Clinical relevance of antiphospholipid antibodies in primary biliary cirrhosis

Annals of the New York Academy of Sciences

Volumn 1051, Issue , 2005, Pages 20-28

  Von Landenberg, Philipp ^a   Baumgartner, Michael ^b   Schoelmerich, Juergen ^b   Lackner, Karl J ^a   Klein, Reinhild ^c  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Antiphospholipid antibodies (APAs); Autoimmune hepatitis (AIH); Primary biliary cirrhosis (PBC)

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTINUCLEAR ANTIBODY; ASPARTATE AMINOTRANSFERASE; AUTOANTIGEN; BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; MITOCHONDRION ANTIBODY; PHOSPHATIDYLSERINE; PHOSPHOLIPID ANTIBODY;

ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; AUTOIMMUNE HEPATITIS; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE MARKER; DISEASE SEVERITY; HUMAN; HUMAN TISSUE; INTRAHEPATIC CHOLESTASIS; LIVER INJURY; MAJOR CLINICAL STUDY; PRIMARY BILIARY CIRRHOSIS;

ANAS;

EID: 25444450751     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1361.043     Document Type: Conference Paper

References (26)

1. GERSHWIN, M.E., I.R. MACKAY, A. STURGESS & R.L. COPPEL. 1987. Identification and specificity of a cDNA encoding the 70 kD mitochondrial antigen recognized in primary biliary cirrhosis. J. Immunol. 138: 3525-3531.
2. YEAMAN, S.J., D.J. DANNER, D.J. MUTIMER, et al. 1988. Primary biliary cirrhosis: identification of two major M2 mitochondrial autoantigens. Lancet 1: 1067-1070.
3. BERG, P.A. & R. KLEIN. 1988. Molecular determination of the primary biliary cirrhosis-specific M2 antigen. Hepatology 8: 200-202.
4. LOZANO, F., A. PARÉS, L. BORCHE, et al. 1988. Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis. Hepatology 8: 930-938.
5. SZOSTECKI, C., H. WILL, H.J. NETTER & H.H. GULDNER. 1984. Autoantibodies to the nuclear Sp 100 protein in primary biliary cirrhosis and chronic active hepatitis. Clin. Exp. Immunol. 55: 553-560.
6. KLEIN, R., S. GOLLER & L. BIANCHI. 2003. Nodular regenerative hyperplasia (NRH) of the liver - a manifestation of "organ-specific antiphospholipid syndrome"? Immunobiology 207:51-57.
7. HUGHES, G.R. 1985. The anticardiolipin syndrome. Clin. Exp. Rheumatol. 3: 285-286.
8. HARRIS, E.N., A.E. GHARAVI, M.L. BOEY, et al. 1983. Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 2: 1211-1214.
9. WILSON, W.A., A.E. GHARAVI, T. KOIKE, et al. 1999. International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: report of an international workshop. Arthritis Rheum. 42: 1309-1311.
10. CERVERA, R., J.C. PIETTE, J. FONT, et al. 2002. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1000 patients. Arthritis Rheum. 46: 1019-1027.
11. COLINA, F., F. PINEDO, J.A. SOLIS, et al. 1992. Nodular regenerative hyperplasia of the liver in early histological stages of primary biliary cirrhosis. Gastroenterology 102: 1319-1324.
12. BUFFET, C., M. SINICO, G. ADDA, et al. 1991. Nodular regenerative hyperplasia and primary biliary cirrhosis. Gastroenterol. Clin. Biol. 15: 856-858.
13. ABE, M., T. MASUMOTO, T. NINOMIYA, et al. 2000. Hyperplastic liver nodules associated with early-stage primary biliary cirrhosis mimicking hepatocellular carcinoma. Dig. Dis. Sci. 45: 1563-1567.
14. VON LANDENBERG, P., J. SCHOLMERICH, J. VON KEMPIS & K.J. LACKNER. 2003. The combination of different antiphospholipid antibody subgroups in the sera of patients with autoimmune diseases is a strong predictor for thrombosis: a retrospective study from a single center. Immunobiology 207: 65-71.
15. SHOENFELD, Y., I. KRAUSE, F. KVAPIL, et al. 2003. Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndrome. J. Clin. Immunol. 23: 377-383.
16. BERG, P.A. & R. KLEIN. 1986. Mitochondrial antigens and autoantibodies: from anti-M1 to anti-M9. Klin. Wochenschr. 64: 897-909.
17. BIRNER, R. & G. DAUM. 2003. Biogenesis and cellular dynamics of aminoglycerophospholipids. Int. Rev. Cytol. 225: 273-323.
18. KLEIN, R., H. POINTNER, W. ZILLY, et al. 1997. Antimitochondrial antibody profiles in primary biliary cirrhosis distinguish at early stages between a benign and a progressive course: a prospective study on 200 patients followed for 10 years. Liver 17: 119-128.
19. STECHEMESSER, E., R. KLEIN & P.A. BERG. 1993. Characterization and clinical relevance of antiliver pancreas antibodies (anti-LP) in autoimmune hepatitis. Hepatology 18: 1-8.
20. KLEIN, R., U.M. ZANGER, T. BERG, et al. 1999. Overlapping but distinct specificities of antiliver-kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes. Clin. Exp. Immunol. 118: 290-297.
21. FADOK, V.A. & P.M. HENSON. 2003. Apoptosis: giving phosphatidylserine recognition an assist - with a twist. Curr. Biol. 13: R655-657.
22. SCHULTZ, D.R. & W.J. HARRINGTON, JR. 2003. Apoptosis: programmed cell death at a molecular level. Semin. Arthritis Rheum. 32: 345-369.
23. KIM, S.J., D. GERSHOV, X. MA, et al. 2002. I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. J. Exp. Med. 196: 655-665.
24. PITTONI, V. & G. VALESINI. 2002. The clearance of apoptotic cells: implications for autoimmunity. Autoimmun. Rev. 1: 154-161.
25. MOUTHON, L., S. LACROIX-DESMAZES, A. NOBREGA, et al. 1996. The self-reactive antibody repertoire of normal human serum IgM is acquired in early childhood and remains conserved throughout life. Scand. J. Immunol. 44: 243-251.
26. COUTINHO, A., M.D. KAZATCHKINE & S. AVRAMEAS. 1995. Natural autoantibodies. Curr. Opin. Immunol. 7: 812-818.