Positive regulation of tumor necrosis factor-α by ganglioside GM3 through Akt in mouse melanoma B16 cells

Biochemical and Biophysical Research Communications

Volumn 356, Issue 2, 2007, Pages 438-443

  Wang, Pu ^a   Wu, Peixing ^b   Zhang, Jinghai ^a   Sato, Toshinori ^b   Yamagata, Sadako ^a   Yamagata, Tatsuya ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Akt; Ganglioside GM3; LY294,002; PI3K; TNF ; Wortmannin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; COMPLEMENTARY DNA; DEXTRO THREO 1 PHENYL 2 DECANOYLAMINO 3 MORPHOLINO 1 PROPANOL; GANGLIOSIDE GALACTOSYLTRANSFERASE; GANGLIOSIDE GM3; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROPANOL; PROTEIN KINASE B; SIALYLTRANSFERASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; MELANOMA CELL; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CHROMONES; G(M3) GANGLIOSIDE; MELANOMA; MICE; MORPHOLINES; PHOSPHORYLATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33947381060     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.02.152     Document Type: Article

References (29)

1. Zeller C.B., and Marchase R.B. Gangliosides as modulators of cell function. Am. J. Physiol. 262 (1992) 1341-1355
2. Nojiri H., Takaku F., Terui Y., Miura Y., and Saito M. Ganglioside GM3: an acidic membrane component that increases during macrophage-like cell differentiation can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines HL-60 and U937. Proc. Natl. Acad. Sci. USA 83 (1986) 782-786
3. Bremer E.G., Schlessinger J., and Hakomori S. Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. J. Biol. Chem. 261 (1986) 2434-2440
4. Kojima N., Shiota M., Sadahira Y., Handa K., and Hakomori S. Cell adhesion in a dynamic flow system as compared to static system. J. Biol. Chem. 267 (1992) 17264-17270
5. Hirabayashi Y., Hamaoka A., Matsumoto M., Matsubara T., Tagawa M., Wakabayash S., and Taniguchi M. Syngeneic monoclonal antibody against melanoma antigen with interspecies cross-reactivity recognizes GM3, a prominent ganglioside of B16 melanoma. J. Biol. Chem. 260 (1985) 13328-13333
6. Ruan S., and Lloyd K.O. Glycosylation pathways in the biosynthesis of gangliosides in melanoma and neuroblastoma cells: relative glycosyltransferase levels determine ganglioside patterns. Cancer Res. 52 (1992) 5725-5731
7. Vedralova E., Borovansky J., and Hach P. Ganglioside profiles of experimental melanomas and of their melanosomal fractions. Melanoma Res. 5 (1995) 87-92
8. Iwabuchi K., Yamamura S., Prinetti A., Handa K., and Hakomori S. GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate-carbohydrate interaction in mouse melanoma B16 cells. J. Biol. Chem. 273 (1998) 9130-9138
9. Ziegler-Heitbrock H.W., Kafferlein E., Haas J.G., Meyer N., Strobel M., Weber C., and Flieger D. Gangliosides suppress tumor necrosis factor production in human monocytes. J. Immunol. 148 (1992) 1753-1758
10. Irani D.N., Lin K.I., and Griffin D.E. Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells. J. Immunol. 157 (1996) 4333-4340
11. Pyo H., Joe E., Jung S., Lee S.H., and Jou I. Gangliosides activate cultured rat brain microglia. J. Biol. Chem. 274 (1999) 34584-34589
12. Jou I., Lee J.H., Park S.Y., Yoon H.J., Joe E.-H., and Park E.J. Gangliosides trigger inflammatory responses via TLR4 in brain glia. Am. J. Pathol. 168 (2006) 1619-1630
13. Hazeki K., Kinoshita S., Matsumura T., Nigorikawa K., Kubo H., and Hazeki O. Opposite effects of wortmannin and 2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride on toll-like receptor-mediated nitric oxide production: negative regulation of nuclear factor-κB by phosphoinositide 3-kinase. Mol. Pharmacol. 69 (2006) 1717-1724
14. Pahan K., Liu X., Wood C., and Raymond J.R. Expression of a constitutively active form of phosphatidylinositol 3-kinase inhibits induction of nitric oxide synthase in human astrocytes. FEBS Lett. 472 (2000) 203-207
15. Arnold S.K., Gustavo P.R., Bruno S., and Joel M. LY303511 (2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J. Pharmacol. Exp Ther. 314 (2005) 1134-1143
16. Guo R.X., Wei L.H., Tu Z., Sun P.M., Wang J.L., Zhao D., Li X.P., and Tang J.M. 17b-Estradiol activates PI3K/Akt signaling pathway by estrogen receptor (ER)-dependent and ER-independent mechanisms in endometrial cancer cells. J. Steroid Biochem. Mol. Biol. 99 (2006) 9-18
17. Wang L., Takaku S., Wang P., Hu D., Hyuga S., Sato T., Yamagata S., and Yamagata T. Ganglioside GD1a regulation of caveolin-1 and stim 1 expression in mouse FBJ cells: augmented expression of caveolin-1 and stim1 in cells with increased GD1a content. Glycoconj. J. 23 (2006) 303-315
18. Mutoh T., Tokuda A., Inokuchi J., and Kuriyama M. Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells. J. Biol. Chem. 273 (1998) 26001-26007
19. Ding J., Vlahos C.J., Liu R., Brown R.F., and Badwey J.A. Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils. J. Biol. Chem. 270 (1995) 11684-11691
20. Yamashita T., Hashiramato A., Haluzik M., Mizukami H., Beck S., Norton A., Kono M., Tsuji S., Daniotti J.L., Werth N., Sandhoff R., Sandhoff K., and Proia R.L. Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc. Natl. Acad. Sci. USA 100 (2003) 3445-3449
21. Hyuga S., Yamagata S., Takatsu Y., Hyuga M., Nakanishi H., Furukawa K., and Yamagata T. Suppression of FBJ-LL cell adhesion to vitronectin by ganglioside GD1a and loss of metastatic capacity. Int. J. Cancer 83 (1999) 685-691
22. Higashi H., and Yamagata T. Mechanism for ganglioside-mediated modulation of a calmodulin-dependent enzyme: modulation of calmodulin-dependent cyclic nucleotide phosphodiesterase activity through binding of gangliosides to calmodulin and the enzyme. J. Biol. Chem. 267 (1992) 9839-9843
23. Peterson R.T., and Schreiber S.L. Kinase phosphorylation: keeping it all in the family. Curr. Biol. 9 (1999) 521-524
24. Woodgett J.R. Recent advances in the protein kinase B signaling pathway. Curr. Opin. Cell Biol. 17 (2005) 150-157
25. Biondi R.M. Phosphoinositide-dependent protein kinase 1, a sensor of protein conformation. Trends Biochem. Sci. 29 (2004) 136-142
26. Scheid M.P., Marignani P.A., and Woodgett J.R. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol. Cell. Biol. 22 (2002) 6247-6260
27. Toker A., and Newton A.C. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J. Biol. Chem. 275 (2000) 8271-8274
28. Skeen J.E., Bhaskar P.T., Chen C.C., Chen W.S., Peng X.D., Nogueira V., Hahn-Windgassen A., Kiyokawa H., and Hay N. Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell 10 (2006) 269-280
29. P. Wang, X. Yang, P. Wu, J. Zhang, T. Sato, S. Yamagata, T. Yamagata, GM3 signals regulating Tnf-alpha mediated by Rictor and Arhgdib in mouse melanoma B16 cells, Oncology (2007), submitted for publication.