu, J.1    Escudero, P.2    Llosa, F.3
  • 47
    • 0036235128 scopus 로고    scopus 로고
    • First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
    • Cassidy J, Twelves C, Van Cutsem E, et al. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol 2002; 13: 566-57
    • (2002) Ann Oncol , vol.13 , pp. 566-557
    • Cassidy, J.1    Twelves, C.2    Van Cutsem, E.3
  • 48
    • 31544439628 scopus 로고    scopus 로고
    • Treatment of colorectal cancer in the elderly: A review of the literature
    • Golfinopoulos V, Pentheroudakis G, Pavlidis N. Treatment of colorectal cancer in the elderly: a review of the literature. Cancer Treat Rev 2006; 32 (1): 1-8
    • (2006) Cancer Treat Rev , vol.32 , Issue.1 , pp. 1-8
    • Golfinopoulos, V.1    Pentheroudakis, G.2    Pavlidis, N.3
  • 49
    • 0032585197 scopus 로고    scopus 로고
    • Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer
    • Rougier P, van Cutsem E, Bajetta E, et al. Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer. Lancet 1998; 352: 1407-12
    • (1998) Lancet , vol.352 , pp. 1407-1412
    • Rougier, P.1    van Cutsem, E.2    Bajetta, E.3
  • 50
    • 0032585232 scopus 로고    scopus 로고
    • Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer
    • Cunningham D, Pyrhonen S, James RD, et al. Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer. Lancet 1998; 352: 1413-8
    • (1998) Lancet , vol.352 , pp. 1413-1418
    • Cunningham, D.1    Pyrhonen, S.2    James, R.D.3
  • 51
    • 24644432555 scopus 로고    scopus 로고
    • Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of cancer Gastrointestinal Group Study 40986
    • Köhne CH, Van Cutsem E, Wils JA, et al. Phase III study of weekly high-dose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of cancer Gastrointestinal Group Study 40986. J Clin Oncol 2005; 23: 4856-65
    • (2005) J Clin Oncol , vol.23 , pp. 4856-4865
    • Köhne, C.H.1    Van Cutsem, E.2    Wils, J.A.3
  • 52
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Saltz LB, Cox JV, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 2000; 343: 905-14
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 53
    • 0033558004 scopus 로고    scopus 로고
    • A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
    • Rothenberg M, Cox J, DeVore R, et al. A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma. Cancer 1999; 85: 786-95
    • (1999) Cancer , vol.85 , pp. 786-795
    • Rothenberg, M.1    Cox, J.2    DeVore, R.3
  • 54
    • 20644437768 scopus 로고    scopus 로고
    • Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors study
    • May 20;
    • Sastre J, Marcuello E, Masutti B, et al. Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors study. J Clin Oncol 2005 May 20; 23 (15): 3545-51
    • (2005) J Clin Oncol , vol.23 , Issue.15 , pp. 3545-3551
    • Sastre, J.1    Marcuello, E.2    Masutti, B.3
  • 55
    • 4143089333 scopus 로고    scopus 로고
    • Predictive factors of survival in patients with advanced colorectal cancer: An individual data analysis of 602 patients included in irinotecan phase III trials
    • Mitry E, Douillard JY, van Cutsem E, et al. Predictive factors of survival in patients with advanced colorectal cancer: an individual data analysis of 602 patients included in irinotecan phase III trials. Ann Oncol 2004; 15: 1013-7
    • (2004) Ann Oncol , vol.15 , pp. 1013-1017
    • Mitry, E.1    Douillard, J.Y.2    van Cutsem, E.3
  • 56
    • 7944223833 scopus 로고    scopus 로고
    • Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy
    • Chau I, Norman AR, Cunningham D, et al. Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Br J Cancer 2004; 91: 1453-8
    • (2004) Br J Cancer , vol.91 , pp. 1453-1458
    • Chau, I.1    Norman, A.R.2    Cunningham, D.3
  • 57
    • 6344231838 scopus 로고    scopus 로고
    • Pharmacogenetics of irinotecan toxicity
    • Oct;
    • Marsh S, McLeod HL. Pharmacogenetics of irinotecan toxicity. Pharmacogenomics 2004 Oct; 5 (7): 835-43
    • (2004) Pharmacogenomics , vol.5 , Issue.7 , pp. 835-843
    • Marsh, S.1    McLeod, H.L.2
  • 58
    • 33748529958 scopus 로고    scopus 로고
    • Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: A double-blind, randomized, placebo-controlled study
    • de Jong FA, Kehrer DFS, Mathijssen RHJ, et al. Prophylaxis of irinotecan-induced diarrhea with neomycin and potential role for UGT1A1*28 genotype screening: a double-blind, randomized, placebo-controlled study. Oncologist 2006; 11 (8): 944-54
    • (2006) Oncologist , vol.11 , Issue.8 , pp. 944-954
    • de Jong, F.A.1    Kehrer, D.F.S.2    Mathijssen, R.H.J.3
  • 59
    • 0344783805 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients
    • Becouarn Y, Ychou M, Ducreux M, et al. Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. J Clin Oncol 1998; 16: 2739-44
    • (1998) J Clin Oncol , vol.16 , pp. 2739-2744
    • Becouarn, Y.1    Ychou, M.2    Ducreux, M.3
  • 60
    • 0031741679 scopus 로고    scopus 로고
    • Oxaliplatin: A review of preclinical and clinical studies
    • Raymond E, Emanuel D, Rostagi R, et al. Oxaliplatin: a review of preclinical and clinical studies. Ann Oncol 1998; 9: 1053-71
    • (1998) Ann Oncol , vol.9 , pp. 1053-1071
    • Raymond, E.1    Emanuel, D.2    Rostagi, R.3
  • 61
    • 0033989203 scopus 로고    scopus 로고
    • Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer
    • Giacchetti S, Perpoint B, Zidane R, et al. Phase III multicenter randomized trial of oxaliplatin added to chronomodulated fluorouracil-leucovorin as first-line treatment of metastatic colorectal cancer. J Clin Oncol 2000; 18: 136-47
    • (2000) J Clin Oncol , vol.18 , pp. 136-147
    • Giacchetti, S.1    Perpoint, B.2    Zidane, R.3
  • 62
    • 33947390563 scopus 로고    scopus 로고
    • Oxaliplatin (with 5FU and leucovorin) in patients above age 70 (elderly) suffering from metastatic colorectal cancer: An observational study [abstract 8042]
    • Exquis B, Aapro M, Kohler S. Oxaliplatin (with 5FU and leucovorin) in patients above age 70 (elderly) suffering from metastatic colorectal cancer: an observational study [abstract 8042]. Proc Am Soc Clin Oncol 2004; 23: 735
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 735
    • Exquis, B.1    Aapro, M.2    Kohler, S.3
  • 63
    • 2942638081 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
    • Cassidy J, Taberno J, Twelves C, et al. XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol 2004; 22: 2084-91
    • (2004) J Clin Oncol , vol.22 , pp. 2084-2091
    • Cassidy, J.1    Taberno, J.2    Twelves, C.3
  • 64
    • 33645731984 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer
    • Feliu J, Salud A, Escudero P, et al. XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer. Br J Cancer 2006; 94 (7): 969-75
    • (2006) Br J Cancer , vol.94 , Issue.7 , pp. 969-975
    • Feliu, J.1    Salud, A.2    Escudero, P.3
  • 65
    • 22244477362 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal cancer: Final results of the Southern Italy Cooperative Oncology Group (SICOG) trial 0108
    • Comella P, Natale D, Farris A, et al. Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal cancer: final results of the Southern Italy Cooperative Oncology Group (SICOG) trial 0108. Cancer 2005; 104: 282-9
    • (2005) Cancer , vol.104 , pp. 282-289
    • Comella, P.1    Natale, D.2    Farris, A.3
  • 66
    • 33947360413 scopus 로고    scopus 로고
    • Sargent DJ, Goldberg RM, Bleiberg H, et al. A pooled safety and efficacy analysis of the FOLFOX4 regimen (bi-monthly oxaliplatin plus fluorouracil/leucovorin) in elderly compared to younger patients with colorectal cancer [abstract no. 228]. In: Program and abstracts of the 2006 Gastrointestinal Cancers Symposium; 2006 Jan 26-28; San Francisco
    • Sargent DJ, Goldberg RM, Bleiberg H, et al. A pooled safety and efficacy analysis of the FOLFOX4 regimen (bi-monthly oxaliplatin plus fluorouracil/leucovorin) in elderly compared to younger patients with colorectal cancer [abstract no. 228]. In: Program and abstracts of the 2006 Gastrointestinal Cancers Symposium; 2006 Jan 26-28; San Francisco
  • 67
    • 0027415146 scopus 로고
    • The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer
    • Mayer A, Takimoto M, Fritz E, et al. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993; 71: 2454-60
    • (1993) Cancer , vol.71 , pp. 2454-2460
    • Mayer, A.1    Takimoto, M.2    Fritz, E.3
  • 68
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan refractory metastatic colorectal cancer
    • Jul 22;
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan refractory metastatic colorectal cancer. N Engl J Med 2004 Jul 22; 351 (4): 337-45
    • (2004) N Engl J Med , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 69
    • 0344773402 scopus 로고    scopus 로고
    • The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies [abstract]
    • Saltz L, Kies M, Abbruzzese JL, et al. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies [abstract]. Prog Proc Am Soc Clin Oncol 2003; 22: 204a
    • (2003) Prog Proc Am Soc Clin Oncol , vol.22
    • Saltz, L.1    Kies, M.2    Abbruzzese, J.L.3
  • 70
    • 12944332507 scopus 로고    scopus 로고
    • Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) to prolong progression-free survival in first-line colorectal cancer (CRC) in subjects who are not suitable candidates for first-line CPT-11 [abstract]
    • Kabbinavar FF, Schulz J, McCleod M, et al. Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) to prolong progression-free survival in first-line colorectal cancer (CRC) in subjects who are not suitable candidates for first-line CPT-11 [abstract]. Proc Am Soc Clin Oncol 2004; 23: 3516
    • (2004) Proc Am Soc Clin Oncol , vol.23 , pp. 3516
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 71
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350 (23): 2335-42
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 72
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Jan 1;
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003 Jan 1; 21 (1): 60-5
    • (2003) J Clin Oncol , vol.21 , Issue.1 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 73
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Jul 31;
    • Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003 Jul 31; 349 (5): 427-34
    • (2003) N Engl J Med , vol.349 , Issue.5 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 74
    • 33947398545 scopus 로고    scopus 로고
    • Maughan T. Fluorouracil, oxaliplatin, CPT-11, use and sequencing, in advanced colorectal cancer: the UK MRC FOCUS (CR08) Trial [abstract no. 165]. In: GI Cancers Symposium; 2005 Jan 27-29; Hollywood (FL)
    • Maughan T. Fluorouracil, oxaliplatin, CPT-11, use and sequencing, in advanced colorectal cancer: the UK MRC FOCUS (CR08) Trial [abstract no. 165]. In: GI Cancers Symposium; 2005 Jan 27-29; Hollywood (FL)
  • 75
    • 0035065094 scopus 로고    scopus 로고
    • Mattioli R, Lippe P, Recchia F, et al. Advanced colorectal cancer in elderly patients: tolerance and efficacy of leucovorin and fluorouracil bolus plus continuous infusion. Anticancer Res 2001 Jan-Feb; 21 (1A): 489-92
    • Mattioli R, Lippe P, Recchia F, et al. Advanced colorectal cancer in elderly patients: tolerance and efficacy of leucovorin and fluorouracil bolus plus continuous infusion. Anticancer Res 2001 Jan-Feb; 21 (1A): 489-92
  • 76
    • 1842681943 scopus 로고    scopus 로고
    • Gastrointestinal cancer in older patients
    • Enzinger PC, Mayer RJ. Gastrointestinal cancer in older patients. Semin Oncol 2004; 31 (2): 206-19
    • (2004) Semin Oncol , vol.31 , Issue.2 , pp. 206-219
    • Enzinger, P.C.1    Mayer, R.J.2
  • 77
    • 25444442283 scopus 로고    scopus 로고
    • High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer
    • Mattioli R, Massacesi C, Recchia F, et al. High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer. Ann Oncol 2005; 16 (7): 1147-51
    • (2005) Ann Oncol , vol.16 , Issue.7 , pp. 1147-1151
    • Mattioli, R.1    Massacesi, C.2    Recchia, F.3
  • 78
    • 0033008996 scopus 로고    scopus 로고
    • Toward an understanding of frailty
    • Hamermann D. Toward an understanding of frailty. Ann Intern Med 1999; 130: 945-50
    • (1999) Ann Intern Med , vol.130 , pp. 945-950
    • Hamermann, D.1
  • 79
    • 0037931312 scopus 로고    scopus 로고
    • Oral chemotherapy for the older patient with cancer
    • Carreca I, Balducci L. Oral chemotherapy for the older patient with cancer. Am J Cancer 2002; 1 (2): 101-8
    • (2002) Am J Cancer , vol.1 , Issue.2 , pp. 101-108
    • Carreca, I.1    Balducci, L.2
  • 80
    • 0023092594 scopus 로고
    • A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation
    • Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40 (5): 373-83
    • (1987) J Chronic Dis , vol.40 , Issue.5 , pp. 373-383
    • Charlson, M.E.1    Pompei, P.2    Ales, K.L.3
  • 81
    • 0031901577 scopus 로고    scopus 로고
    • Comorbidity and functional status are independent in older cancer patients
    • Apr;
    • Extermann M, Overcash J, Lyman GH, et al. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol 1998 Apr; 16 (4): 1582-7
    • (1998) J Clin Oncol , vol.16 , Issue.4 , pp. 1582-1587
    • Extermann, M.1    Overcash, J.2    Lyman, G.H.3
  • 82
    • 0033843393 scopus 로고    scopus 로고
    • The application of the principles of geriatrics to the management of the older person with cancer
    • Balducci L, Beghe C. The application of the principles of geriatrics to the management of the older person with cancer. Crit Rev Oncol Hematol 2000; 35 (3): 147-54
    • (2000) Crit Rev Oncol Hematol , vol.35 , Issue.3 , pp. 147-154
    • Balducci, L.1    Beghe, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.