Impaired mononuclear cell immune function in extreme obesity is corrected by weight loss

Rejuvenation Research

Volumn 10, Issue 1, 2007, Pages 41-46

  Fontana, Luigi ^a,b   Eagon, J Christopher ^a   Colonna, Marco ^a   Klein, Samuel ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IONOMYCIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHORBOL 13 ACETATE 12 MYRISTATE;

ARTICLE; BODY MASS; DISEASE ASSOCIATION; HUMAN; IMMUNE RESPONSE; INFECTION RISK; OBESITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PREVALENCE; PRIORITY JOURNAL; STOMACH BYPASS; WEIGHT REDUCTION;

FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; OBESITY, MORBID; WEIGHT LOSS;

EID: 33947366325     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2006.0504     Document Type: Article

References (35)

1. Canturk Z, Canturk NZ, Cetinarslan B, Utkan NZ, Tarkun I. Nosocomial infections and obesity in surgical patients. Obes Res 2003;11(6):769-775.
2. Choban PS, Heckler R, Burge JC, Flancbaum L. Increased incidence of nosocomial infections in obese surgical patients. Am Surg 1995;61(11):1001-1005.
3. Yaegashi M, Jean R, Zuriqat M, Noack S, Homel P. Outcome of morbid obesity in the intensive care unit. J Intensive Care Med 2005;20(3):147-154.
4. Armstrong M. Obesity as an intrinsic factor affecting wound healing. J Wound Care 1998;7(5):220-221.
5. Kaye KS, Sloane R, Sexton DJ, Schmader KA. Risk factors for surgical site infections in older people. J Am Geriatr Soc 2006;54:391-396.
6. de Oliveira AC, Ciosak SI, Ferraz EM, Grinbaum RS Surgical site infection in patients submitted to digestive surgery: risk prediction and the NNIS risk index. Am J Infect Control 2006;34:201-207.
7. Prasad US, Walker WS, Sang CT, Campanella C, Cameron EW. Influence of obesity on the early and long term results of surgery for coronary artery disease. Eur J Cardiothorac Surg 1991;5:67-72.
8. Schwann TA, Habib RH, Zacharias A, Parenteau GL, Riordan CJ, Durham SJ, Engoren M: Effects of body size on operative, intermediate, and long-term outcomes after coronary artery bypass operation. Ann Thorac Surg 2001;71:521-530.
9. Hanish SI, Petersen RP, Collins BH, Tuttle-Newhall J, Marroquin CE, Kuo PC, Butterly DW, Smith SR, Desai DM. Obesity predicts increased overall complications following pancreas transplantation. Transplant Proc 2005;37:3564-3566.
10. Namba RS, Paxton L, Fithian DC, Stone ML. Obesity and perioperative morbidity in total hip and total knee arthroplasty patients. J Arthroplasty 2005;20(7 Suppl 3):46-50.
11. Gottschlich MM, Mayes T, Khoury JC, Warden GD. Significance of obesity on nutritional, immunologic, hormonal, and clinical outcome parameters in burns. J Am Diet Assoc 1993;93(11):1261-1268.
12. Palmblad J, Hallberg D, Engstedt L. Polymorphonuclear (PMN) function after small intestinal shunt operation for morbid obesity. Br J Haematol 1980;44(1): 101-108.
13. Tanaka S, Inoue S, Isoda F, Waseda M, Ishihara M, Yamakawa T, Sugiyama A, Takamura Y, Okuda K. Impaired immunity in obesity: suppressed but reversible lymphocyte responsiveness. Int J Obes Relat Metab Disord 1993;17(11):631-636.
14. Nieman DC, Henson DA, Nehlsen-Cannarella SL, Ekkens M, Utter AC, Butterworth DE, Fagoaga OR. Influence of obesity on immune function. J Am Diet Assoc 1999;99(3):294-299.
15. Delves PJ, Roitt IM. The immune system. Second of two parts. N Engl J Med 2000;343(2):108-117.
16. Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, North R, Gerard C, Rollins BJ. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 1998;187(4):601-608.
17. Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA. Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 1993;259:1739-1742.
18. Muller WA. New mechanisms and pathways for monocyte recruitment. J Exp Med 2001;194(9):F47-51
19. Boehm U, Klamp T, Groot M, Howard JC. Cellular responses to interferon-gamma. Annu Rev Immunol 1997;15:749-795.
20. Charo IF, Peters W. Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization. Microcirculation 2003;10:259-264.
21. Nieman DC, Henson DA, Nehlsen-Cannarella SL, Ekkens M, Utter AC, Butterworth DE, Fagoaga OR. Influence of obesity on immune function. J Am Diet Assoc 1999;99:294-299.
22. Moriguchi S, Kato M, Sakai K, Yamamoto S, Shimizu E. Decreased mitogen response of splenic lymphocytes in obese Zucker rats is associated with the decreased expression of glucose transporter 1 (GLUT-1). Am J Clin Nutr 1998;67:1124-1129.
23. Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, Ahmad S. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 2001;86(7):3257-3265.
24. Fox CJ, Hammerman PS, Thompson CB. Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol 2005;5(11):844-852.
25. Ikejima S, Sasaki S, Sashinami H, Mori F, Ogawa Y, Nakamura T, Abe Y, Wakabayashi K, Suda T, Nakane A. Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice. Diabetes 2005;54(1):182-189.
26. Chandra RK. Cell-mediated immunity in genetically obese C57BL/6J ob/ob) mice. Am J Clin Nutr 1980;33(1):13-16.
27. Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 2002;110(8):1093-1103.
28. Meier CA, Bobbioni E, Gabay C, Assimacopoulos-Jeannet F, Golay A, Dayer JM. IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin? J Clin Endocrinol Metab 2002;87(3):1184-1188.
29. Musso T, Cappello P, Stornello S, Ravarino D, Caorsi C, Otero K, Novelli F, Badolato R, Giovarelli M. IL-10 enhances CCL2 release and chemotaxis induced by CCL16 in human monocytes. Int J Immunopathol Pharmacol 2005;18(2):339-349.
30. Traill KN, Huber LA, Wick G, Jurgens G. Lipoprotein interactions with T cells: an update. Immunol Today 1990;11(11):411-417.
31. Rajala MW, Scherer PE. Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 2003;144(9): 3765-3773.
32. Cousin B, Andre M, Casteilla L, Penicaud L. Altered macrophage-like functions of preadipocytes in inflammation and genetic obesity. J Cell Physiol 2001;186:380-386.
33. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112(12):1821-1830.
34. Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R, Giugliano D. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003;289(14):1799-1804.
35. Cancello R, Henegar C, Viguerie N, Taleb S, Poitou C, Rouault C, Coupaye M, Pelloux V, Hugol D, Bouillot JL, Bouloumie A, Barbatelli G, Cinti S, Svensson PA, Barsh GS, Zucker JD, Basdevant A, Langin D, Clement K. Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 2005;54:2277-2286.