Antineutrophil nuclear antibodies (ANNA) in primary biliary cirrhosis: Their prevalence and antigen specificity

Zeitschrift fur Gastroenterologie

Volumn 35, Issue 2, 1997, Pages 113-121

  Orth, T ^a   Gerken, G ^a   Meyer zum Buschenfelde K H ^a,b   Mayet, W J ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Department of Internal Medicine ^*  (Germany)

Author keywords

ANCA; ANNA; antigen; autoimmune hepatitis; primary biliary cirrhosis; primary sclerosing cholangitis; SP100

Indexed keywords

AUTOANTIBODY; NEUTROPHIL CYTOPLASMIC ANTIBODY;

ANTIGEN SPECIFICITY; ARTICLE; BLOOD DONOR; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; LIVER CIRRHOSIS; PRIMARY BILIARY CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODIES, ANTINUCLEAR; ANTIGENS, NUCLEAR; AUTOANTIGENS; AUTOIMMUNE DISEASES; CELL NUCLEUS; CHOLANGITIS, SCLEROSING; CYTOPLASM; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEPATITIS; HUMANS; LIVER CIRRHOSIS, BILIARY; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; NEUTROPHILS; NUCLEAR PROTEINS;

EID: 0031050748     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Von Muhlen CA, Tan EM. Autoantibodies in the diagnosis of systemic rheumatic diseases. Semin Arthritis Rheum 1995; 24: 323-58
2. Davies DJ, Moran JE, Niall JF, Ryan GB. Segemental necrotizing glomerulonephritis with antineutrophil antibody: Possible arbovirus aetiology? Br Med J 1982; 285: 606
3. Wiik A, Rasmussen N, Wieslander J. Methods to detect autoantibodies to neutrophilic granulocytes. In: Van Venrooij WJ, Maini RN (eds). Manual of biological markers of disease. Dordrecht: Kluwer 1995; A 9: 1-7
4. Niles JL, McCluskey RT, Ahmat MF, Arnoud MA. Wegener's Granulomatosis autoantigen is a novel serine proteinase. Blood 1989; 74: 1888-93
5. Lüdemann J, Utecht B, Gross WL. Anti-neutrophil cytoplasmic antibodies in Wegener's Granulomatosis recognize an elastinolytic enzyme. J Exp Med 1990; 171: 357-62
6. Falk RJ, Jenette JC. Anti-neutrophil cytoplasmic antibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988; 318: 1651-7
7. Duerr RH, Targan SR, Landers CJ et al. Neutrophil Cytoplasmic Antibodies: A link between primary sclerosing cholangitis and ulcerative colitis. Gastroenterology 1991; 100: 1385-91
8. Seibold F, Weber P, Klein R, Berg PA, Wiedmann KH. Clinical significance of autoantibodies against neutrophils in patients with inflammatory bowel disease and primary sclerosing cholangitis. Gut 1992; 33: 657-62
9. Claise C, Johanet C, Bouhnik Y et al. Antineutrophil cytoplasmic autoantibodies in autoimmune liver and inflammatory bowel disease. Liver 1996; 16: 28-34
10. Hardarson S, LaBrecque DR, Mitros FA, Neil GA, Goeken JA. Antineutrophil cytoplasmic antibody in inflammatory bowel and hepatobiliary diseases. Am J Clin Pathol 1993; 99: 277-81
11. Mulder AHL, Horst G, Haagsma EB et al. Prevalence and characterization of neutrophil cytoplasmic autoantibodies in autoimmune liver disease. Hepatology 1993; 17: 411-17
12. Warny M, Brenard R, Cornu C, Tomasi JP, Geubel AP. Anti-neutrophil antibodies in chronic hepatitis and the effect of α-interferon therapy. J Hepatol 1993; 17: 294-300
13. Targan SR, Landers C, Vidrich A, Czaja AJ. Hightiter antineutrophil cytoplasmic antibodies in type-1 autoimmune hepatitis. Gastroenterology 1995; 108: 1159-66
14. Snook JA, Chapman RW, Fleming K, Jewell DP. Anti-neutrophil nuclear antibody in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis. Clin Exp Immunol 1989; 76: 30-3
15. Lo SK, Fleming KA, Chapman RW. Prevalence of antineutrophil antibody in primary sclerosing cholangitis and ulcerative colitis using an alkaline phosphatase technique. GUT 1992; 33: 1370-75
16. Boberg KM, Lundin KEA, Schrumpf E. Etiology and pathogenesis in primary sclerosing cholangitis. Scand J Gastroenterol 1994; 29 Suppl 20: 47-58
17. Wiessner RH. Current concepts in primary sclerosing cholangitis. Mayo Clin Proc 1994; 69: 969-82
18. Bansi D, Chapman R, Fleming K. Anti-neutrophil cytoplasmic antibodies in chronic liver diseases: prevalence, titre, specificity and IgG subclass. J Hepatol 1996; 24: 581-6
19. Kaplan MM. Primary biliary cirrhosis. N Engl J Med 1996; 335: 1570-80
20. Johnson PJ, McFarlane IG. Meeting report. International Autoimmune Hepatitis Group. Hepatology 1993; 18: 998-1005
21. Manns M, Gerken G, Kyriatsoulis A et al. Two different subtypes of antimitochondrial antibodies are associated with primary biliary cirrhosis: identification and characterization by radioimmunoassay and immunoblotting. Hepatology 1987; 5: 893-9
22. Manns M, Meyer zum Büschenfelde KH, Slusarczyk J, Dienes HP. Detection of liver-kidney microsomal autoantibodies by radioimmunoassay and their relation to anti-mitochondrial antibodies in inflammatory liver diseases. Clin Exp Immunol 1984; 57: 600-7
23. Manns M, Gerken G, Kyriatsoulis A, Staritz M, Meyer zum Büschenfelde KH. Characterization of a new subgroup of autoimmune chronic active hepatitis by autoantibodies against a soluble liver antigen. Lancet 1987; i: 292-4
24. Wächter B, Kyritasoulis A, Lohse AW et al. Characterization of liver cytokeratin as a major target antigen of anti-SLA antibodies. J Hepatol 1990; 11: 232-9
25. Treichel U, McFarlane BM, Seki T et al. Demographics of anti-asialoglycoprotein receptor autoantibodies in autoimmune hepatitis. Gastroenterology 1994; 107: 799-804
26. Wiik A, Rasmussen N, Wieslander J. Methods to detect autoantibodies to neutrophilic granulocytes. In: Van Venrooij WJ, Maini RN (eds.) Manual of biological markers of disease. Dordrecht: Kluwer 1993; A9: 8-14
27. Duclos-Vallee JC, Hadengue A, Ganne-Carrie N et al. Primary biliary cirrhosis -Autoimmune hepatitis overlap syndrome. Dig Dis Sci 1995; 40: 1069-73
28. Szostecki C, Krippner H, Penner E, Bautz FA. Autoimmune sera recognize a 100 kDa nuclear protein antigen (SP100). Clin Exp Immunol 1987; 68: 108-16
29. Szostecki C, Guldner HH, Netter HJ, Will H. Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. J Immunol 1990; 145: 4338-47
30. Orth T, Gerken G, Kellner R, Meyer zum Büschenfelde KH, Mayet WJ. Actin is a target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis Type-1. J Hepatol (in press)