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Battershill C, Long P, Jaspars M: Marine biodiscovery: New drugs from the ocean depths. Biologist (2005) 52(2):107-114. An excellent general introduction to the field of marine natural products and their applications as well as major issues facing the field of marine biodiscovery.
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Battershill C, Long P, Jaspars M: Marine biodiscovery: New drugs from the ocean depths. Biologist (2005) 52(2):107-114. An excellent general introduction to the field of marine natural products and their applications as well as major issues facing the field of marine biodiscovery.
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Newman DJ, Cragg GM: Marine natural products and related compounds in clinical and advanced preclinical trials. J Nat Prod (2004) 67(8):1216-1238. A review which details the status of small-molecule therapeutics of marine origin in clinical and preclinical trials.
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Newman DJ, Cragg GM: Marine natural products and related compounds in clinical and advanced preclinical trials. J Nat Prod (2004) 67(8):1216-1238. A review which details the status of small-molecule therapeutics of marine origin in clinical and preclinical trials.
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Visegrady B, Lorinczy D, Hild G, Somogyi B, Nyitrai M: A simple model for the cooperative stabilisation of actin filaments by phalloidin and jasplakinolide. FEBS Lett (2005) 579(1):6-10. An outstanding example of the use of a sponge natural product to investigate fundamental processes within the cell.
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Visegrady B, Lorinczy D, Hild G, Somogyi B, Nyitrai M: A simple model for the cooperative stabilisation of actin filaments by phalloidin and jasplakinolide. FEBS Lett (2005) 579(1):6-10. An outstanding example of the use of a sponge natural product to investigate fundamental processes within the cell.
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Conus venoms: A rich source of novel ion channel-targeted peptides
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Turk T, Sepčić K, Mancini I, Guella G: 3-Alkylpyridinium and 3-alkylpyridine compounds from marine sponges, their synthesis, biological activities and potential use. In: Studies in Natural Product Chemistry (Bioactive Natural Products) (2007): in press.
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Turk, T.1
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Irreversible and reversible pore formation by polymeric alkylpyridinium salts (poly-APS) from the sponge Reniera sarai
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McClelland D, Evans RM, Abidin I, Sharma S, Choudhry FZ, Jaspars M, Sepcic K, Scott RH: Irreversible and reversible pore formation by polymeric alkylpyridinium salts (poly-APS) from the sponge Reniera sarai. Br J Pharmacol (2003) 139(8):1399-1408.
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Tucker SJ, McClelland D, Jaspars M, Sepcic K, MacEwan DJ, Scott RH: The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells. Biochim Biophys Acta Biomembr (2003) 1614(2):171-181. The application of transient membrane pores to deliver cDNA into cells. This is the first example of the use of pores to deliver genetic material.
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Tucker SJ, McClelland D, Jaspars M, Sepcic K, MacEwan DJ, Scott RH: The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells. Biochim Biophys Acta Biomembr (2003) 1614(2):171-181. The application of transient membrane pores to deliver cDNA into cells. This is the first example of the use of pores to deliver genetic material.
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A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones
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Koss D, Hindley K, David K, Mancini I, Guella G, Sepčić K, Turk T, Rebolj K, Riedel G, Platt B, Scott R: A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones. BMC Pharmacology (2007) 7:1
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Llewellyn L: Saxitoxin, a toxic marine natural product that targets a multitude of receptors. Nat Prod Rep (2006) 23(2):200-222. A review on saxitoxin and its analogs and their many biological activities, as viewed from an ecological context. Their interaction with known and proposed receptors is discussed.
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The neurotoxic lipopeptide kalkitoxin interacts with voltage-sensitive sodium channels in cerebellar granule neurons
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A new toxin from the sea anemone Condylactis gigantea with effect on sodium channel inactivation
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Identification of a novel class of nicotinic receptor antagonists - dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum
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Loughnan M, Nicke A, Jones A, Schroeder CI, Nevin ST, Adams DJ, Alewood PF, Lewis RJ: Identification of a novel class of nicotinic receptor antagonists - dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. J Biol Chem (2006) 281(34):24745-24755.
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Rauck R, Wallace M, Leong M, MineHart M, Webster L, Charapata S, Abraham J, Buffington D, Ellis D, Kartzinel R: A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain. J Pain Symptom Manage (2006) 31(5):393-406. The results of the clinical trial of ziconotide that resulted in its approval for the treatment of chronic pain. This treatment is the first of its kind to be approved from a marine origin. Current investigations into conotoxins will undoubtedly lead to treatments for other types of pain.
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